From first tests on patients using the ‘photoacoustic mammoscope’ developed by the University of Twente, researcher dr. Srirang Manohar concludes that the images obtained add valuable information about the vascularisation of a tumor. The research has been done in cooperation with the Medisch Spectrum Twente hospital in Enschede, and the results are published in the online journal Optics Express.
In four out of five cases the photoacoustic images of the ‘suspect’ breast area show areas of high intensity around the tumor. The scientists attribute this to the vascularisation of the tumor: a tumor is fed by a large number of tiny blood vessels. These small vessels are not well visible on an X-ray mammogram, but they can indicate the malignancy of the tumor. In this way, photoacoustics has a potential in adding information to conventional X-ray and ultrasound mammography. In one of the cases now published in Optics Express, the X-ray apparently shows a benignant tumor, while the photoacoustic scan shows a ring-shaped area of high intensity: this may imply malignancy.Listening to light
The research published by dr. Srirang Manohar shows the usefulness of the new technique in imaging the vascularisation of the tumor. Further research is required to determine to what extent this new information tells more about the nature of the tumor. Larger scale clinical studies are required for that.
The research of dr. Srirang Manohar has been done within the BMTI Institute for Biomedical Technology of the University of Twente, together with the Surgery and Radiology departments of the Medical Spectrum Twente hospital in Enschede. Manohar is supported by the Dutch Technology Foundation STW and the Netherlands Organisation for Scientific Research NWO.
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