Scientists seeking new ways to fight cancer often try to understand the subtle, often invisible, changes to DNA, proteins, cells, and tissue that alter the body's normal biology and cause disease.
The new imaging tool reveals strikingly different networks of blood vessels surrounding different types of tumors in a mouse model. Left: breast cancer in the breast. Middle: metastatic breast cancer in the brain. Right: ectopic breast cancer in the skin.
Credit: Nature Medicine
Now, to aid in that fight, a team of researchers has developed a sophisticated new optical imaging tool that enables scientists to look deep within tumors and uncover their inner workings. In experiments that will be described at Frontiers in Optics (FiO), The Optical Society's (OSA) Annual Meeting, Dai Fukumura and his colleagues will present new optical imaging techniques to track the movement of molecules, cells, and fluids within tumors; examine abnormalities in the blood vessel network inside them; and observe how the tumors were affected by treatments.
These techniques, created by Fukumura and his long-term collaborators at Massachusetts General Hospital and Harvard Medical School, combine two different high-tech optical imaging methods that were custom-built for the research. One is called multiphoton laser-scanning microscopy (MPLSM), which is an advanced fluorescence imaging technology that is now commercially available at the high end of the microscope market. The other is called optical frequency domain imaging (OFDI), which images tissues by their light scattering properties. According to Fukumura, OFDI is gaining popularity in the optical imaging field but has yet to become commercially available.
He added that while the new combined approach would be too expensive to be used for routine diagnostic purposes, it promises to help researchers better understand the intricate workings of human cancer and aid in drug discovery to treat cancer. "These optical imaging approaches can provide unprecedented insights in the biology and mechanisms of cancer," he said.
Presentation FW5A.2, "Experimental Methods for In Vivo Tissue Imaging," takes place Wednesday, Oct. 9 at 4:15 p.m. EDT at the Bonnet Creek Ballroom, Salon IV at the Hilton Bonnet Creek in Orlando, Fla.
Lyndsay Meyer | EurekAlert!
Vanderbilt Team First to Blend High-End Imaging Techniques
17.03.2015 | Vanderbilt University Medical Center
Developing radically new technologies for X-ray systems
04.02.2015 | Siemens AG
Spring is here and ectotherms, or animals dependent on external sources to raise their body temperature, are becoming more active. Recent studies have shown...
Glass-fronted office buildings are some of the biggest energy consumers, and regulating their temperature is a big job. Now a façade element developed by Fraunhofer researchers and designers for glass fronts is to reduce energy consumption by harnessing solar thermal energy. A demonstrator version will be on display at Hannover Messe.
In Germany, buildings account for almost 40 percent of all energy usage. Heating, cooling and ventilating homes, offices and public spaces is expensive – and...
Outstanding chemical, thermal and tribological properties predestine silicon carbide for the production of ceramic components of high volume. A novel method now overcomes the procedural and technical limitations of conventional design methods for the production of components with large differences in wall thickness and demanding undercuts.
Extremely hard as diamond, shrinking-free manufacturing, resistance to chemicals, wear and temperatures up to 1300 °C: Silicon carbide (SiSiC) bundles all...
In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...
The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.
As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...
25.03.2015 | Event News
19.03.2015 | Event News
17.03.2015 | Event News
01.04.2015 | Earth Sciences
01.04.2015 | Information Technology
01.04.2015 | Physics and Astronomy