Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New MRI technique used to identify early-stage coronary disease

09.10.2012
With the results of a magnetic resonance imaging (MRI) study from the National Institutes of Health (NIH), researchers say they are closer to finding an imaging technique that can identify thickening of the coronary artery wall, an early stage of coronary heart disease (CAD). The study is published online in the journal Radiology.

"Imaging the coronary arteries that supply the heart with blood is extremely difficult because they are very small and constantly in motion," said lead researcher Khaled Z. Abd-Elmoniem, Ph.D., staff scientist in the Biomedical and Metabolic Imaging branch of NIH's National Institute of Diabetes and Digestive and Kidney Diseases. "Obtaining a reliable and accurate image of these vessels is very important because thickening of the vessel wall is an early indicator of atherosclerosis."

CAD occurs when deposits of fat and cholesterol called plaques build up inside coronary arteries (a condition called atherosclerosis), increasing the risk of a heart attack and other coronary events. By identifying the vessel wall thickening that precedes artery narrowing, early intervention is possible.

"We currently have no reliable way to noninvasively image coronary artery disease in its early stages, when the disease can be treated with lifestyle changes and medications to lower cholesterol," Dr. Abd-Elmoniem said.

The researchers used MRI to measure the wall thickness of the coronary arteries in 26 patients with at least one risk factor for CAD and 12 healthy control participants matched to patients by body mass index (BMI). The mean age of the patients, which included 13 men and 13 women, was 48; healthy controls included three men and nine women (mean age 26).

To measure the coronary artery wall thickness in each of the study's participants, the researchers used both a single-frame MRI scan and an MRI technique called time-resolved multi-frame acquisition, in which five continuous images are captured in order to increase the success rate of obtaining an image free of blurring.

Using the time-resolved multi-frame acquisition method, the success rate for obtaining a usable image was 90 percent versus a success rate of 76 percent for the single-frame method.

Use of the time-resolved multi-frame technique also resulted in a greater ability to detect a significant difference between the wall thickness measurements of CAD patients and the healthy participants, as well as a smaller standard deviation, which is indicative of more precise measurements.

"These results suggest that MRI may be used in the future to screen for individuals at risk for coronary artery disease and may be useful for monitoring the effects of therapies," Dr. Abd-Elmoniem said.

"Dr. Abd-Elmoniem is a bright and inventive scientist who first suggested this innovative approach to improving coronary wall imaging," said Roderic Pettigrew, Ph.D., M.D., Director of the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and senior collaborator of the study. "We are delighted that the technique is showing such practical promise."

Dr. Abd-Elmoniem said that unlike blood tests that measure cholesterol and lipids in the blood, which can be indicators of atherosclerosis, the thickness of coronary artery walls is a direct measurement of early-stage CAD. He said additional studies are needed to validate the time-resolved multi-frame MRI technique.

"Coronary Vessel Wall 3-T MR Imaging with Time-Resolved Acquisition of Phase-Sensitive Dual Inversion-Recovery (TRAPD) Technique: Initial Results in Patients with Risk Factors for Coronary Artery Disease." Collaborating with Drs. Abd-Elmoniem and Pettigrew was Ahmed M. Gharib, M.D.

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc.

RSNA is an association of more than 50,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on MRI, visit RadiologyInfo.org.

Linda Brooks | EurekAlert!
Further information:
http://www.rsna.org

More articles from Medical Engineering:

nachricht Visualizing gene expression with MRI
23.12.2016 | California Institute of Technology

nachricht Illuminating cancer: Researchers invent a pH threshold sensor to improve cancer surgery
21.12.2016 | UT Southwestern Medical Center

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Water - as the underlying driver of the Earth’s carbon cycle

17.01.2017 | Earth Sciences

Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

17.01.2017 | Materials Sciences

Smart homes will “LISTEN” to your voice

17.01.2017 | Architecture and Construction

VideoLinks
B2B-VideoLinks
More VideoLinks >>>