Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Super-mini vehicles carry therapeutics and imaging agents into body with mega results

08.06.2011
Nanoscale, self assembly structures exploited for 21st century nanomedicine

Measured in billionths of a meter, self-assembling nano-sized devices designed to carry drugs and imaging agents into the body are revolutionizing medicine by improving drug solubility and bio-distribution, providing a platform for combining targeting and imaging agents, and enabling membrane barriers to be crossed as well as making drug and imaging agent combination therapies possible.

Self-assembling nano devices are now enlisted in the nanomedicine revolution, a story as told by researchers from Duke University and the University of Southern California in an article in the current TECHNOLOGY & INNOVATION, Proceedings of the National Academy of Inventors ™. (http://www.ingentaconnect.com/content/cog/ti/2011/00000013/00000001)

Their report covers two classes of self-assembled, nanoscale medical delivery devices currently used to transport drugs and also imaging materials across physiological barriers that they, acting by themselves, would be unable to cross.

"Nanoscale self-assembly devices are complex structures organized from simpler subcomponents - either naturally occurring or engineered - which assume complex structures difficult to attain by chemical synthesis," said the paper's corresponding author Dr. Ashutosh Chilkoti, professor of biomedical engineering at Duke University. "Their disassociation can be triggered by external stimuli, which serve as mechanisms to release therapeutic payloads."

According to Dr. Chilkoti and his co-authors, Dr. Mingan Chen and Jonathan R. McDaniel of the Duke University Department of Biomedical Engineering, as well as Dr. J. Andrew MacKay of the University of Southern California Department of Pharmacology and Pharmaceutical Sciences, many biological events rely on structures that self-assemble or disassemble based on environmental changes or physiological needs. Such natural self-assemblies used in nanomedicine rely on multiple weak forces, such as those associated with viral capsids and proteins.

Engineered self-assemblies used in nanomedicine come in over five groups of structural shapes, including the micellar nanostructure.

"We have recently developed a novel strategy that utilizes micelles self-assembled from recombinant polypeptides after attaching doxorubicin, a cancer drug, to deliver the drug," explained Dr. Chilkoti, who is also the director of the Duke University Center for Biologically Inspired Materials and Material Systems.

According to Dr. MacKay, a co-corresponding author of the report, the stability of micelles is important to their success or failure as drug delivery systems.

"The stability of micelles has thermodynamic and kinetic components," he said. "All factors that influence micellar stability can be tuned at the genetic level. Thus, we believe that genetically encoded polypeptide micelles are likely to play an increasing role in the design of next generation nanoscale carriers of drug and imaging agents."

In their report, the authors evaluate the structural and physiochemical properties, as well as the potential applications, of each type of structure.

The National Academy of Inventors ™ recognizes and encourages inventors who have a patent issued from the U.S. Patent and Trademark Office, enhances the visibility of university technology and academic innovation, encourages the disclosure of intellectual property, educates and mentors innovative students, and encourages the translation of the inventions of its members to benefit society.

The editorial offices of TECHNOLOGY and INNOVATION are located at the University of South Florida, Office of Research and Innovation, 3702 Spectrum Blvd., Suite 175, Tampa, Florida, 33612. Tel: (813) 974-3348. Email jlowry@research.usf.edu

News Release by Randolph Fillmore, Florida Science Communications, www.sciencescribe.net

Randolph Fillmore | EurekAlert!
Further information:
http://www.nasw.org

More articles from Medical Engineering:

nachricht Visualizing gene expression with MRI
23.12.2016 | California Institute of Technology

nachricht Illuminating cancer: Researchers invent a pH threshold sensor to improve cancer surgery
21.12.2016 | UT Southwestern Medical Center

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>