Measuring the biochemical changes in breast tumors with magnetic resonance (MR) spectroscopy enables radiologists to more accurately distinguish benign tumors from cancerous ones, according to a study appearing in the August issue of the journal Radiology.
"Adding spectroscopy to breast MR examinations will not only reduce concern over possible missed cancers and unnecessary biopsy procedures, it may also improve the efficiency and quality of patient care," said co-author Sina Meisamy, M.D., a postdoctoral fellow at the University of Minnesota Center for Magnetic Resonance Research in Minneapolis.
MR imaging of the breasts has a high rate of sensitivity (94 percent – 100 percent) for detecting tumors, but a variable rate of specificity (37 percent – 97 percent) for distinguishing malignant from benign tumors.
MR spectroscopy uses the same magnet and electronics as MR imaging, but with specialized methods that produce a "spectrum" identifying different chemical compounds in the tissues. MR spectroscopy has been shown to be useful for looking at various disorders, including cancer, Alzheimer’s disease, diabetes and certain inflammatory and ischemic diseases. Generally used for the brain, spectroscopy poses no known health risk to patients and typically adds only seven to 10 minutes to the MR procedure.
For the study, four radiologists evaluated 55 breast MR imaging cases that had findings confirmed through earlier biopsies. The evaluations were done with and without MR spectroscopy. The addition of spectroscopy resulted in more cancerous tumors detected (from 87 percent to 94 percent), a higher success rate for distinguishing benign from malignant tumors (from 51 percent to 57 percent) and a greater agreement among the radiologists on their findings. Also, with the addition of spectroscopic readings, two of the four radiologists had significantly improved sensitivity to detect cancerous tumors and all four participants achieved significantly improved accuracy in assigning a probability of malignancy.
"Spectroscopy gives us an additional piece of information about the biochemical composition of the tumor," explained senior author Michael Garwood, Ph.D., associate director of the Center for Magnetic Resonance Research and the Lillian Quist - Joyce Henline Chair in Biomedical Research Professor of Radiology at the University of Minnesota. "When the standard MR imaging exam is inconclusive, the spectroscopy measurement can improve the rate of detecting a cancerous breast tumor."
Doug Dusik | EurekAlert!
Novel breast tomosynthesis technique reduces screening recall rate
21.02.2017 | Radiological Society of North America
Biocompatible 3-D tracking system has potential to improve robot-assisted surgery
17.02.2017 | Children's National Health System
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
24.02.2017 | Life Sciences
24.02.2017 | Life Sciences
24.02.2017 | Trade Fair News