But this grid-like implant can slip out of position, closing off the windpipe altogether. Researchers are working on a special surface coating for the stents to keep them in place.
A new protein coating is designed not only to enhance incorporation of respiratory stents in the
surrounding tracheal tissue, but also to lower the risk of infection for patients. (© Leufen Medical GmbH )
When coronary blood vessels are constricted, cardiologists try to prevent a heart attack by widening them with small grid-like implants called stents, which stabilize the veins and arteries, improve the flow of blood and prevent vascular obliteration. A lesser known fact is that stents can be used to treat pathological constriction of the windpipe.
This kind of respiratory stenosis, which may be caused by tumors, chronic infections or congenital deformities, can be life-threatening. The metal or plastic stents are designed to enlarge the trachea and prevent it from closing up altogether.
But complications can arise when the implants are inserted. Firstly, there is the danger that the stents will shift, thus partially or completely obstructing the respiratory tract. Secondly, bacteria can colonize the stents and trigger pneumonia. The reason for this is that the stents have no barrier-forming cells of the kind usually present in the respiratory system, whose task is to fend off bacteria and inhaled substances such as particulate. “The windpipe has an important barrier function, with goblet and cilia cells purifying the inhaled air. It is very important that cells like these can adhere to the stents so as to maintain the air-purifying effect of the damaged section of the windpipe and to promote incorporation of the stents in the surrounding tracheal tissue,” says Dr. Martina Hampel, a scientist at the Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB in Stuttgart. Together with Prof. Dr. Thorsten Walles, head of the department of thoracic surgery at the University Hospital of Würzburg and a visiting scientist at the IGB, Dr. Hampel and her team took part in the “REGiNA” project, the goal of which was to develop surface coatings that enable the stents to be incorporated in the surrounding tissue, thus reducing the risk that they will move. REGiNA, a German acronym for Regenerative Medicine in the Neckar-Alb and Stuttgart Region, is funded by the German Federal Ministry of Education and Research BMBF.Bioactive coatings lower the risk for patients
The laboratory tests have since been completed, and animal tests are in preparation. If the good lab results are confirmed in these tests, the next step will be to conduct clinical trials of the modified stents at the Schillerhöhe specialist lung clinic, part of the Robert Bosch Hospital. “We hope that, within just a few years, our well-tolerated, cell-compatible surface coatings will be used for other biomedical prostheses such as pacemaker leads, tooth implants and replacement joints,” says Hampel.
Dr. rer. nat. Martina Hampel | Fraunhofer-Institute
Vanderbilt Team First to Blend High-End Imaging Techniques
17.03.2015 | Vanderbilt University Medical Center
Developing radically new technologies for X-ray systems
04.02.2015 | Siemens AG
In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...
The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.
As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...
When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.
The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe.
Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...
Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.
From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...
25.03.2015 | Event News
19.03.2015 | Event News
17.03.2015 | Event News
31.03.2015 | Life Sciences
31.03.2015 | Materials Sciences
31.03.2015 | Earth Sciences