By using these techniques during patient exams to identify OA earlier, clinicians can shift the management of the disease from eventual joint reconstruction to long-term preservation. The study was published in the July issue of the Journal of the American Academy of Orthopaedic Surgeons.
"Imaging technology is now sensitive and powerful enough to enable detection of subtle changes in the intricate balance of water, chondrocytes and the collagen fibers and protein molecules that make up our joint cartilage – which we now know can point to future osteoarthritis," says Laith Jazrawi, MD, associate professor of orthopaedic surgery and lead author of the paper. "With an active and aging baby boomer population beginning to experience joint pain associated with age, we think there is great potential for bringing these imaging techniques from the lab to the benefit of patients."
The clinical practice standard is to use conventional MRI imaging to assess the quality of cartilage in patients with joint pain, or known arthritis, which focuses on the morphological integrity of the cartilage. In the lab, however, radiologists, orthopedic surgeons, and rheumatologists working as a team have used advances in MRI technology and biochemical imaging techniques to assess cartilage damaged by osteoarthritis. Damaged cartilage shows distinct changes in the concentration of water and collagen molecules, the micro- and macrostructure of collagen, and the concentrations of particular proteins, glycosoaminoglycans. The findings support the use of these MRI techniques in the evaluation of younger patients with joint pain to identify the beginnings of OA – allowing for earlier treatment to halt the progression of the disease.
"The development and optimization of these innovative MR techniques has opened up a new window into the understanding and possible treatment of arthritis before irreversible structural and morphological changes has occurred," said Michael P. Recht, MD, Louise Marx professor of radiology and chairman of the Department of Radiology.
The full study can be found at http://www.jaaos.org/cgi/content/full/19/7/420. For more information about NYU Langone Medical Center's orthopaedic and rheumatology research, go to http://orthosurgery.med.nyu.edu/research.
About NYU Langone Medical Center
NYU Langone Medical Center, a world-class, patient-centered, integrated, academic medical center, is one on the nation's premier centers for excellence in clinical care, biomedical research and medical education. Located in the heart of Manhattan, NYU Langone is composed of three hospitals – Tisch Hospital, its flagship acute care facility; the Rusk Institute of Rehabilitation Medicine, the world's first university-affiliated facility devoted entirely to rehabilitation medicine; and the Hospital for Joint Diseases, one of only five hospitals in the nation dedicated to orthopaedics and rheumatology – plus the NYU School of Medicine, which since 1841 has trained thousand of physicians and scientists who have helped to shape the course of medical history. The medical center's tri-fold mission to serve, teach and discover is achieved 365 days a year through the seamless integration of a culture devoted to excellence in patient care, education and research. For more information, go to www.NYULMC.org.
Craig Andrews | EurekAlert!
Rutgers researchers develop automated robotic device for faster blood testing
14.06.2018 | Rutgers University
Speech comprehension with a cochlear implant
04.06.2018 | Universität zu Lübeck
Moving into its fourth decade, AchemAsia is setting out for new horizons: The International Expo and Innovation Forum for Sustainable Chemical Production will take place from 21-23 May 2019 in Shanghai, China. With an updated event profile, the eleventh edition focusses on topics that are especially relevant for the Chinese process industry, putting a strong emphasis on sustainability and innovation.
Founded in 1989 as a spin-off of ACHEMA to cater to the needs of China’s then developing industry, AchemAsia has since grown into a platform where the latest...
The BMBF-funded OWICELLS project was successfully completed with a final presentation at the BMW plant in Munich. The presentation demonstrated a Li-Fi communication with a mobile robot, while the robot carried out usual production processes (welding, moving and testing parts) in a 5x5m² production cell. The robust, optical wireless transmission is based on spatial diversity; in other words, data is sent and received simultaneously by several LEDs and several photodiodes. The system can transmit data at more than 100 Mbit/s and five milliseconds latency.
Modern production technologies in the automobile industry must become more flexible in order to fulfil individual customer requirements.
An international team of scientists has discovered a new way to transfer image information through multimodal fibers with almost no distortion - even if the fiber is bent. The results of the study, to which scientist from the Leibniz-Institute of Photonic Technology Jena (Leibniz IPHT) contributed, were published on 6thJune in the highly-cited journal Physical Review Letters.
Endoscopes allow doctors to see into a patient’s body like through a keyhole. Typically, the images are transmitted via a bundle of several hundreds of optical...
Light detection and control lies at the heart of many modern device applications, such as smartphone cameras. Using graphene as a light-sensitive material for...
Water molecules exist in two different forms with almost identical physical properties. For the first time, researchers have succeeded in separating the two forms to show that they can exhibit different chemical reactivities. These results were reported by researchers from the University of Basel and their colleagues in Hamburg in the scientific journal Nature Communications.
From a chemical perspective, water is a molecule in which a single oxygen atom is linked to two hydrogen atoms. It is less well known that water exists in two...
13.06.2018 | Event News
08.06.2018 | Event News
05.06.2018 | Event News
15.06.2018 | Materials Sciences
15.06.2018 | Ecology, The Environment and Conservation
15.06.2018 | Power and Electrical Engineering