New Applications for OCT Could Improve Care for Women in Labor and People with Diabetic Retinopathy and Glaucoma
The march of modern medicine is often driven by revolutions in medical imaging. When technology advances, doctors are better able to peer deeply into human tissues, and thus able to detect, diagnose and treat human diseases more effectively.
Now, researchers have taken an established imaging technology called “optical coherence tomography,” or OCT, and integrated it with other instruments to bring about the next revolution in imaging by helping doctors provide safer, less painful and more effective care for women in labor and people with diabetic retinopathy and glaucoma. Their research will be presented at CLEO: 2014 being held June 8-13 in San Jose, California, USA.
OCT uses scattered “echoes” or reflections of light waves to produce high-resolution images of biological tissues, similar to ultrasound imaging but with one order of magnitude improvement in the resolution. Ophthalmologists have been using OCT to examine the retina for years.
Results of OCT-guided insertion. A)The porcine spine used for experiment. B) Anatomy of lumbar spine (sagittal view). C) Images acquired by GRIN needle device corresponding to different tissues. Credit: Qinggong Tang
More recently, OCT has been applied to a number of other clinical specialties, including oncology for early cancer detection and staging in the gastrointestinal and urogenital tract as well as in cardiology, where it is used to study the formation of plaques in coronary arteries in situ.
Bioengineer Yu Chen of the University of Maryland and his colleagues have developed a way to integrate an OCT device with an 18-gauge epidural needle. Epidural administration, Chen notes, is traditionally done blindly, using anatomical landmarks. But the team’s newly miniaturized handheld device lets anesthesiologists see tissue from the perspective of the tip of the epidural needle, which could help doctors to deliver spinal anesthetic to patients with less pain and fewer complications.
“Due to lack of visual feedback, failure rates are often high, leading to multiple needle insertions,” he says. Side effects of these failures can include trauma to blood vessels and punctures in the dura, the outermost membrane surrounding the brain and spinal cord.
“An OCT forward-imaging probe can provide anesthesiologists with real-time visualization of the microarchitecture of tissues and important landmarks, and thus could significantly improve the accuracy and the safety of the needle-based procedure,” Chen says.
The researchers have been successful in testing needle-guidance experiments on pig swine samples and hope to conduct a pre-clinical study of the device within the next year.
Presentation AM2O.3, titled “Real-time Epidural Anesthesia Guidance Using Optical Coherence Tomography Needle Probe will take place Monday, June 9, at 11:15 a.m. in Salon V & VI of the San Jose Convention Marriott.
Better blood monitors
A team at the University of California, Davis, led by Biomedical Engineer Vivek Srinivasan has shown how OCT can simultaneously measure blood flow and blood oxygenation in vessels, without the need for contrast agents.
Like ultrasound, OCT can provide structural information, but it can also be used to determine flow rates and for angiography, visualizing the interior of blood vessels, says Shau Poh Chong, a postdoctoral researcher in the Srinivasan lab.
“Conventional pulse oximetry measures oxygen saturation using transmitted light,” Chong says. “Performing these measurements quantitatively with reflected light has traditionally been difficult due to the unknown distance traveled by the light through scattering tissue.”
OCT directly determines the distance that light travels. Until now, however, it was difficult to use OCT to measure oxygen saturation in blood, due to additional modeling errors introduced by light scattering. At visible wavelengths, scattering is much lower relative to blood absorption than at infrared wavelengths, where OCT is typically performed. The OCT system developed in the Srinivasan lab uses broadband visible light to measure the amounts of both oxygenated and deoxygenated hemoglobin, the oxygen-carrying protein of blood, thus revealing oxygen saturation levels. In addition, the team developed new methods to further reduce modeling errors caused by light scattering.
“The broad set of measurements provided by the system, including angiography, oximetry and red blood cell flow rates enables the direct assessment of tissue oxygen metabolism, which is essential for understanding the evolution of oxygen supply and demand in numerous disease models,” Chong says. “In the future, these techniques could be applied to study metabolic changes in diseases that affect the human retina, such as diabetic retinopathy and glaucoma.”
Presentation ATh1O.2, titled “Optical Coherence Imaging of Microvascular Oxygenation and Hemodynamics will take place Thursday, June 12, at 8:30 a.m. in Willow Glen I - III of the San Jose Convention Marriott.
PRESS REGISTRATION: A press room for credentialed press and analysts will be located in the San Jose Convention Center, Sunday through Thursday, June 8-12. Those interested in obtaining a press badge for CLEO: 2014 should contact Lyndsay Meyer at 202.416.1435 or firstname.lastname@example.org.
With a distinguished history as the industry's leading event on laser science, the Conference on Lasers and Electro-Optics (CLEO) is the premier international forum for scientific and technical optics, uniting the fields of lasers and opto-electronics by bringing together all aspects of laser technology, from basic research to industry applications. CLEO: Expo showcases the latest products and applications from more than 300 participating companies from around the world, providing hands-on demonstrations of the latest market innovations and applications. The Expo also offers valuable on-floor programming, including Market Focus and the Technology Transfer program.
Sponsored by the American Physical Society's (APS) Laser Science Division, IEEE Photonics Society and The Optical Society (OSA), CLEO provides the full range of critical developments in the field, showcasing the most significant milestones from laboratory to marketplace. With an unparalleled breadth and depth of coverage, CLEO connects all of the critical vertical markets in lasers and electro-optics. For more information, visit www.cleoconference.org. CLEO: 2014 takes place June 8 - 13 at the San Jose Convention Center.
Lyndsay Meyer | Eurek Alert!
First transcatheter implant for diastolic heart failure successful
16.11.2017 | The Ohio State University Wexner Medical Center
Theranostic nanoparticles for tracking and monitoring disease state
13.11.2017 | SLAS (Society for Laboratory Automation and Screening)
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.
During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....
The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.
Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...
Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
20.11.2017 | Earth Sciences
20.11.2017 | Earth Sciences
20.11.2017 | Life Sciences