For the study, 170 patients with suspected coronary artery disease underwent CT-CA. The average vascular attenuation measured in the aortic root and in coronary arteries was used to divide the population into two groups of 85 patients each, one with low attenuations and one with high. The researchers found that the sensitivity and specificity for detecting artery lesions were 91% and 93%, respectively, for the low group and 96% and 97%, respectively for the high attenuation group.
"These results stress the importance of high intra-coronary attenuation during coronary CT angiography to achieve better diagnostic accuracy and therefore better diagnosis," said Filippo Cademartiri, MD, of Erasmus Medical Center, and one of the authors of the study. "As a result, a higher iodine concentration could be a means to increase diagnostic accuracy," he added.
However, the authors caution, high attenuation by itself is not the only issue that should be taken into consideration. "Other factors beside high attenuation are also important, especially in difficult patients (for instance, high body mass index, small coronary arteries, etc.). This information can be the difference between a diagnostic and a non-diagnostic investigation," said Dr. Cademartiri.
The full results of the study will be presented on Monday, May 7 by Erica Maffei, MD, of the Azienda Ospedaliero-Universitaria, during the American Roentgen Ray Society Annual Meeting in Orlando, FL.
Necoya Lightsey | EurekAlert!
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.
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We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
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