According to Boston University Professor of Biomedical Engineering Mark W. Grinstaff, the best fluid supplement now available offers temporary symptom relief but provides inadequate lubrication to prevent further degradation of the cartilage surfaces that cushion the joint.
To achieve both objectives, Grinstaff, Beth Israel Deaconess Medical Center/Harvard Medical School orthopedic surgeon Brian Snyder and a team of Boston University chemistry and engineering students, fellows and clinicians have advanced the first synthetic synovial fluid. They describe the unique polymer and its performance in Journal of the American Chemical Society.
The most common form of joint disease and a leading cause of disability in the elderly, osteoarthritis (OA) affects about 27 million Americans and 200 million people worldwide. Characterized by pain and swelling, the disease emerges in hand, hip, knee and other commonly used joints where degradation of cartilage and synovial fluid results in bone-on-bone abrasion. Treatments range from anti-inflammatory drugs to total joint replacement. While there's no cure for OA, one treatment—injection of a polymer to supplement synovial fluid in the joint—promises to relieve symptoms and slow the disease's progression by reducing wear on cartilage surfaces.
"From our studies, we know our biopolymer is a superior lubricant in the joint, much better than the leading synovial fluid supplement, and similar to healthy synovial fluid," said Grinstaff. "When we used this new polymer, the friction between the two cartilage surfaces was lower, resulting in less wear and surface-to-surface interaction. It's like oil for the joints."
Originally produced last year for another study, the new polymer mimics some of the properties of natural polysaccharides, large compounds that link repetitive sequences of sugar molecules in a chainlike pattern.
"You put it between your fingers, and it's slippery," Grinstaff observed. "Once we made it, we wondered if we could use it as a lubricant and where it would be useful. That's how we thought of using it as a potential treatment for OA."
Another advantage of the biopolymer is its large molecular weight or size, which prevents it from seeping out of the joint, enabling longer lasting cartilage protection. Unlike the leading synovial fluid supplement, which lasts one or two days, the new polymer remains in the joint for more than two weeks.
The research is supported by the Wallace H. Coulter Foundation and Flex Biomedical, a startup cofounded by Grinstaff and Snyder.
Michael Seele | EurekAlert!
A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital
Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Physics and Astronomy
24.04.2017 | Materials Sciences
24.04.2017 | Life Sciences