Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A Shot of Cortisone Stops Traumatic Stress

04.10.2011
TAU discovers a quick injection can prevent PTSD in 60% who experience trauma

As soldiers return home from tours in Afghanistan and Iraq, America must cope with the toll that war takes on mental health. But the treatment of Post Traumatic Stress Disorder (PTSD) is becoming increasingly expensive, and promises to escalate as yet another generation of veterans tries to heal its psychological wounds.

New hope for preventing the development of PTSD has been uncovered by Prof. Joseph Zohar of Tel Aviv University's Sackler Faculty of Medicine and the Sheba Medical Center, in collaboration with Prof. Hagit Cohen from Ben-Gurion University — and the key is a single dose of a common medication.

When a person suffers trauma, the body naturally increases its secretion of cortisone. Taking this natural phenomenon into account, Prof. Zohar set out to discover what a single extra dose of cortisone could do, when administered up to six hours after test subjects experienced a traumatizing event. The results, which will be published in the journal European Neuropsychopharmacology in October 2011, indicate that the likelihood that the patient will later develop PTSD is reduced by 60 percent.

Opening the window of opportunity

In most psychiatric conditions, it is impossible to establish a precise point of time at which the disorder manifested, Prof. Zohar says. But PTSD is unique in that is has an easily established timeline, beginning from the moment a patient experiences trauma. This makes PTSD eligible for treatment in the "golden hours" — a medical term that defines the precious few hours in which treatment can be most beneficial following a trauma, heart attack, stroke, or medical event. Receiving treatment in this window of opportunity can be critical.

In their animal models, Prof. Zohar and his fellow researchers first began treating PTSD in the window of opportunity up to six hours after a traumatic event. Two groups of rats were exposed to the smell of a cat, and one group was treated with cortisone after the event.

Following promising results with the rats, the researchers initiated a double-blind study in an emergency room, in which trauma victims entering the hospital were randomly assigned to receive a placebo or the cortisone treatment. Follow-up exams took place two weeks, one month, and three months after the event. Those patients who had received a shot of cortisone were more than sixty percent less likely to develop PTSD, they discovered.

Mimicking Mother Nature

When searching for a treatment method for PTSD, Prof. Zohar took his cue from Mother Nature. Most people who survive a traumatic experience don't develop PTSD because the cortisone that our body naturally produces protects us from developing the condition. But the right dose of cortisone at the right time could prove a source of secondary prevention for PTSD, he posited, helping along a natural process.

His approach also may circumvent the harm caused by dosing traumatised patients with other pharmaceuticals. In the emergency room, traumatized patients are often given medications such as Valium or Xanax, aimed at calming them down. In fact, Prof. Zohar says, these pills interfere with our natural and potent recovery process, hindering the secretion of cortisone. "Looking at the long term effect, people who received these medications had a greater chance of developing PTSD than those who did not," he explains.

Prof. Zohar will expand this small pilot study with a $1.3 million dollar grant from the National Institute of Mental Health. He and his fellow researchers are teaming up with Prof. Rachel Yehuda of Mount Sinai Hospital in New York City, who will help them uncover the biochemical processes and underlying mechanisms of cortisone treatments for traumatized patients.

People who suffer from PTSD are haunted by their traumatic memories; for them, the past is always present, Prof. Zohar explains. Cortisone, given at the right dose at the right time, may alleviate the power of these traumatic memories by preventing their consolidation.

George Hunka | EurekAlert!
Further information:
http://www.aftau.org

More articles from Health and Medicine:

nachricht MRI contrast agent locates and distinguishes aggressive from slow-growing breast cancer
25.09.2017 | Case Western Reserve University

nachricht Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.

Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

An international team of physicists a coherent amplification effect in laser excited dielectrics

25.09.2017 | Physics and Astronomy

LaserTAB: More efficient and precise contacts thanks to human-robot collaboration

25.09.2017 | Trade Fair News

Highest-energy cosmic rays have extragalactic origin

25.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>