Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Spinal stimulation helps 4 patients with paraplegia regain voluntary movement

08.04.2014

Groundbreaking results bring new hope for those with spinal cord injury -- NIH study

Four people with paraplegia are able to voluntarily move previously paralyzed muscles as a result of a novel therapy that involves electrical stimulation of the spinal cord, according to a study funded in part by the National Institutes of Health and the Christopher & Dana Reeve Foundation.


Left to right is Andrew Meas, Dustin Shillcox, Kent Stephenson and Rob Summers, the first four to undergo task-specific training with epidural stimulation at the Human Locomotion Research Center laboratory, Frazier Rehab Institute, as part of the University of Louisville's Kentucky Spinal Cord Injury Research Center, Louisville, Kentucky.

Credit: Photo courtesy of the University of Louisville

The participants, each of whom had been paralyzed for more than two years, were able to voluntarily flex their toes, ankles, and knees while the stimulator was active, and the movements were enhanced over time when combined with physical rehabilitation. Researchers involved in the study say the therapy has the potential to change the prognosis of people with paralysis even years after injury.

"When we first learned that a patient had regained voluntary control as a result of spinal stimulation, we were cautiously optimistic," said Roderic Pettigrew, Ph.D., M.D., director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at NIH, which provided support for the study. "Now that spinal stimulation has been successful in 4 out of 4 patients, there is evidence to suggest that a large cohort of individuals, previously with little realistic hope of any meaningful recovery from spinal cord injury, may benefit from this intervention."

One of the most impressive and unexpected findings of the study is that two of the patients who benefited from the spinal stimulation had complete motor and sensory paralysis. In these patients, the pathway that sends information about sensation from the legs to the brain is disrupted, in addition to the pathway that sends information from the brain to the legs in order to control movement. The researchers were surprised by the outcome; they had assumed that at least some of the sensory pathway needed to be intact for the therapy to be effective.

The study is the continuation of a groundbreaking pilot trial initiated in 2009 to determine whether spinal stimulation, in conjunction with daily training on a treadmill, could help patients with paralysis regain some ability to move. In that trial, Rob Summers, a young man paralyzed below his chest, had a 16-electrode array implanted on his spinal cord. He then underwent daily training in which he was suspended in a harness over a treadmill while a team of researchers supported his legs, helping him to either stand or walk. At the same time, the array delivered electrical pulses to his spinal cord just below his injury.

According to the researchers, the goal of the stimulation was to increase the sensitivity of local circuits within the spinal cord that carry out basic motor functions without input from the brain—such as the knee jerk that occurs after stepping on a tack, or even more complex patterned movements like stepping. While not strong enough to directly induce muscle activation by itself, the researchers believed the stimulation could lead to movement when combined with sensory input from stepping on a treadmill.

With his stimulator active, Summers was able to gradually bear his own weight and could eventually stand without assistance from physical therapists for up to four minutes. Surprisingly, seven months into the trial, Summers also discovered that he had regained some voluntary control of his legs. The researchers were amazed by this latter outcome, as intentional movement requires information to travel from the brain down to the lower spinal cord, a path that had been rendered nonfunctional by his injury. Other impairments caused by Summers' injury also began to improve over time, in the absence of stimulation, such as blood pressure control, body temperature regulation, bladder control, and sexual function.

Now, in this follow-up study, Claudia Angeli, Ph.D., assistant professor at the University of Louisville's Kentucky Spinal Cord Injury Research Center and her research colleagues report that three additional patients with paralysis have recovered voluntary muscle control following electrical stimulation of the spine. Their report, which also includes results from new tests conducted on Summers, was published in the April 8 online issue of Brain.

The three patients in the new study include two with complete motor and sensory paralysis, and one, similar to Summers, with complete motor paralysis but some ability to experience sensation below his injury. Within just a few days of the start of stimulation, all three patients regained some voluntary control of previously paralyzed muscles.

The first person they implanted after Summers was unable to move or experience any sensation below his injury and was initially meant to be their baseline patient. "What was astounding about him was that not only was there voluntary movement, but we saw it in the first week of stimulation. We then saw it in the next two patients as well," said Susan Harkema, Ph.D., the director of rehabilitation research at the Kentucky Spinal Cord Injury Research Center at the University of Louisville, and a researcher in the study.

The researchers point to the speed at which each subject recovered voluntary movement as evidence that there may be dormant connections that exist in patients with complete motor paralysis. "Rather than there being a complete separation of the upper and lower regions relative to the injury, it's possible that there is some contact, but that these connections are not functional," said V. Reggie Edgerton, Ph.D., a UCLA distinguished professor of integrative biology and physiology, and the researcher responsible for developing the novel approach to rehabilitation. "The spinal stimulation could be reawakening these connections."

An important aspect of the new study involved assessing the ability of each patient to modulate his movements in response to auditory and visual cues. "We hoped to determine if they could voluntarily move in the presence of stimulation, and also how controlled they could be about their movements," said Angeli.

All participants, including Summers, were able to synchronize leg, ankle, and toe movements in unison with the rise and fall of a wave displayed on a computer screen, and three out of the four were able to change the force at which they flexed their leg, depending on the intensity of three different auditory cues.

"The fact that the brain is able to take advantage of the few connections that may be remaining, and then process this complicated visual, auditory, and perceptual information, is pretty amazing. It tells us that the information from the brain is getting to the right place in the spinal cord, so that the person can control, with fairly impressive accuracy, the nature of the movement," said Edgerton.

The same tests were also administered following several months of spinal stimulation applied in conjunction with locomotor training. During this time, patients also carried out home-based training, which consisted of hour-long stimulation while practicing intentional movements lying down. At the end of the training, some subjects were able to execute voluntary movements with greater force and with reduced stimulation, while others experienced enhanced movement accuracy. Harkema says it's unclear whether the improvement was a result of the training or due to the cumulative effects of stimulation over time. They plan to test this distinction in their next study.

"With this study the investigators show that their findings about a motor complete patient regaining movement, reported three years ago in The Lancet, were not an anomaly," said Susan Howley, executive vice president for research at the Christopher & Dana Reeve Foundation, Short Hills, N.J., which provides patient advocacy and funding for spinal cord injury research. "The implications of this study for the entire field are quite profound and we can now envision a day where epidural stimulation might be part of a cocktail of therapies used to treat paralysis."

With support from NIBIB, Edgerton, along with collaborators Joel Burdick and Y.C. Tai, professors of mechanical and electrical engineering and bioengineering at Caltech, are also working to develop a new high-density, 27-electrode array in rats to determine if it can provide finer, more robust control of locomotion.

"The technology we used in these four individuals was initially designed for the suppression of back pain, and our animal experiments have told us that we can do much better," said Edgerton. "For a given type of movement, we want to be able to select exactly where and how to stimulate the spinal cord. We just don't have that flexibility in the current technology."

Edgerton is also working with various collaborators on NIBIB-funded projects to explore whether epidural stimulation can be used to help patients with paralysis of the upper limbs. They are also developing a technology that can deliver spinal stimulation through the skin (transcutaneously), which would bypass the need for surgical implantation.

Though there is much work to be done, Harkema believes the results from this newest study already provide enough evidence to challenge currently held beliefs about the prognosis of patients with severe spinal cord injuries.

"Right now, the clinical perspective for individuals with complete motor paralysis is that there is nothing we can do," said Harkema "I think we need to rethink that. In our study, we demonstrated potential beyond any expectation. We need to relook at what the perceived potential is for this group of individuals."

"This is a wake-up call for how we see motor complete spinal cord injury," said Edgerton. "We don't have to necessarily rely on regrowth of nerves in order to regain function. The fact that we've observed this in all four patients suggests that this is actually a common phenomenon in those with complete paralysis."

###

This work was supported by the National Institute of Biomedical Imaging and Bioengineering and the National Institute of General Medical Sciences at NIH under the award numbers EB007615 and GM103507, the Christopher & Dana Reeve Foundation, the Kessler Foundation, the Leona M. and Harry B. Helmsley Charitable Trust, University of Louisville Foundation, and Jewish Hospital and St. Mary's Foundation, Frazier Rehab Institute and University Hospital.

NIBIB's mission is to improve health by leading the development and accelerating the application of biomedical technologies. The Institute is committed to integrating the physical and engineering sciences with the life sciences to advance basic research and medical care. NIBIB supports emerging technology research and development within its internal laboratories and through grants, collaborations, and training. More information is available at the NIBIB website: http://www.nibib.nih.gov.

NIGMS' mission is to support basic research to increase our understanding of life processes and lay the foundation for advances in disease diagnosis, treatment and prevention. For more information on the institute's research and training programs, see http://www.nigms.nih.gov.

The National Institutes of Health, the nation's medical research agency, includes 27 Institutes and Centers and is a component of the U.S. Department of Health and Human Services. NIH is the primary federal agency conducting and supporting basic, clinical, and translational medical research, and is investigating the causes, treatments, and cures for both common and rare diseases. For more information about NIH and its programs, visit http://www.nih.gov.

Margot Kern | EurekAlert!

Further reports about: Bioengineering Foundation NIBIB NIH connections injury movement movements paralysis sensory spinal treadmill

More articles from Medical Engineering:

nachricht A non-invasive tool for diagnosing cancer*
21.05.2015 | The Agency for Science, Technology and Research (A*STAR)

nachricht PolyU develops novel computer intelligence system for acute stroke detection
20.05.2015 | The Hong Kong Polytechnic University

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Lasers are the key to mastering challenges in lightweight construction

Many joining and cutting processes are possible only with lasers. New technologies make it possible to manufacture metal components with hollow structures that are significantly lighter and yet just as stable as solid components. In addition, lasers can be used to combine various lightweight construction materials and steels with each other. The Fraunhofer Institute for Laser Technology ILT in Aachen is presenting a range of such solutions at the LASER World of Photonics trade fair from June 22 to 25, 2015 in Munich, Germany, (Hall A3, Stand 121).

Lightweight construction materials are popular: aluminum is used in the bodywork of cars, for example, and aircraft fuselages already consist in large part of...

Im Focus: Solid-state photonics goes extreme ultraviolet

Using ultrashort laser pulses, scientists in Max Planck Institute of Quantum Optics have demonstrated the emission of extreme ultraviolet radiation from thin dielectric films and have investigated the underlying mechanisms.

In 1961, only shortly after the invention of the first laser, scientists exposed silicon dioxide crystals (also known as quartz) to an intense ruby laser to...

Im Focus: Advance in regenerative medicine

The only professorship in Germany to date, one master's programme, one laboratory with worldwide unique equipment and the corresponding research results: The University of Würzburg is leading in the field of biofabrication.

Paul Dalton is presently the only professor of biofabrication in Germany. About a year ago, the Australian researcher relocated to the Würzburg department for...

Im Focus: Basel Physicists Develop Efficient Method of Signal Transmission from Nanocomponents

Physicists have developed an innovative method that could enable the efficient use of nanocomponents in electronic circuits. To achieve this, they have developed a layout in which a nanocomponent is connected to two electrical conductors, which uncouple the electrical signal in a highly efficient manner. The scientists at the Department of Physics and the Swiss Nanoscience Institute at the University of Basel have published their results in the scientific journal “Nature Communications” together with their colleagues from ETH Zurich.

Electronic components are becoming smaller and smaller. Components measuring just a few nanometers – the size of around ten atoms – are already being produced...

Im Focus: IoT-based Advanced Automobile Parking Navigation System

Development and implementation of an advanced automobile parking navigation platform for parking services

To fulfill the requirements of the industry, PolyU researchers developed the Advanced Automobile Parking Navigation Platform, which includes smart devices,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International symposium: trends in spatial analysis and modelling for a more sustainable land use

20.05.2015 | Event News

15th conference of the International Association of Colloid and Interface Scientists

18.05.2015 | Event News

EHFG 2015: Securing health in Europe. Balancing priorities, sharing responsibilities

12.05.2015 | Event News

 
Latest News

Physicists precisely measure interaction between atoms and carbon surfaces

29.05.2015 | Physics and Astronomy

Godwits are flexible...when they get the chance

29.05.2015 | Life Sciences

Project start: New active substance targeting dreaded hospital pathogens

29.05.2015 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>