In addition, a similar problem, i.e., stimulation of the immune system, will be encountered in transplantation of allografts or xenografts. Some studies used artificial nerve conduits to repair nerve defects.
Among the artificial nerve conduits used, nanofibrous poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) conduits exhibit several advantages. One advantage of these nerve conduits is that they can be bent to an angle of up to 180¢ª and then restore to their original shape, which is necessary for adaptation inside a living system. Moreover, the PHBV conduits have a thin wall and a highly porous structure, which are important determinants for nutrient transport into the conduit. A further advantage is that they can be easily fabricated and rolled to any required length and diameter by heat processing.
Dr. Esmaeil Biazar and team from Islamic Azad University, Tonekabon, Iran used nanofibrous PHBV conduit and autologous sciatic nerve to bridge 30-mm-long rat sciatic nerve gaps. Within 4 months after surgery, rat sciatic nerve functional recovery was evaluated per month by behavioral analyses. Results showed that rat sciatic nerve functional recovery was similar after nanofibrous PHBV conduit and autologous nerve grafting. These findings, published in the Neural Regeneration Research (Vol. 8, No. 27, 2013), suggest that nanofibrous PHBV conduit is suitable in use for repair of long-segment sciatic nerve defects.
Article: " Efficacy of nanofibrous conduits in repair of long- segment sciatic nerve defects," by Esmaeil Biazar1, Saeed Heidari Keshel2, 3, Majid Pouya4 (1 Department of Biomaterial Engineering, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran; 2 Student Research Committee, Proteomics Research Center, Faculty of Paramedical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 3 Department of Tissue Engineering, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; 4 Faculty of Medical Sciences, Tonekabon Branch, Islamic Azad University, Tonekabon, Iran)
Biazar E, Heidari SK, Pouya M. Efficacy of nanofibrous conduits in repair of long-segment sciatic nerve defects. Neural Regen Res. 2013;8(27):2501-2509.
Meng Zhao | EurekAlert!
Tracking movement of immune cells identifies key first steps in inflammatory arthritis
23.01.2017 | Massachusetts General Hospital
Team discovers how bacteria exploit a chink in the body's armor
20.01.2017 | University of Illinois at Urbana-Champaign
For the first time ever, a cloud of ultra-cold atoms has been successfully created in space on board of a sounding rocket. The MAIUS mission demonstrates that quantum optical sensors can be operated even in harsh environments like space – a prerequi-site for finding answers to the most challenging questions of fundamental physics and an important innovation driver for everyday applications.
According to Albert Einstein's Equivalence Principle, all bodies are accelerated at the same rate by the Earth's gravity, regardless of their properties. This...
An important step towards a completely new experimental access to quantum physics has been made at University of Konstanz. The team of scientists headed by...
Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...
Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.
While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...
Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales
Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...
19.01.2017 | Event News
10.01.2017 | Event News
09.01.2017 | Event News
24.01.2017 | Earth Sciences
24.01.2017 | Life Sciences
24.01.2017 | Physics and Astronomy