Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A fading sense of smell may signal onset of Parkinson's disease

15.12.2008
Northwestern Memorial physicians participate in study to detect early indicators and identify those at increased risk

Many individuals with Parkinson's disease are able to recall losing their sense of smell well before the onset of more commonly recognized symptoms such as tremors, impaired dexterity, speech problems, memory loss and decreased cognitive ability.

To determine if a fading sense of smell may signal Parkinson's, researchers at Northwestern Memorial Hospital and Northwestern University's Feinberg School of Medicine are participating in a national study to examine the correlation and ascertain whether smell loss presents a tool for early detection of the disease and an opportunity to delay or ultimately prevent more troublesome symptoms.

Nearly one million people in the United States are affected by Parkinson's disease, which stems from premature aging of dopamine-producing cells in the brain, and the number is likely to grow as the population ages. By the time Parkinson's disease is detected, most individuals have already experienced a 60 to 70 percent loss of dopamine-producing cells in the brain.

"Very little is known about the early stages of this disease," says Tanya Simuni, MD, director of Northwestern's Parkinson's Disease and Movement Disorders Center and Associate Professor of Neurology at Northwestern University's Feinberg School of Medicine. "By utilizing smell testing in conjunction with other tests, we hope to develop a system that identifies the presence of Parkinson's before it develops into problematic symptoms."

Northwestern is one of 15 sites nationwide and the only center in Illinois to participate in the Parkinson's Associated Risk Study (PARS), the largest long-term study in the United States of relatives of individuals with Parkinson's disease. Evaluating 7,500 relatives for three to five years, the study draws from research demonstrating that first-degree family members such as mothers, fathers, siblings or children have a slight increase in their risk to develop the disease. As age has been recognized as the single proven risk factor for the onset of Parkinson's symptoms, the study will monitor relatives 50 years or older.

PARS study participants will be sent a scratch-and-sniff test accompanied by a brief questionnaire to be completed at home, with possible follow-up through continued questionnaires or evaluation by a local neurologist. Participants may also be contacted for more extensive testing.

"This study presents an enormous opportunity to not only better understand the initial stages of Parkinson's, but also help future generations," says Dr. Simuni. "In the future, early detection combined with neuroprotective therapy may pave the way for interventions that slow the progression or even prevent the onset of Parkinson's disease."

Allison Richard | EurekAlert!
Further information:
http://www.nmh.org
http://www.parkinsons.northwestern.edu

More articles from Health and Medicine:

nachricht How cancer metastasis happens: Researchers reveal a key mechanism
19.01.2018 | Weill Cornell Medicine

nachricht Researchers identify new way to unmask melanoma cells to the immune system
17.01.2018 | Duke University Medical Center

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Artificial agent designs quantum experiments

On the way to an intelligent laboratory, physicists from Innsbruck and Vienna present an artificial agent that autonomously designs quantum experiments. In initial experiments, the system has independently (re)discovered experimental techniques that are nowadays standard in modern quantum optical laboratories. This shows how machines could play a more creative role in research in the future.

We carry smartphones in our pockets, the streets are dotted with semi-autonomous cars, but in the research laboratory experiments are still being designed by...

Im Focus: Scientists decipher key principle behind reaction of metalloenzymes

So-called pre-distorted states accelerate photochemical reactions too

What enables electrons to be transferred swiftly, for example during photosynthesis? An interdisciplinary team of researchers has worked out the details of how...

Im Focus: The first precise measurement of a single molecule's effective charge

For the first time, scientists have precisely measured the effective electrical charge of a single molecule in solution. This fundamental insight of an SNSF Professor could also pave the way for future medical diagnostics.

Electrical charge is one of the key properties that allows molecules to interact. Life itself depends on this phenomenon: many biological processes involve...

Im Focus: Paradigm shift in Paris: Encouraging an holistic view of laser machining

At the JEC World Composite Show in Paris in March 2018, the Fraunhofer Institute for Laser Technology ILT will be focusing on the latest trends and innovations in laser machining of composites. Among other things, researchers at the booth shared with the Aachen Center for Integrative Lightweight Production (AZL) will demonstrate how lasers can be used for joining, structuring, cutting and drilling composite materials.

No other industry has attracted as much public attention to composite materials as the automotive industry, which along with the aerospace industry is a driver...

Im Focus: Room-temperature multiferroic thin films and their properties

Scientists at Tokyo Institute of Technology (Tokyo Tech) and Tohoku University have developed high-quality GFO epitaxial films and systematically investigated their ferroelectric and ferromagnetic properties. They also demonstrated the room-temperature magnetocapacitance effects of these GFO thin films.

Multiferroic materials show magnetically driven ferroelectricity. They are attracting increasing attention because of their fascinating properties such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

10th International Symposium: “Advanced Battery Power – Kraftwerk Batterie” Münster, 10-11 April 2018

08.01.2018 | Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

 
Latest News

Let the good tubes roll

19.01.2018 | Materials Sciences

How cancer metastasis happens: Researchers reveal a key mechanism

19.01.2018 | Health and Medicine

Meteoritic stardust unlocks timing of supernova dust formation

19.01.2018 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>