Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New disposable biosensor may help physicians determine which patients can safely be fed following surgery

08.08.2014

Invention monitors an important new vital sign

A disposal, plastic listening device that attaches to the abdomen may help doctors definitively determine which post-operative patients should be fed and which should not, an invention that may improve outcomes, decrease healthcare costs and shorten hospital stays, according to a UCLA study.


This image shows the non-invasive acoustic gastrointestinal surveillance biosensor.

Credit: UCLA

Some patients who undergo surgery develop a condition called post-operative ileus (POI), a malfunction of the intestines. The condition causes patients to become ill if they eat too soon, which can lengthen an affected patient's hospital stay by two to three days. Until now, there was no way to monitor for POI other than listening to the belly for short periods with a stethoscope, said study first author Dr. Brennan Spiegel, a professor of medicine at the David Geffen School of Medicine at UCLA and the UCLA Fielding School of Public Health.

If proven successful, the device, a non-invasive acoustic gastrointestinal surveillance biosensor called AbStats, could also be used to help diagnose irritable bowel syndrome and inflammatory bowel disease, in addition to helping obese people learn by the sounds from their gut when they should or shouldn't eat to help them lose weight.

Spiegel and his team worked with researchers at the UCLA Wireless Health Institute at the Henry Samueli School of Engineering and Applied Science to develop the sensor, which resembles a small plastic cap and has a tiny microphone inside to monitor digestion.

"We think what we've invented is a way to monitor a new vital sign, one to go along with heart rate, blood pressure and respiration. This new vital sign, intestinal rate, could prove to be important in diagnosing and treating patients," Spiegel said. "The role of wearable sensors in healthcare has reached mainstream consciousness and has the capacity to transform how we monitor and deliver care. Yet, there are very few biosensors that are supported by any peer-reviewed evidence. This study represents peer-reviewed evidence supporting use of a biosensor, a device born and bred out of UCLA multidisciplinary research."

The study appears in the early online edition of the peer-reviewed Journal of Gastrointestinal Surgery.

In this study, the biosensor was used to listen to sounds emanating from the intestines and was connected to a computer that measured the rate of acoustic events – movement of the intestines - as they occurred. The research team compared intestinal rates of healthy subjects using the device for 60 minutes after a standardized meal to rates recorded in two post-operative groups, patients who were tolerating food and those that had POI.

Using the biosensor, Spiegel and his team could distinguish patients with POI from patients who did not suffer from the condition by the sounds made by their intestines. In the future, doctors may use the biosensor to determine which patients can be fed, making an evidence-based decision instead of just guessing based on less specific information, Spiegel said.

Going forward, Spiegel hopes to be able to determine if the biosensor can be used to identify patients at risk for POI to help doctors make post-operative feeding decisions.

"After surgery, the bowels shut down under stress as the body is focused on keeping the brain, heart and lungs alive," Spiegel said. "We also give patients narcotic medications for pain that can also cause the bowels to freeze up. The way doctors currently monitor for POI is putting a stethoscope on the patient's belly for 15 seconds, briefly listening for sounds of intestinal awakening, and asking about flatulence. It's all very rudimentary and inaccurate. With this new vital sign, the team can now monitor the intestines empirically and make more informed decisions."

When the bowels shut down, they become very quiet, moving only a few times per minute versus the digestion of a healthy person, who generates 10 or more intestinal movements per minute. The movements make a "clicking" noise, and it is that noise the biosensor picks up and sends to a computer for analysis.

William J. Kaiser, a professor of electrical engineering and co-director of the UCLA Wireless Health Institute, said development of the biosensor system has been a primary focus of the institute.

"It has been rewarding and exciting for our entire team. The institute develops wearable biomedical sensor systems to support our physician colleagues and fulfill our mission of advancing healthcare delivery," Kaiser said. "The biosensor system is an important example of this rapid development that has resulted in a low-cost instrument that serves an unmet need for continuous, non-invasive monitoring of the human digestive processes. The potential for this biosensor has been thrilling, since it will serve many applications from monitoring of POI to a wide range of digestive process diagnostic applications. The biosensor can operate in the clinic, at home and at any location on the globe."

Gastrointestinal disorders are highly prevalent in both inpatient and outpatient settings. A recent study commissioned by the National Institutes of Health found that there are more than 70 million ambulatory care visits every year in the U.S. with a gastrointestinal disorder listed as the first diagnosis. That number swelled to more than 100 million visits when gastrointestinal disorders were mentioned anywhere in the diagnosis, the equivalent of nearly 36,000 outpatient visits per 100,000 Americans.

Gastrointestinal disorders also have enormous direct and indirect societal costs, Spiegel said. The total direct cost of care for gastrointestinal disorders is estimated at $100 billion annually. Indirect costs increase that figure to more than $140 billion.

"With the aging of the American population and the rising incidence of obesity, it is certain that the economic impact of gastrointestinal disorders will get increasingly worse over the next decade and beyond," Spiegel said.

Kim Irwin | Eurek Alert!
Further information:
http://www.uclahealth.org/

Further reports about: Gastrointestinal Health UCLA bowels decisions disorders healthy sounds

More articles from Medical Engineering:

nachricht UCLA engineers use deep learning to reconstruct holograms and improve optical microscopy
22.11.2017 | University of California - Los Angeles

nachricht First transcatheter implant for diastolic heart failure successful
16.11.2017 | The Ohio State University Wexner Medical Center

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Underwater acoustic localization of marine mammals and vehicles

23.11.2017 | Information Technology

Enhancing the quantum sensing capabilities of diamond

23.11.2017 | Physics and Astronomy

Meadows beat out shrubs when it comes to storing carbon

23.11.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>