These dangerous blockages that can lead to heart attacks and strokes are not easily diagnosed due to "the lack of noninvasive imaging techniques to accurately model atherosclerotic plaques in vivo," said Guohua Cao (http://www.sbes.vt.edu/cao.php), assistant professor of biomedical engineering at Virginia Tech.
With the award of a National Science Foundation CAREER grant valued at $400,000, Cao is currently working on developing an unprecedented, 5-D micro-computer tomography scanner for the in vivo imaging of atherosclerotic plaques in transgenic mouse models.
"Our innovative approach is to combine three separately developed technologies into one synergistic imaging system," Cao explained.
Cao and other researchers in his field of study have made such improvements in multiple types of imaging technologies that great improvements in medical knowledge have been verified in long-term studies of human disease in mice and rats.However, "of all the imaging tasks involved with small animals, cardiovascular imaging is among the most challenging because the physiological motions of small animals are about ten times faster than those of humans," Cao said.
Cao, who spent six years as a research assistant professor and a postdoctoral scholar and fellow at Brown University and at the University of North Carolina at Chapel Hill before joining the Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, previously led a multidisciplinary team from the fields of physics, biomedical engineering, applied sciences, and radiology on the development of a carbon nanotube dynamic micro-computed tomography (CT) scanner.
This scanner (http://www.nature.com/news/2009/090728/full/news.2009.744.html#B1) is currently considered one of the world's best in obtaining dynamic high spatial and temporal resolution CT images of small animals.
Cao has built two such state-of-art CT scanners for the biomedical researcher community. One is installed at the UNC Biomedical Research Imaging Center, and the other is at the Department of Radiology at the University of Iowa Carver College of Medicine.With his new NSF CAREER award, he now hopes to develop a carbon-nanotube field emission X-ray source to reduce the blurring of pictures that comes from the heart motions and to achieve the required time-based high resolution. His proposal calls for the integration of this specific type of X-ray with an energy-sensitive photon counting X-ray detector to develop his novel system.
Cao's previous work on developing carbon nanotube X-ray technologies has been featured in the popular press, such as in Nature, The Economist, Technology Review, Discovery News, and German Public Radio.
Cao is working on this project with Ge Wang of Rensselaer Polytechnic Institute and formerly of Virginia Tech. Both Wang and Cao are developing new medical imaging technologies that hold promise for improved early disease screening, cancer staging, therapeutic assessment, and other aspects of personalized medicine.
Cao has established the X-Ray Systems Laboratory (http://www.sbes.vt.edu/cao/,) and acts as the director for the SBES Advanced Multi-scale CT (SAM-CT) Laboratory (http://www.imaging.sbes.vt.edu/research/sam-ct/). The X-ray Systems Lab has two custom-built CT imaging systems - a DynaTom CNT micro-CT scanner, and a bench-top Xplorer micro-CT. The SAM-CT Lab houses four commercial CT imaging systems.
Together, they provide image resolution from 500 micrometers down to 50 nanometers, and sample size from 100 micrometers up to 100 millimeters, enabling biomedical discovery on a range of objects from a single cell to an adult rat. They represent the state-of-the-art in X-ray imaging capability at the university setting around the world.Cao received his bachelor's degree from the University of Science and Technology of China and his doctoral degree from Brown University.
The College of Engineering (http://www.eng.vt.edu/) at Virginia Tech is internationally recognized for its excellence in 14 engineering disciplines and computer science.
The college's 6,000 undergraduates benefit from an innovative curriculum that provides a "hands-on, minds-on" approach to engineering education, complementing classroom instruction with two unique design-and-build facilities and a strong Cooperative Education Program. With more than 50 research centers and numerous laboratories, the college offers its 2,000 graduate students opportunities in advanced fields of study such as biomedical engineering, state-of-the-art microelectronics, and nanotechnology. Virginia Tech, the most comprehensive university in Virginia, is dedicated to quality, innovation, and results to the commonwealth, the nation, and the world.Related Links
Lynn A. Nystrom | VT News
A laser for your eyes
18.04.2016 | Lomonosov Moscow State University
New technology for examining cardiovascular blood vessels
14.04.2016 | Laser Zentrum Hannover e.V.
Using an ultra fast-scanning atomic force microscope, a team of researchers from the University of Basel has filmed “living” nuclear pore complexes at work for the first time. Nuclear pores are molecular machines that control the traffic entering or exiting the cell nucleus. In their article published in Nature Nanotechnology, the researchers explain how the passage of unwanted molecules is prevented by rapidly moving molecular “tentacles” inside the pore.
Using high-speed AFM, Roderick Lim, Argovia Professor at the Biozentrum and the Swiss Nanoscience Institute of the University of Basel, has not only directly...
If a person pushes a broken-down car alone, there is a certain effect. If another person helps, the result is the sum of their efforts. If two micro-particles are pushing another microparticle, however, the resulting effect may not necessarily be the sum their efforts. A recent study published in Nature Communications, measured this odd effect that scientists call “many body.”
In the microscopic world, where the modern miniaturized machines at the new frontiers of technology operate, as long as we are in the presence of two...
Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.
Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...
Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.
In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...
Honeycomb structures as the basic building block for industrial applications presented using holo pyramid
Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...
27.04.2016 | Event News
15.04.2016 | Event News
12.04.2016 | Event News
03.05.2016 | Physics and Astronomy
03.05.2016 | Life Sciences
03.05.2016 | Physics and Astronomy