Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease.
The new imaging tool reveals strikingly different networks of blood vessels surrounding different types of tumors in a mouse model. Left: breast cancer in the breast. Middle: metastatic breast cancer in the brain. Right: ectopic breast cancer in the skin.
Credit: Nature Medicine
Now, to aid in that fight, a team of researchers has developed a sophisticated new optical imaging tool that enables scientists to look deep within tumors and uncover their inner workings. In experiments that will be described at Frontiers in Optics (FiO), The Optical Society's (OSA) Annual Meeting, Dai Fukumura and his colleagues will present new optical imaging techniques to track the movement of molecules, cells, and fluids within tumors; examine abnormalities in the blood vessel network inside them; and observe how the tumors were affected by treatments.
These techniques, created by Fukumura and his long-term collaborators at Massachusetts General Hospital and Harvard Medical School, combine two different high-tech optical imaging methods that were custom-built for the research. One is called multiphoton laser-scanning microscopy (MPLSM), which is an advanced fluorescence imaging technology that is now commercially available at the high end of the microscope market. The other is called optical frequency domain imaging (OFDI), which images tissues by their light scattering properties. According to Fukumura, OFDI is gaining popularity in the optical imaging field but has yet to become commercially available.
He added that while the new combined approach would be too expensive to be used for routine diagnostic purposes, it promises to help researchers better understand the intricate workings of human cancer and aid in drug discovery to treat cancer. "These optical imaging approaches can provide unprecedented insights in the biology and mechanisms of cancer," he said.
Presentation FW5A.2, "Experimental Methods for In Vivo Tissue Imaging," takes place Wednesday, Oct. 9 at 4:15 p.m. EDT at the Bonnet Creek Ballroom, Salon IV at the Hilton Bonnet Creek in Orlando, Fla.
Lyndsay Meyer | EurekAlert!
A laser for your eyes
18.04.2016 | Lomonosov Moscow State University
New technology for examining cardiovascular blood vessels
14.04.2016 | Laser Zentrum Hannover e.V.
Using an ultra fast-scanning atomic force microscope, a team of researchers from the University of Basel has filmed “living” nuclear pore complexes at work for the first time. Nuclear pores are molecular machines that control the traffic entering or exiting the cell nucleus. In their article published in Nature Nanotechnology, the researchers explain how the passage of unwanted molecules is prevented by rapidly moving molecular “tentacles” inside the pore.
Using high-speed AFM, Roderick Lim, Argovia Professor at the Biozentrum and the Swiss Nanoscience Institute of the University of Basel, has not only directly...
If a person pushes a broken-down car alone, there is a certain effect. If another person helps, the result is the sum of their efforts. If two micro-particles are pushing another microparticle, however, the resulting effect may not necessarily be the sum their efforts. A recent study published in Nature Communications, measured this odd effect that scientists call “many body.”
In the microscopic world, where the modern miniaturized machines at the new frontiers of technology operate, as long as we are in the presence of two...
Researchers from the Max Planck Institute Stuttgart have developed self-propelled tiny ‘microbots’ that can remove lead or organic pollution from contaminated water.
Working with colleagues in Barcelona and Singapore, Samuel Sánchez’s group used graphene oxide to make their microscale motors, which are able to adsorb lead...
Neutron scattering and computational modeling have revealed unique and unexpected behavior of water molecules under extreme confinement that is unmatched by any known gas, liquid or solid states.
In a paper published in Physical Review Letters, researchers at the Department of Energy's Oak Ridge National Laboratory describe a new tunneling state of...
Honeycomb structures as the basic building block for industrial applications presented using holo pyramid
Researchers of the Alfred Wegener Institute (AWI) will introduce their latest developments in the field of bionic lightweight design at Hannover Messe from 25...
27.04.2016 | Event News
15.04.2016 | Event News
12.04.2016 | Event News
06.05.2016 | Earth Sciences
06.05.2016 | Life Sciences
06.05.2016 | Life Sciences