Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

One small chip -- one giant leap forward for early cancer detection

19.05.2014

An ultra-sensitive nano-chip capable of detecting cancer at early stages

Today, the majority of cancers are detected on the macroscopic level, when the tumor is already composed of millions of cancer cells and the disease is starting to advance into a more mature phase. But what if we could diagnose cancer before it took hold- while it was still only affecting a few localized cells? It would be like putting a fire out while it was still just a few sparks versus after having already caught on and spread to many areas of the house.


This shows the lab-on-a-chip.

Credit: ICFO - the Institute of Photonic Sciences


This shows gold Nano-particles in fluidic micro-channels attracting protein cancer markers.

Credit: ICFO - The Institute of Photonic Sciences

An international team of researchers, led by ICFO- Institute of Photonic Sciences in Castelldefels, announce the successful development of a "lab-on-a-chip" platform capable of detecting protein cancer markers in the blood using the very latest advances in plasmonics, nano-fabrication, microfluids and surface chemistry. The device is able to detect very low concentrations of protein cancer markers in blood, enabling diagnoses of the disease in its earliest stages. The detection of cancer in its very early stages is seen as key to the successful diagnosis and treatment of this disease.

This cancer-tracking nano-device shows great promise as a tool for future cancer treatments, not only because of its reliability, sensitivity and potential low cost, but also because of its easy carry-on portable properties, which is foreseen to facilitate effective diagnosis and suitable treatment procedures in remote places with difficult access to hospitals or medical clinics.

HOW DOES IT WORK: Although very compact (only a few square centimeters), the lab-on-a-chip hosts various sensing sites distributed across a network of fluidic micro-channels that enables it to conduct multiple analyses. Gold nano-particles lie on the surface of the chip and are chemically programed with an antibody receptor in such a way that they are capable of specifically attracting the protein markers circulating in blood.

When a drop of blood is injected into the chip, it circulates through the micro-channels and if cancer markers are present in the blood, they will stick to the nano-particles located on the micro-channels as they pass by, setting off changes in what is known as the "plasmonic resonance". The device monitors these changes, the magnitude of which are directly related to the concentration/number of markers in the patient blood thus providing a direct assessment of the risk for the patient to develop a cancer.

ICREA Professor at ICFO Romain Quidant, coordinator of the project comments, "the most fascinating finding is that we are capable of detecting extremely low concentrations of this protein in a matter of minutes, making this device an ultra-high sensitivity, state-of-the-art, powerful instrument that will benefit early detection and treatment monitoring of cancer". In 2009, Prof. Quidant's research group at ICFO, in collaboration with several groups of oncologists, joined the worldwide effort devoted to the ultra-sensitive detection of protein markers located on the surface of cancer cells and in peripheral blood, which had been determined to be a clear indicator of the development of cancer.

In 2010, they successfully obtained funding for the project called SPEDOC (Surface Plasmon Early Detection of Circulating Heat Shock Proteins and Tumor Cells) under the 7th Framework Program (FP7) of the European Commission. The effort was also boosted by generous philanthropic support from Cellex Foundation Barcelona. Today's announcement is an important outcome of this project.

###

About this study

This work has been supported by Cellex Foundation Barcelona and by the SPEDOC project, funded by the Seventh Framework Program (FP7) of the European Commission.

Reference: Srdjan S Acimovic , Maria Alejandra Ortega , Vanesa Sanz , Johann Berthelot , Jose Luis Garcia-Cordero , Jan Renger , Sebastian J. Maerkl , Mark Patrick Kreuzer , and Romain Quidant, LSPR Chip for Parallel, Rapid and Sensitive Detection of Cancer Markers in Serum, Nano Letters, DOI: 10.1021/nl500574n

About ICFO

ICFO-The Institute of Photonic Sciences was created in 2002 by the government of Catalonia and the Technical University of Catalonia as a center of research excellence devoted to the science and technologies of light with a triple mission: to conduct frontier research, train the next generation of scientists, and provide knowledge and technology transfer. Today, it is one of the top research centres worldwide in its category as measured by the Mapping Scientific Excellence ranking.

Research at ICFO targets the forefront of science and technology based on light with programs directed at applications in Health, Renewable Energies, Information Technologies, Security and Industrial processes, among others. The institute hosts 300 professionals based in a dedicated building situated in the Mediterranean Technology Park in the metropolitan area of Barcelona.

Researchers at ICFO publish in the most prestigious journals and collaborate with a wide range of companies around the world. The institute runs a vigorous technology transfer program in which more than 30 national and international industries participate. It has also created 5 spin-off companies to date. The institute is generously supported by Cellex Foundation Barcelona, which supports several frontier research projects and programs focused on young talented researchers.

Links:

Videos:

Alina Hirschmann | Eurek Alert!

Further reports about: Catalonia Detection Framework ICFO One Photonic blood concentrations created markers nano-particles sensitivity watch

More articles from Medical Engineering:

nachricht Tiny mechanical wrist gives new dexterity to needlescopic surgery
24.07.2015 | Vanderbilt University

nachricht Printing implants with the laser
21.07.2015 | Laser Zentrum Hannover e.V.

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

Im Focus: Unlocking the rice immune system

Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight

A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...

Im Focus: Smarter window materials can control light and energy

Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.

By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...

Im Focus: Simulations lead to design of near-frictionless material

Argonne scientists used Mira to identify and improve a new mechanism for eliminating friction, which fed into the development of a hybrid material that exhibited superlubricity at the macroscale for the first time. Argonne Leadership Computing Facility (ALCF) researchers helped enable the groundbreaking simulations by overcoming a performance bottleneck that doubled the speed of the team's code.

While reviewing the simulation results of a promising new lubricant material, Argonne researcher Sanket Deshmukh stumbled upon a phenomenon that had never been...

Im Focus: NASA satellite camera provides 'EPIC' view of Earth

A NASA camera on the Deep Space Climate Observatory (DSCOVR) satellite has returned its first view of the entire sunlit side of Earth from one million miles away.

The color images of Earth from NASA's Earth Polychromatic Imaging Camera (EPIC) are generated by combining three separate images to create a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

 
Latest News

Possible Path Toward First Anti-MERS Drugs

28.07.2015 | Life Sciences

Smart Hydrogel Coating Creates “Stick-slip” Control of Capillary Action

28.07.2015 | Materials Sciences

Are Fish Getting High on Cocaine?

28.07.2015 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>