Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A disease of mistaken identity

24.06.2014

The symptoms of Cushing disease are unmistakable to those who suffer from it – excessive weight gain, acne, distinct colored stretch marks on the abdomen, thighs and armpits, and a lump, or fat deposit, on the back of the neck. Yet the disorder often goes misdiagnosed.

To help combat misdiagnosis, Saleh Aldasouqi, an associate professor in the College of Human Medicine at Michigan State University, is drawing more attention to the rare disease through a case study, which followed a young patient displaying classic, yet more pronounced signs of the condition.


Saleh Aldasouqi is an associate professor and senior endocrinologist in the College of Human Medicine at Michigan State University. Courtesy photo

Caused mostly by small benign tumors in the pituitary gland that increase levels of the hormone cortisol, the disease and the growths initially can go undetected. Many of the symptoms are shared with other health issues, so the disease itself can be mistaken for obesity or depression in its early stages.

Aldasouqi, who is also a senior endocrinologist at the university, presented the study with MSU postgraduate students and co-authors Tiffany Burns, Deepthi Rao and Mamata Ojha, at the Endocrine Society’s annual International Congress of Endocrinology in Chicago on June 21.

For Sydney Kandell, her symptoms brought her to the emergency room multiple times over the course of a year with no clear diagnosis coming until she turned 18 years old. Now a community college student with aspirations of attending MSU in pediatric endocrinology, Kandell’s condition has greatly improved after treatment.

“What was so different about Sydney’s case was the size of the tumor we found and the excessive weight she put on in such a short amount of time,” Aldasouqi said.

“She gained about 100 pounds just in her senior year of high school, and her tumor was so much larger and more aggressive. It wreaked havoc on her body.” The aggressive tumor, known as Crooke’s Cell Adenoma, made Kandell’s case extremely rare with less than five percent, or about 100 cases like hers, reported worldwide.

The pea-size pituitary gland is part of the endocrine system and is found at the base of the brain. It’s often considered the master gland, controlling other glands such as the thyroid and adrenal, as well as many of the body’s everyday hormonal functions including body temperature, testosterone and estrogen.

“When you have even the smallest of tumors in this gland, it can significantly disrupt the way the body functions,” Aldasouqi said. “Sydney’s condition was elevated due to the size of her tumor, and now it’s through her story that other clinicians and even patients can learn to pay more attention to the symptoms and achieve an early diagnosis.”

Sarina Gleason | Eurek Alert!
Further information:
http://msutoday.msu.edu/news/2014/a-disease-of-mistaken-identity/

Further reports about: Cell Endocrine Human MSU Medicine aggressive diagnosis temperature

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>