Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Implantable defibrillators save lives but may increase heart failure risk

14.06.2006
American Heart Association rapid access journal report

Implantable cardioverter defibrillators (ICDs) reduce the risk of sudden cardiac death but may increase the risk of subsequent heart failure in patients who live longer, according to a study published in Circulation: Journal of the American Heart Association.

"Some patients whose lives were prolonged by ICDs were sicker and more prone to develop heart failure," said Ilan Goldenberg, M.D., research assistant professor at the University of Rochester Medical Center and lead author of the latest report from the Multicenter Automatic Defibrillator Implantation Trial-II (MADIT-II). "The ICD kept them alive by preventing sudden cardiac death as their heart disease naturally progressed to heart failure.

"Patients who developed heart failure had almost four times the increase in risk of death during follow up. This study should direct more attention to the prevention of heart failure in patients receiving an ICD."

The MADIT-II trial included 1,232 heart attack patients with an ejection fraction of 30 percent or less who had a heart attack at least a month before enrollment. Researchers randomly assigned patients to ICD (single or dual chamber) or best medical care.

Ejection fraction is a measure of the heart's ability to efficiently pump blood to other parts of the body. An ejection fraction of 60 percent is healthy, so the MADIT-II patients were pumping blood at about half the rate of healthy people.

Compared to patients who received only medical therapy after a heart attack, those who had ICDs implanted were 39 percent more likely to have a first hospitalization for heart failure and 58 percent more likely to be hospitalized for recurrent heart failure during an average 20-month follow up.

The overall survival benefit was 42 percent for patients who received a single chamber ICD and 51 percent for those with a dual chamber. Researchers analyzed data from 1,224 study patients, including 402 who received single-chamber devices and 313 who were implanted with dual-chamber devices.

Twenty-three percent of patients who received ICDs in the MADIT-II trial were hospitalized for HF during 20 months of follow-up versus 17 percent of patients who received only medical therapy.

Patients who received single-chamber devices did not suffer a reduced survival benefit if they developed heart failure. However, patients who were implanted with dual-chamber devices had a significant reduction in survival benefit after heart failure, Goldenberg said.

Karen Astle | EurekAlert!
Further information:
http://www.heart.org

More articles from Medical Engineering:

nachricht Heart examinations: Miniature particle accelerator saves on contrast agents
27.02.2017 | Technische Universität München

nachricht Novel breast tomosynthesis technique reduces screening recall rate
21.02.2017 | Radiological Society of North America

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

New pop-up strategy inspired by cuts, not folds

27.02.2017 | Materials Sciences

Sandia uses confined nanoparticles to improve hydrogen storage materials performance

27.02.2017 | Interdisciplinary Research

Decoding the genome's cryptic language

27.02.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>