Gamma and neutron imaging offer possible improvements over existing techniques such as X-ray or CT, but their safety is not yet fully understood.
Using computer simulations, imaging the liver and breast with gamma or neutron radiation was found to be safe, delivering levels of radiation on par with conventional medical imaging, according to researchers at Duke Medicine.
This shows simulated 3D dose measurements of the breast showing the dose imparted to the whole body. The dose is shown on a red and yellow color map, where yellow shows maximum dose.
Credit: Duke Medicine
The findings, published in the June issue of the journal Medical Physics, will help researchers to move testing of gamma and neutron imaging into animals and later humans.
Conventional medical imaging tools – including X-ray, ultrasound, CT and MRI – detect disease by finding the anatomy, or shape and size, of the abnormality. When using these tools to screen for cancer, a tumor must be large enough to be detected, and if found, a surgical biopsy is generally required to determine if it is benign or malignant.
Duke researchers are working to develop imaging technologies to detect disease in its earliest stages, much before the tumors grow large enough to be detected using conventional methods. Two imaging techniques they are researching are Neutron Stimulated Emission Computed Tomography and Gamma Stimulated Emission Computed Tomography.
Research has shown that many tumors have an out-of-balance concentration of trace-level elements naturally found in the body, such as aluminum and rubidium. These elements stray from their normal concentration levels at the earliest stages of tumor growth, potentially providing an early signal of disease.
The neutron and gamma imaging methods measure the concentrations of elements in the body, determining molecular properties without the need for a biopsy or injection of contrast media. The goal is for these tests to be able to distinguish between benign and malignant lesions, as well as healthy tissue.
"Gamma and neutron imaging may eventually be able to help us to detect cancer earlier without having to perform an invasive biopsy," said Anuj Kapadia, Ph.D., assistant professor of radiology at Duke University School of Medicine and the study's senior author.
Gamma and neutron imaging may also have applications for patients undergoing cancer treatment. Patients currently wait weeks or months to see if their cancer is responding to a particular treatment and shrinking in size, but gamma and neutron imaging may be able to tell if a treatment is working earlier by detecting molecular changes directly within the tumor.
While improved diagnostic tests would provide clinicians with useful tools, one ongoing question is the safety of gamma and particularly neutron radiation. Upon entering the body, neutrons scatter considerably, with the possibility of reaching several vital organs. Thus, researchers have been concerned about how much radiation is absorbed in the targeted organ versus surrounding tissue. For instance, in a breast scan, how much radiation is delivered unnecessarily to the heart or lungs?
Using detailed computer simulations, Kapadia and his colleagues estimated the radiation dose delivered to the liver and breast using neutron and gamma imaging. They found that the majority of radiation was delivered to organs directly within the radiation beam, and a much lower dose was absorbed by tissue outside of the radiation beam.
In simulated breast scans, the radiation was almost entirely limited to the area of the breast being scanned. The dose to the breast accounted for 96 percent of the radiation in neutron scans and 99 percent in gamma scans. The heart and lungs received less than 1 percent of the radiation dose.
When imaging the liver in simulation, the neutron scan imparted the highest radiation dose to the liver, while in the gamma scan, the stomach wall absorbed the greatest amount of radiation given its location in the direct path of the beam. Further work is needed to reduce and better target gamma radiation doses in liver scans.
"The results show that despite the use of a highly scattering particle such as a neutron, the dose from neutron imaging is on par with other clinical imaging techniques such as X-ray CT," Kapadia said. "Neutron and gamma radiation may become viable imaging alternatives if further testing proves them to be safe and effective."
The researchers will use this information to move their studies into animals, and later, humans.
In addition to Kapadia, authors include Matthew D. Belley and William Paul Segars of Duke. The study was supported by the National Institutes of Health (R01-EB001838, T32-EB007185).
Rachel Harrison | Eurek Alert!
Innovative device allows 3-D imaging of the breast with less radiation
17.06.2016 | DOE/Thomas Jefferson National Accelerator Facility
The vascular bypass revolution
13.06.2016 | Université de Genève
R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.
In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...
High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!
In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...
Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers. "Our goal is to create tissue that can be used to replace large amounts of worn out tissue or design patches," said Ibrahim T. Ozbolat, associate professor of engineering science and mechanics. "Those who have osteoarthritis in their joints suffer a lot. We need a new alternative treatment for this."
Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. It is...
Physicists in Innsbruck have realized the first quantum simulation of lattice gauge theories, building a bridge between high-energy theory and atomic physics. In the journal Nature, Rainer Blatt‘s and Peter Zoller’s research teams describe how they simulated the creation of elementary particle pairs out of the vacuum by using a quantum computer.
Elementary particles are the fundamental buildings blocks of matter, and their properties are described by the Standard Model of particle physics. The...
A year and a half on the outer wall of the International Space Station ISS in altitude of 400 kilometers is a real challenge. Whether a primordial bacterium...
28.06.2016 | Event News
09.06.2016 | Event News
24.05.2016 | Event News
28.06.2016 | Physics and Astronomy
28.06.2016 | Life Sciences
28.06.2016 | Physics and Astronomy