Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

A disease of mistaken identity

24.06.2014

The symptoms of Cushing disease are unmistakable to those who suffer from it – excessive weight gain, acne, distinct colored stretch marks on the abdomen, thighs and armpits, and a lump, or fat deposit, on the back of the neck. Yet the disorder often goes misdiagnosed.

To help combat misdiagnosis, Saleh Aldasouqi, an associate professor in the College of Human Medicine at Michigan State University, is drawing more attention to the rare disease through a case study, which followed a young patient displaying classic, yet more pronounced signs of the condition.


Saleh Aldasouqi is an associate professor and senior endocrinologist in the College of Human Medicine at Michigan State University. Courtesy photo

Caused mostly by small benign tumors in the pituitary gland that increase levels of the hormone cortisol, the disease and the growths initially can go undetected. Many of the symptoms are shared with other health issues, so the disease itself can be mistaken for obesity or depression in its early stages.

Aldasouqi, who is also a senior endocrinologist at the university, presented the study with MSU postgraduate students and co-authors Tiffany Burns, Deepthi Rao and Mamata Ojha, at the Endocrine Society’s annual International Congress of Endocrinology in Chicago on June 21.

For Sydney Kandell, her symptoms brought her to the emergency room multiple times over the course of a year with no clear diagnosis coming until she turned 18 years old. Now a community college student with aspirations of attending MSU in pediatric endocrinology, Kandell’s condition has greatly improved after treatment.

“What was so different about Sydney’s case was the size of the tumor we found and the excessive weight she put on in such a short amount of time,” Aldasouqi said.

“She gained about 100 pounds just in her senior year of high school, and her tumor was so much larger and more aggressive. It wreaked havoc on her body.” The aggressive tumor, known as Crooke’s Cell Adenoma, made Kandell’s case extremely rare with less than five percent, or about 100 cases like hers, reported worldwide.

The pea-size pituitary gland is part of the endocrine system and is found at the base of the brain. It’s often considered the master gland, controlling other glands such as the thyroid and adrenal, as well as many of the body’s everyday hormonal functions including body temperature, testosterone and estrogen.

“When you have even the smallest of tumors in this gland, it can significantly disrupt the way the body functions,” Aldasouqi said. “Sydney’s condition was elevated due to the size of her tumor, and now it’s through her story that other clinicians and even patients can learn to pay more attention to the symptoms and achieve an early diagnosis.”

Sarina Gleason | Eurek Alert!
Further information:
http://msutoday.msu.edu/news/2014/a-disease-of-mistaken-identity/

Further reports about: Cell Endocrine Human MSU Medicine aggressive diagnosis temperature

More articles from Health and Medicine:

nachricht Understanding the Body’s Response to Worms and Allergies
24.04.2015 | University of Manchester

nachricht Caring for blindness: A new protein in sight?
22.04.2015 | NSERM (Institut national de la santé et de la recherche médicale)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fast and Accurate 3-D Imaging Technique to Track Optically-Trapped Particles

KAIST researchers published an article on the development of a novel technique to precisely track the 3-D positions of optically-trapped particles having complicated geometry in high speed in the April 2015 issue of Optica.

Daejeon, Republic of Korea, April 23, 2015--Optical tweezers have been used as an invaluable tool for exerting micro-scale force on microscopic particles and...

Im Focus: NOAA, Tulane identify second possible specimen of 'pocket shark' ever found

Pocket sharks are among the world's rarest finds

A very small and rare species of shark is swimming its way through scientific literature. But don't worry, the chances of this inches-long vertebrate biting...

Im Focus: Drexel materials scientists putting a new spin on computing memory

Ever since computers have been small enough to be fixtures on desks and laps, their central processing has functioned something like an atomic Etch A Sketch, with electromagnetic fields pushing data bits into place to encode data.

Unfortunately, the same drawbacks and perils of the mechanical sketch board have been just as pervasive in computing: making a change often requires starting...

Im Focus: Exploding stars help to understand thunderclouds on Earth

How is lightning initiated in thunderclouds? This is difficult to answer - how do you measure electric fields inside large, dangerously charged clouds? It was discovered, more or less by coincidence, that cosmic rays provide suitable probes to measure electric fields within thunderclouds. This surprising finding is published in Physical Review Letters on April 24th. The measurements were performed with the LOFAR radio telescope located in the Netherlands.

How is lightning initiated in thunderclouds? This is difficult to answer - how do you measure electric fields inside large, dangerously charged clouds? It was...

Im Focus: On the trail of a trace gas

Max Planck researcher Buhalqem Mamtimin determines how much nitrogen oxide is released into the atmosphere from agriculturally used oases.

In order to make statements about current and future air pollution, scientists use models which simulate the Earth’s atmosphere. A lot of information such as...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

HHL Energy Conference on May 11/12, 2015: Students Discuss about Decentralized Energy

23.04.2015 | Event News

“Developing our cities, preserving our planet”: Nobel Laureates gather for the first time in Asia

23.04.2015 | Event News

HHL's Entrepreneurship Conference on FinTech

13.04.2015 | Event News

 
Latest News

New Insight Into How Brain Makes Memories

27.04.2015 | Life Sciences

Customers prefer to pay more in advance to ensure that they will receive refunds later on

27.04.2015 | Studies and Analyses

Northwestern scientists develop first liquid nanolaser

27.04.2015 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>