Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Virginia Tech biomedical engineer pursues development of 5-D imaging technology

29.01.2014
Currently, the medical community has limited ability in clinically assessing blockages called atherosclerotic plaques in the human body.

These dangerous blockages that can lead to heart attacks and strokes are not easily diagnosed due to "the lack of noninvasive imaging techniques to accurately model atherosclerotic plaques in vivo," said Guohua Cao (http://www.sbes.vt.edu/cao.php), assistant professor of biomedical engineering at Virginia Tech.

With the award of a National Science Foundation CAREER grant valued at $400,000, Cao is currently working on developing an unprecedented, 5-D micro-computer tomography scanner for the in vivo imaging of atherosclerotic plaques in transgenic mouse models.

"Our innovative approach is to combine three separately developed technologies into one synergistic imaging system," Cao explained.

Cao and other researchers in his field of study have made such improvements in multiple types of imaging technologies that great improvements in medical knowledge have been verified in long-term studies of human disease in mice and rats.

However, "of all the imaging tasks involved with small animals, cardiovascular imaging is among the most challenging because the physiological motions of small animals are about ten times faster than those of humans," Cao said.

Cao, who spent six years as a research assistant professor and a postdoctoral scholar and fellow at Brown University and at the University of North Carolina at Chapel Hill before joining the Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, previously led a multidisciplinary team from the fields of physics, biomedical engineering, applied sciences, and radiology on the development of a carbon nanotube dynamic micro-computed tomography (CT) scanner.

This scanner (http://www.nature.com/news/2009/090728/full/news.2009.744.html#B1) is currently considered one of the world's best in obtaining dynamic high spatial and temporal resolution CT images of small animals.

Cao has built two such state-of-art CT scanners for the biomedical researcher community. One is installed at the UNC Biomedical Research Imaging Center, and the other is at the Department of Radiology at the University of Iowa Carver College of Medicine.

With his new NSF CAREER award, he now hopes to develop a carbon-nanotube field emission X-ray source to reduce the blurring of pictures that comes from the heart motions and to achieve the required time-based high resolution. His proposal calls for the integration of this specific type of X-ray with an energy-sensitive photon counting X-ray detector to develop his novel system.

Cao's previous work on developing carbon nanotube X-ray technologies has been featured in the popular press, such as in Nature, The Economist, Technology Review, Discovery News, and German Public Radio.

Cao is working on this project with Ge Wang of Rensselaer Polytechnic Institute and formerly of Virginia Tech. Both Wang and Cao are developing new medical imaging technologies that hold promise for improved early disease screening, cancer staging, therapeutic assessment, and other aspects of personalized medicine.

Cao has established the X-Ray Systems Laboratory (http://www.sbes.vt.edu/cao/,) and acts as the director for the SBES Advanced Multi-scale CT (SAM-CT) Laboratory (http://www.imaging.sbes.vt.edu/research/sam-ct/). The X-ray Systems Lab has two custom-built CT imaging systems - a DynaTom CNT micro-CT scanner, and a bench-top Xplorer micro-CT. The SAM-CT Lab houses four commercial CT imaging systems.

Together, they provide image resolution from 500 micrometers down to 50 nanometers, and sample size from 100 micrometers up to 100 millimeters, enabling biomedical discovery on a range of objects from a single cell to an adult rat. They represent the state-of-the-art in X-ray imaging capability at the university setting around the world.

Cao received his bachelor's degree from the University of Science and Technology of China and his doctoral degree from Brown University.

The College of Engineering (http://www.eng.vt.edu/) at Virginia Tech is internationally recognized for its excellence in 14 engineering disciplines and computer science.

The college's 6,000 undergraduates benefit from an innovative curriculum that provides a "hands-on, minds-on" approach to engineering education, complementing classroom instruction with two unique design-and-build facilities and a strong Cooperative Education Program. With more than 50 research centers and numerous laboratories, the college offers its 2,000 graduate students opportunities in advanced fields of study such as biomedical engineering, state-of-the-art microelectronics, and nanotechnology. Virginia Tech, the most comprehensive university in Virginia, is dedicated to quality, innovation, and results to the commonwealth, the nation, and the world.

Related Links
• Scanning innovation can improve personalized medicine (http://www.vtnews.vt.edu/articles/2012/11/112712-engineering-scanninginnovation.html)
This story can be found on the Virginia Tech News website:
http://www.vtnews.vt.edu/articles/2014/01/012914-engineering-guohuacaonsf.html

Lynn A. Nystrom | VT News
Further information:
http://www.vt.edu

More articles from Medical Engineering:

nachricht Tiny mechanical wrist gives new dexterity to needlescopic surgery
24.07.2015 | Vanderbilt University

nachricht Printing implants with the laser
21.07.2015 | Laser Zentrum Hannover e.V.

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Glaciers melt faster than ever

Glacier decline in the first decade of the 21st century has reached a historical record, since the onset of direct observations. Glacier melt is a global phenomenon and will continue even without further climate change. This is shown in the latest study by the World Glacier Monitoring Service under the lead of the University of Zurich, Switzerland.

The World Glacier Monitoring Service, domiciled at the University of Zurich, has compiled worldwide data on glacier changes for more than 120 years. Together...

Im Focus: Quantum Matter Stuck in Unrest

Using ultracold atoms trapped in light crystals, scientists from the MPQ, LMU, and the Weizmann Institute observe a novel state of matter that never thermalizes.

What happens if one mixes cold and hot water? After some initial dynamics, one is left with lukewarm water—the system has thermalized to a new thermal...

Im Focus: On the crest of the wave: Electronics on a time scale shorter than a cycle of light

Physicists from Regensburg and Marburg, Germany have succeeded in taking a slow-motion movie of speeding electrons in a solid driven by a strong light wave. In the process, they have unraveled a novel quantum phenomenon, which will be reported in the forthcoming edition of Nature.

The advent of ever faster electronics featuring clock rates up to the multiple-gigahertz range has revolutionized our day-to-day life. Researchers and...

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

Im Focus: Unlocking the rice immune system

Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight

A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

 
Latest News

“Seeing” molecular interactions could give boost to organic electronics

03.08.2015 | Materials Sciences

Stroke: news about platelets

03.08.2015 | Life Sciences

Molecular Spies to Fight Cancer - Procedure for improving tumor diagnosis successfully tested

03.08.2015 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>