Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

2.3 million Dollar funding for HIV vaccine development: RUB researchers want to trick immune system

29.10.2012
A new approach to HIV vaccine development
RUB-medical researchers want to trick the immune system
2.3 million Dollar funding from the Bill & Melinda Gates Foundation

To support their research for a vaccine against the HI-Virus, Prof. Dr. Klaus Überla of the Faculty for Medicine at the Ruhr-Universität Bochum and his research team will receive $2.3 million in funding within the next three years from the Bill & Melinda Gates Foundation. The scientists are part of the Collaboration for AIDS Vaccine Discovery (CAVD), which seeks to speed up the development of an HIV-vaccine through a rigorous exchange of information, methods and reagents.

“The project rests upon our observation that certain immunological reactions seem to increase the risk of HIV-infection,” Prof. Überla said. “We want to avoid these kinds of harmful immune system responses while still creating protective antibodies.”

Earlier study: HIV-vaccine increases risk of infection
Prior attempts to develop vaccines against HIV have not been successful. The preparation that was used in the Merck Pharmacy’s so-called STEP study actually increases HIV susceptibility. “It is extraordinarily important to understand why the vaccine has this effect,” Überla said. “These findings could have an enormous impact on the development of future substances.” By building on the findings of the STEP study, the research team plans to develop a new vaccine that will undergo in vivo testing.

T helper cells: HIV-proliferation vs. antibody production
Earlier studies have shown that certain antibodies against the envelope proteins of HIV could protect from HIV infection. Important for such antibody production are the CD4 T helper cells. Different kinds of these T helper cells recognize different pathogens in the body and signal other cells to create the appropriate antibodies in response to the invasive microorganisms. However, reactive CD4 T helper cells are also where HIV multiples particularly quickly. Therefore, if the number of HIV-responsive CD4 T helper cells increases as a result of the vaccine, the effect is simultaneously helpful and hurtful.

Helping, not hurting
The aim of the research project “Induction of affinity-matured HIV Env antibodies in the absence of HIV-specific T helper cells” is to investigate a new immunization method. Scientists associated with the project want to produce HIV antibodies through the use of T helper cells whose purpose is the recognition of other pathogens, rather than those which recognize the presence of HIV. This would mean that the number of T helper cells which respond to HIV would not go up through vaccination, thereby making it more difficult for HIV to multiply. The effectiveness of this new immunization method will be determined in cooperation with Dr. Stahl-Henning of the German Primate Center in Göttingen.
Further information

Prof. Dr. Klaus Überla, Department for Molecular and Medical Virology, Faculty for Medicine, Ruhr-Universität, 44780 Bochum, Germany, Phone: +49/234/32-23189
virologie@ruhr-uni-bochum.de

Click for more
Collaboration for AIDS Vaccine Discovery
https://www.cavd.org/Pages/default.aspx

Editor: Dr. Julia Weiler

Dr. Josef König | idw
Further information:
http://www.ruhr-uni-bochum.de

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

NASA eyes Pineapple Express soaking California

24.02.2017 | Earth Sciences

New gene for atrazine resistance identified in waterhemp

24.02.2017 | Agricultural and Forestry Science

New Mechanisms of Gene Inactivation may prevent Aging and Cancer

24.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>