Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Lowering of blood pressure through use of hashish-like drug

19.06.2006
A new method for lowering blood pressure (hypertension) through use of a compound that synthesizes a cannabis (hashish) plant component has been developed by a pharmacology Ph.D. student at the Hebrew University of Jerusalem School of Pharmacy.

For his work on the cardiovascular activity of cannabinoids (chemical compounds derived from cannabis), Yehoshua Maor was one of the winners of this year’s Kaye Innovation Awards, presented on June 13 during the Hebrew University of Jerusalem’s 69th meeting of the Board of Governors.

Cardiovascular disease (CVD) accounts for about one-third of all deaths in industrialized countries, and is the leading reason for visits there to physicians as well as for drug prescriptions. However, not all patients respond well to the drugs available. There is no “ideal’ hypotensive (blood pressure lowering) drug.

The cannabis plant – also known as hashish or marijuana – through its chemical compounds -- cannabinoids -- has been shown to have a beneficial, hypotensive effect. However, a drawback in the therapeutic use of cannabinoids has been its undesirable psychotropic properties – production of hallucinatory effects. Attempts to separate the hypotensive action from the psychotropic properties of cannabinoids have achieved only partial success until now.

Working under the supervision of Prof. Raphael Mechoulam at the Hebrew University School of Pharmacy, Maor, who was born in Brazil and immigrated to Israel in 1998, has created a synthetic version of a minor cannabis constituent named cannabigerol, which is devoid of psychotropic activity.

In laboratory experiments with rats in collaboration with Prof. Michal Horowitz of the Department of Environmental Physiology, it was found that this novel compound reduced blood pressure when administered to the rats in relatively low doses. Additional testing also showed that the compound also brought about another beneficial effect -- relaxation of the blood vessels. A further beneficial property observed in work carried out with Prof. Ruth Gallily of the Lautenberg Center for General and Tumor Immunology, was that the compounds produced an anti-inflammatory response.

Maor believes that these qualities have the potential for development of a valuable new clinical drug with a major market potential, especially for patients suffering from inflammation of the blood vessels as the result of hypertension, and others with metabolic irregularities.

Maor already has won international recognition for his work with cannabanoids, resulting from his collaborative work with Garry Milman, another Ph.D. student in the laboratory of Prof. Mechoulam, for the discovery of an endogenous compound found in the brain which causes vaso-relaxation.

Maor begin a post-doctoral fellowship in the fall at the Harvard University Medical School, where he plans to continue his research.

The Kaye Innovation Awards have been given annually since 1994. Isaac Kaye of England, a prominent industrialist in the pharmaceutical industry, established the awards to encourage faculty, staff and students of the Hebrew University to develop innovative methods and inventions with good commercial potential which will benefit the university and society.

Jerry Barach | alfa
Further information:
http://www.huji.ac.il

More articles from Medical Engineering:

nachricht 'Memtransistor' brings world closer to brain-like computing
22.02.2018 | Northwestern University

nachricht MRI technique differentiates benign breast lesions from malignancies
20.02.2018 | Radiological Society of North America

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

Im Focus: Hybrid optics bring color imaging using ultrathin metalenses into focus

For photographers and scientists, lenses are lifesavers. They reflect and refract light, making possible the imaging systems that drive discovery through the microscope and preserve history through cameras.

But today's glass-based lenses are bulky and resist miniaturization. Next-generation technologies, such as ultrathin cameras or tiny microscopes, require...

Im Focus: Stem cell divisions in the adult brain seen for the first time

Scientists from the University of Zurich have succeeded for the first time in tracking individual stem cells and their neuronal progeny over months within the intact adult brain. This study sheds light on how new neurons are produced throughout life.

The generation of new nerve cells was once thought to taper off at the end of embryonic development. However, recent research has shown that the adult brain...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Stiffness matters

22.02.2018 | Life Sciences

Magnetic field traces gas and dust swirling around supermassive black hole

22.02.2018 | Physics and Astronomy

First evidence of surprising ocean warming around Galápagos corals

22.02.2018 | Earth Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>