Using mid-field wireless powering, investigators can transfer power from outside the body to electronics in the gastrointestinal tract
Imagers, gastric pacemakers and other diagnostic and therapeutic tools could someday transform the way diseases of the gastrointestinal tract are measured and treated. But in order for these electronic devices to work, they need a power source.
Traditional power sources, such as batteries, can be incompatible with the mucosal lining of the gastrointestinal tract and have a limited lifespan within the body. A more promising possibility is to power electronic devices from outside the body.
In a new study published in Scientific Reports, investigators from Brigham and Women's Hospital, Massachusetts Institute of Technology and The Charles Stark Draper Laboratory report that an ingestible electronic capsule, complete with a capsule-sized antenna capable of receiving a radio signal wirelessly, can safely power a device in the gastrointestinal tract in preclinical models. The new work makes wireless medical electronics for treating the gastrointestinal tract one step closer to reality.
"Electronic devices that can be placed in the gastrointestinal tract for prolonged periods of time have the potential to transform how we evaluate and treat patients.
This work describes the first example of remote, wireless transfer of power to a system in the stomach in a large preclinical animal model -- a critical step toward bringing these devices into the clinic," said co-corresponding author Carlo "Gio" Traverso, MD, PhD, a gastroenterologist and biomedical engineer at BWH.
Other medical devices -- such as cochlear implants or neural probes - use a well-established technique known as near-field coupling to deliver power wirelessly. But ingestible devices must be small enough to be swallowed and, moreover, lie a significant distance from the surface of the body, making this technique unattainable for most gastrointestinal electronics. A new technique known as mid-field coupling provides an alternative way to deliver power to deeply implanted devices. Mid-field coupling operates at higher frequencies to deliver power two to three times more efficiently.
To test whether mid-field coupling could help deliver power from outside the body into the gastrointestinal tract, the research team designed antennas capable of operating efficiently in tissue. They then placed one antenna outside of the body and the other in the esophagus, stomach and colon of a swine model. They were able to transmit power levels of 37.5 uW, 123 uW and 173 uW, respectively, all of which are sufficient to wirelessly power a range of medical devices from outside of the body.
"We are very excited about this work which we feel can someday offer many new opportunities for oral drug delivery of different molecules," said co-corresponding author Robert Langer, Institute Professor from the Harvard-MIT Division of Health Sciences and Technology.
"In further work, we would like to expand on these measurements by characterizing the effects of animal size, antenna depth, orientation and more on transmission efficiency, and focus on propagating fields - or the way power travels - to make transmission even more efficient," said Traverso.
This work was made possible in part through funding from the National Institutes of Health and a Draper Fellowship. The authors declare no competing financial interests or other interests that might be perceived to influence the results and/or discussion reported in this article.
Haley Bridger | EurekAlert!
First transcatheter implant for diastolic heart failure successful
16.11.2017 | The Ohio State University Wexner Medical Center
Theranostic nanoparticles for tracking and monitoring disease state
13.11.2017 | SLAS (Society for Laboratory Automation and Screening)
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
21.11.2017 | Physics and Astronomy
21.11.2017 | Physics and Astronomy
21.11.2017 | Life Sciences