The research team examined glycosaminogycans (GAGs), which are molecules that serve as the building blocks of cartilage and are involved in numerous vital functions in the human body. Mapping the GAG concentration in vivo, or in a living organism, is desirable for the diagnosis and monitoring of a number of diseases. It is also valuable in determining the efficacy of drug therapies. For instance, GAG loss in cartilage typically marks the onset of osteoarthritis and inter-vertebral disc degeneration.
However, the existing techniques for GAG monitoring—based on traditional magnetic resonance imaging (MRI)—have limitations: they cannot directly map GAG concentrations or they require the administration of contrast agents. The NYU-Tel Aviv research team sought a more direct measurement of GAGs. In this study, they employed the exchangeable protons of GAG to directly measure GAG concentration in vivo.
Knowing that GAG molecules have proton groups that are not tethered tightly, the researchers investigated whether proton exchange in GAGs could allow concentrations of the molecule to be measured by the MRI. By separating out the GAG protons from those of water, they can be used as a sort of inherent contrast agent. Testing the idea in tissue samples, the researchers found that the available GAG protons provided an effective type of contrast enhancement, allowing them to readily monitor GAGs through a clinical MRI scanner. The in vivo application of this method showed that this technique can be readily implemented in a clinical setting.
This chemical exchange saturation method (gagCEST) not only could provide a non-invasive way to diagnose osteoarthritis in its very early stages, but could also help to indicate early interventions for degenerative disc disease, which is responsible for lower back pain, and defects in heart valves and, potentially, the cornea.
James Devitt | EurekAlert!
Rutgers researchers develop automated robotic device for faster blood testing
14.06.2018 | Rutgers University
Speech comprehension with a cochlear implant
04.06.2018 | Universität zu Lübeck
In a recent publication in the renowned journal Optica, scientists of Leibniz-Institute of Photonic Technology (Leibniz IPHT) in Jena showed that they can accurately control the optical properties of liquid-core fiber lasers and therefore their spectral band width by temperature and pressure tuning.
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Scientists from the University of Freiburg and the University of Basel identified a master regulator for bone regeneration. Prasad Shastri, Professor of...
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
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The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
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