The research team examined glycosaminogycans (GAGs), which are molecules that serve as the building blocks of cartilage and are involved in numerous vital functions in the human body. Mapping the GAG concentration in vivo, or in a living organism, is desirable for the diagnosis and monitoring of a number of diseases. It is also valuable in determining the efficacy of drug therapies. For instance, GAG loss in cartilage typically marks the onset of osteoarthritis and inter-vertebral disc degeneration.
However, the existing techniques for GAG monitoring—based on traditional magnetic resonance imaging (MRI)—have limitations: they cannot directly map GAG concentrations or they require the administration of contrast agents. The NYU-Tel Aviv research team sought a more direct measurement of GAGs. In this study, they employed the exchangeable protons of GAG to directly measure GAG concentration in vivo.
Knowing that GAG molecules have proton groups that are not tethered tightly, the researchers investigated whether proton exchange in GAGs could allow concentrations of the molecule to be measured by the MRI. By separating out the GAG protons from those of water, they can be used as a sort of inherent contrast agent. Testing the idea in tissue samples, the researchers found that the available GAG protons provided an effective type of contrast enhancement, allowing them to readily monitor GAGs through a clinical MRI scanner. The in vivo application of this method showed that this technique can be readily implemented in a clinical setting.
This chemical exchange saturation method (gagCEST) not only could provide a non-invasive way to diagnose osteoarthritis in its very early stages, but could also help to indicate early interventions for degenerative disc disease, which is responsible for lower back pain, and defects in heart valves and, potentially, the cornea.
James Devitt | EurekAlert!
Münster researchers make a fly’s heartbeat visible / Software automatically recognizes pulse
12.03.2018 | Westfälische Wilhelms-Universität Münster
3-D-written model to provide better understanding of cancer spread
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Satellites in near-Earth orbit are at risk due to the steady increase in space debris. But their mission in the areas of telecommunications, navigation or weather forecasts is essential for society. Fraunhofer FHR therefore develops radar-based systems which allow the detection, tracking and cataloging of even the smallest particles of debris. Satellite operators who have access to our data are in a better position to plan evasive maneuvers and prevent destructive collisions. From April, 25-29 2018, Fraunhofer FHR and its partners will exhibit the complementary radar systems TIRA and GESTRA as well as the latest radar techniques for space observation across three stands at the ILA Berlin.
The "traffic situation" in space is very tense: the Earth is currently being orbited not only by countless satellites but also by a large volume of space...
An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
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