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Screening for esophageal disease with unsedated transnasal endoscopy is safe and feasible

Researchers report that unsedated transnasal endoscopy is a feasible, safe, and well-tolerated method to screen for esophageal disease in a primary care population.

This study is the largest reported experience with transnasal endoscopy in the United States. The study appears in the May issue of GIE: Gastrointestinal Endoscopy, the monthly peer-reviewed scientific journal of the American Society for Gastrointestinal Endoscopy (ASGE).

Esophageal cancer is the most rapidly increasing type of neoplasia in terms of incidence in the United States over the last three decades. Endoscopic screening for esophageal neoplasia can identify patients who might benefit from early intervention for precancerous lesions. Unsedated transnasal endoscopy, also called transnasal esophagoscopy (TNE), may provide an efficient and accurate endoscopic assessment for esophageal neoplasia with fewer risks and less cost as compared with conventional upper endoscopy. Standard upper endoscopy allows for the identification of precancerous lesions or cancer of the esophagus, and is commonly performed with conscious sedation and occasionally with the patient under general anesthesia.

TNE uses ultrathin endoscopes that are passed through the patient's nose into the esophagus for performance of an upper endoscopy; typically the examination is carried out at least to the level of the proximal-to-mid stomach, depending on the height of the patient. Often, TNE can be performed without sedation through the use of topical anesthetics sprayed into the patient's nose and/or mouth. Avoiding intravenous sedation allows patients to drive following the examination and eliminates the need for a second person to accompany the patient to the examination. TNE procedures do not always result in complete upper endoscopy examinations, because a patient who is not sedated may not tolerate passage of the endoscope through the entire stomach, the duodenal bulb, and the second portion of the duodenum.

"Unsedated small-caliber TNE offers the possibility of efficient and accurate endoscopic assessment of the esophagus with less cost and fewer risks compared with sedated upper endoscopy. The sensitivity of detecting esophageal abnormalities with unsedated small-caliber TNE is comparable to that of conventional upper endoscopy," said study lead author Blair A. Jobe, MD, University of Pittsburgh Medical Center, Pittsburgh, Penn. "Studies in North America have been limited by small sample sizes and have been performed in populations selected for esophageal symptoms. These highly selected populations in referral settings have limited our ability to adequately risk stratify esophageal adenocarcinoma to achieve early detection and cure. Our study demonstrates that unsedated transnasal endoscopy is both feasible and safe in a primary care population, achieving short procedure times, a high diagnostic yield, and minimal anxiety. Patients reported good acceptability and minimal discomfort. These results suggest that we can now lower the threshold for endoscopic esophageal screening and with less cost."


The study assessed the feasibility, safety, acceptability, and yield of unsedated TNE in a primary care population. It was a multicenter, prospective, cross-sectional study conducted between 2009 and 2010 at two outpatient tertiary-care centers with a general medical clinic population aged between 40 and 85 years. The main outcome measurements included procedure yield; completeness of examination; procedure length; adverse events and complications; choking, gagging, pain, or anxiety during the examination; and overall tolerability.


A total of 426 participants enrolled in the study, and 422 (99 percent) completed the examination. Mean examination time was 3.7 minutes. There were no serious adverse events, and 12 participants (2.8 percent) reported minor complications. Participants reported minimal choking, gagging, pain, or anxiety. The examination was well-tolerated by most participants. Overall, 38 percent of participants had an esophageal finding that changed management (34 percent erosive esophagitis, 4 percent Barrett's esophagus). The majority of participants (70 percent) reported reflux or heartburn symptoms. Almost a third (29 percent) reported excess mucus in the nose or throat, and a quarter reported (25 percent) hoarseness. Approximately a fifth of participants reported globus (20 percent), chronic throat clearing (20 percent), chest pain (19 percent), or dysphagia (18 percent). Thirteen percent reported chronic sinusitis, 7 percent chronic sore throat, and 5 percent odynophagia.

The researchers noted that because two endoscopists with extensive experience in TNE performed the examinations, it is possible that patient tolerability would be lower with less experienced endoscopists. The study's authors concluded that unsedated TNE is a feasible, safe, and well-tolerated method to screen for esophageal disease in a primary care population and endoscopic findings are common in this patient population.

In an accompanying editorial, Douglas G. Adler, MD, FASGE, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, Utah, states, "Who should undergo TNE without sedation? Ideally, TNE should be considered in asymptomatic patients desiring screening for Barrett's esophagus based on family history or other factors. TNE might also be appropriate for patients with symptoms strongly suggestive of esophageal pathology in whom standard endoscopy is problematic or unappealing or in whom a complete upper endoscopy is not warranted. It will be interesting to see if the coming years see TNE without sedation enter mainstream practice and widespread use. Many factors are in play, ranging from the technical to financial, and the use of these devices in the outpatient clinic situation, although appealing, is not without limitations. Ultrathin endoscopes may be technical marvels, but their ideal role in day-to-day practice remains undetermined."

About the American Society for Gastrointestinal Endoscopy

Since its founding in 1941, the American Society for Gastrointestinal Endoscopy (ASGE) has been dedicated to advancing patient care and digestive health by promoting excellence and innovation in gastrointestinal endoscopy. ASGE, with more than 12,000 members worldwide, promotes the highest standards for endoscopic training and practice, fosters endoscopic research, recognizes distinguished contributions to endoscopy, and is the foremost resource for endoscopic education. Visit and for more information and to find a qualified doctor in your area.

About Endoscopy

Endoscopy is performed by specially-trained physicians called endoscopists using the most current technology to diagnose and treat diseases of the gastrointestinal tract. Using flexible, thin tubes called endoscopes, endoscopists are able to access the human digestive tract without incisions via natural orifices. Endoscopes are designed with high-intensity lighting and fitted with precision devices that allow viewing and treatment of the gastrointestinal system.

Anne Brownsey | EurekAlert!
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