Dynamic contrast-enhanced MRI (DCE-MRI) has emerged in recent years as a useful tool in breast cancer detection and staging. One of its primary limitations is a substantial number of false-positive findings that require biopsies.
"Many benign lesions demonstrate enhancement on DCE-MRI," said Savannah C. Partridge, Ph.D., research associate professor at the University of Washington, Seattle Cancer Care Alliance. "We need another means for differentiating benign lesions from malignancies."
One possible solution is diffusion-weighted imaging (DWI), an MRI technique that calculates the apparent diffusion coefficient (ADC)—a measure of how water moves through tissue.
"DWI has been used mostly in neurological applications, but it's been studied more recently in breast imaging," Dr. Partridge said. "It only adds a couple of minutes to the MRI exam and does not require additional contrast or any extra hardware."
Research has shown that DWI is a promising tool for distinguishing between benign and malignant breast lesions. Normal breast tissue has a high ADC because water moves through it relatively freely, while most cancers have a lower ADC because their cells are more tightly packed and restrict water motion. However, significant overlap exists between the ADC values of non-malignant lesions and breast malignancies, and little is known about the ADC values of specific subtypes of non-malignant lesions.
For the new study, Dr. Partridge and colleagues evaluated the DWI characteristics of non-malignant lesions in 165 women. Based on ADC values above a previously determined diagnostic threshold, DWI successfully characterized 46 percent of non-malignant breast lesions identified as false-positive findings on DCE-MRI as benign.
"We were excited to see the number of false positives that could be reduced through this approach," Dr. Partridge said. "DWI gives us extra microstructural information to distinguish among lesions. We can use ADC values to draw a cutoff above which we might not need to do a biopsy."
The research team is planning a multicenter trial to validate the findings and determine how to best to incorporate ADC measures into clinical breast MRI interpretations.
"We are very motivated to translate this promising technology to a clinically useful breast imaging tool," Dr. Partridge said.
"Nonmalignant Breast Lesions: ADCs of Benign and High-Risk Subtypes Assessed as False-Positive at Dynamic Enhanced MR Imaging." Collaborating with Dr. Partridge were Sana Parsian, M.D., Habib Rahbar, M.D., Kimberly H. Allison, M.D., Wendy D. DeMartini, M.D., Matthew L. Olson, M.S., and Constance D. Lehman, M.D., Ph.D.
Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc. (http://radiology.rsna.org/)
RSNA is an association of more than 50,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)
For patient-friendly information on breast MRI, visit RadiologyInfo.org.
Linda Brooks | EurekAlert!
Penn first in world to treat patient with new radiation technology
22.09.2017 | University of Pennsylvania School of Medicine
Skin patch dissolves 'love handles' in mice
18.09.2017 | Columbia University Medical Center
At the productronica trade fair in Munich this November, the Fraunhofer Institute for Laser Technology ILT will be presenting Laser-Based Tape-Automated Bonding, LaserTAB for short. The experts from Aachen will be demonstrating how new battery cells and power electronics can be micro-welded more efficiently and precisely than ever before thanks to new optics and robot support.
Fraunhofer ILT from Aachen relies on a clever combination of robotics and a laser scanner with new optics as well as process monitoring, which it has developed...
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
25.09.2017 | Power and Electrical Engineering
25.09.2017 | Health and Medicine
25.09.2017 | Physics and Astronomy