Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Computer simulations help predict fracture risk

02.07.2008
Using a Blue Gene supercomputer, scientists of ETH Zurich and the IBM Zurich Research Laboratory demonstrated the most extensive simulation yet of actual human bone structure. This achievement may lead to better clinical tools to improve the diagnosis and treatment of osteoporosis, a widespread disease that worldwide affects 1 in 3 women and 1 in 5 men over the age of 50.

With the goal of developing an accurate, powerful and fast method to automate the analysis of bone strength, scientists of the ETH Zurich Departments of Mechanical and Process Engineering and Computer Science teamed up with supercomputing experts at IBM's Zurich Research Laboratory. The breakthrough method developed by the team combines density measurements with a large-scale mechanical analysis of the innerbone microstructure.

Using large-scale, massively parallel simulations, the researchers were able to obtain a dynamic "heat map" of strain, which changes with the load applied to the bone. This map shows the clinician exactly where and under what load a bone is likely to fracture. "With that knowledge, a clinician can also detect osteoporotic damage more precisely and, by adjusting a surgical plate appropriately, can best determine the location of the damage," explains Dr. Costas Bekas of IBM's Computational Sciences team in Zurich. "This work is an excellent showcase of the dramatic potential that supercomputers can have for our everyday lives."

The joint team utilized the massively large-scale capabilities of the 8-rack Blue Gene /L supercomputer to conduct the first simulations on a 5 by 5 mm specimen of real bone. Within 20 minutes, the supercomputer simulation generated 90 Gigabytes of output data. "It is this combination of increased speed and size that will allow solving clinically relevant cases in acceptable time and unprecedented detail", says Professor Ralph Müller, Director of the ETH Zurich Institute for Biomechanics.

Going beyond static bone strength

Ten years ago, the world's most sophisticated supercomputer, called Deep Blue, would not have been able to handle the sheer size of the calculations. Even with sufficient system memory, it would have taken roughly a week of computing time - too long for meaningful impact on diagnosis and treatment.

"Ten years from now, today's supercomputers' performance will be available in desktop systems, making such simulations of bone strength a routine practice in computer tomography," predicts Dr. Alessandro Curioni, manager of the Computational Sciences group at IBM's Zurich Research Laboratory.

ETH Zurich Professor Peter Arbenz, who initiated the collaboration of the involved groups, explains that what was first needed was state of the art in numerical algorithms in order to solve extremely large problems in surprisingly short time, and that it is the first fundamental step towards clinical use of large scale bone simulations. "We are at the beginning of an exciting journey. This line of research must absolutely be continued in order to achieve our goal," he states. Scientists in future aim to advance simulation techniques to go beyond the calculation of static bone strength to the simulation of the actual formation of the fractures for individual patients, in yet another step towards the fast, reliable and early detection of people at high fracture risk.

Reference
The work "Extreme Scalability Challenges in Analyses of Human Bone Structures" by ETH scientists Peter Arbenz, Cyril Flaig, Harry van Lenthe, Ralph Mueller, Andreas Wirth and ZRL researchers Costas Bekas and Alessandro Curioni was presented at the IACM/ECCOMAS 2008 conference in Venice, Italy, on July 2.

Roman Klingler | idw
Further information:
http://www.ethz.ch
http://www.cc.ethz.ch/media/picturelibrary/news/osteoporose

More articles from Medical Engineering:

nachricht Rutgers researchers develop automated robotic device for faster blood testing
14.06.2018 | Rutgers University

nachricht Speech comprehension with a cochlear implant
04.06.2018 | Universität zu Lübeck

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Temperature-controlled fiber-optic light source with liquid core

In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.

Already last year, the researchers provided experimental proof of a new dynamic of hybrid solitons– temporally and spectrally stationary light waves resulting...

Im Focus: Overdosing on Calcium

Nano crystals impact stem cell fate during bone formation

Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...

Im Focus: AchemAsia 2019 will take place in Shanghai

Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.

Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...

Im Focus: First real-time test of Li-Fi utilization for the industrial Internet of Things

The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.

Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.

Im Focus: Sharp images with flexible fibers

An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.

Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Munich conference on asteroid detection, tracking and defense

13.06.2018 | Event News

2nd International Baltic Earth Conference in Denmark: “The Baltic Sea region in Transition”

08.06.2018 | Event News

ISEKI_Food 2018: Conference with Holistic View of Food Production

05.06.2018 | Event News

 
Latest News

Creating a new composite fuel for new-generation fast reactors

20.06.2018 | Materials Sciences

Game-changing finding pushes 3D-printing to the molecular limit

20.06.2018 | Materials Sciences

Could this material enable autonomous vehicles to come to market sooner?

20.06.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>