Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Implantable defibrillators save lives but may increase heart failure risk

14.06.2006
American Heart Association rapid access journal report

Implantable cardioverter defibrillators (ICDs) reduce the risk of sudden cardiac death but may increase the risk of subsequent heart failure in patients who live longer, according to a study published in Circulation: Journal of the American Heart Association.

"Some patients whose lives were prolonged by ICDs were sicker and more prone to develop heart failure," said Ilan Goldenberg, M.D., research assistant professor at the University of Rochester Medical Center and lead author of the latest report from the Multicenter Automatic Defibrillator Implantation Trial-II (MADIT-II). "The ICD kept them alive by preventing sudden cardiac death as their heart disease naturally progressed to heart failure.

"Patients who developed heart failure had almost four times the increase in risk of death during follow up. This study should direct more attention to the prevention of heart failure in patients receiving an ICD."

The MADIT-II trial included 1,232 heart attack patients with an ejection fraction of 30 percent or less who had a heart attack at least a month before enrollment. Researchers randomly assigned patients to ICD (single or dual chamber) or best medical care.

Ejection fraction is a measure of the heart's ability to efficiently pump blood to other parts of the body. An ejection fraction of 60 percent is healthy, so the MADIT-II patients were pumping blood at about half the rate of healthy people.

Compared to patients who received only medical therapy after a heart attack, those who had ICDs implanted were 39 percent more likely to have a first hospitalization for heart failure and 58 percent more likely to be hospitalized for recurrent heart failure during an average 20-month follow up.

The overall survival benefit was 42 percent for patients who received a single chamber ICD and 51 percent for those with a dual chamber. Researchers analyzed data from 1,224 study patients, including 402 who received single-chamber devices and 313 who were implanted with dual-chamber devices.

Twenty-three percent of patients who received ICDs in the MADIT-II trial were hospitalized for HF during 20 months of follow-up versus 17 percent of patients who received only medical therapy.

Patients who received single-chamber devices did not suffer a reduced survival benefit if they developed heart failure. However, patients who were implanted with dual-chamber devices had a significant reduction in survival benefit after heart failure, Goldenberg said.

Karen Astle | EurekAlert!
Further information:
http://www.heart.org

More articles from Medical Engineering:

nachricht PET identifies which prostate cancer patients can benefit from salvage radiation treatment
05.12.2017 | Society of Nuclear Medicine and Molecular Imaging

nachricht Designing a golden nanopill
01.12.2017 | University of Texas at Austin, Texas Advanced Computing Center

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-of-its-kind chemical oscillator offers new level of molecular control

DNA molecules that follow specific instructions could offer more precise molecular control of synthetic chemical systems, a discovery that opens the door for engineers to create molecular machines with new and complex behaviors.

Researchers have created chemical amplifiers and a chemical oscillator using a systematic method that has the potential to embed sophisticated circuit...

Im Focus: Long-lived storage of a photonic qubit for worldwide teleportation

MPQ scientists achieve long storage times for photonic quantum bits which break the lower bound for direct teleportation in a global quantum network.

Concerning the development of quantum memories for the realization of global quantum networks, scientists of the Quantum Dynamics Division led by Professor...

Im Focus: Electromagnetic water cloak eliminates drag and wake

Detailed calculations show water cloaks are feasible with today's technology

Researchers have developed a water cloaking concept based on electromagnetic forces that could eliminate an object's wake, greatly reducing its drag while...

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

Engineers program tiny robots to move, think like insects

15.12.2017 | Power and Electrical Engineering

One in 5 materials chemistry papers may be wrong, study suggests

15.12.2017 | Materials Sciences

New antbird species discovered in Peru by LSU ornithologists

15.12.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>