The new technique offers better imaging of smaller tumors and may also improve surgical options when fertility-sparing procedures are being considered.
"Small lesions are often difficult to image, but imaging their full extent is important in surgical planning," said study author Nandita deSouza, F.R.C.R., professor and co-director of the Cancer Research UK Clinical Magnetic Resonance Research Group at The Institute of Cancer Research in London, U.K. "By adding this technique to image the diffusion, or movement, of water within tissue, we can improve the accuracy of detecting small tumors."
The American Cancer Society estimates that 11,070 American women will be diagnosed with invasive cervical cancer in 2008. Largely attributable to increased use of the Pap test, cervical cancer death rates declined 74 percent between 1955 and 1992 and continue to decline by nearly 4 percent annually.
"Cervical cancers increasingly are being picked up at an earlier stage," deSouza said. "This procedure causes no more discomfort than a Pap test and the diffusion-weighted imaging itself only takes 84 seconds." The entire procedure takes approximately 15 minutes.
In the 22-month study period, 59 women, ages 24 to 83, were accepted for inclusion into the study and placed into two groups. Group 1 consisted of 20 women awaiting biopsies due to abnormal cervical tissue development at screening and 18 women who had invasive cervical cancer confirmed by biopsy. Group 2 consisted of 21 women in whom it was necessary to evaluate the presence of the invasive disease.
The patients underwent high-resolution MRI with the addition of a ring coil inserted into the vagina and positioned around the cervix. The coil was designed specifically to image the cervix and enabled measurement of diffusion of water within the tissue cells. The researchers found that the diffusion of water was reduced in cancerous tissue compared to normal tissue.
"Measurement of water diffusion enabled us to differentiate cervical cancers from the normal glandular lining of the cervix," deSouza said. "Use of these measurements in conjunction with conventional MRI makes detection of early stage cervical cancer easier. I am hopeful that this technique will be used routinely in the future in patients with suspected small tumors."
Linda Brooks | EurekAlert!
Münster researchers make a fly’s heartbeat visible / Software automatically recognizes pulse
12.03.2018 | Westfälische Wilhelms-Universität Münster
3-D-written model to provide better understanding of cancer spread
05.03.2018 | Purdue University
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
19.03.2018 | Event News
16.03.2018 | Event News
13.03.2018 | Event News
19.03.2018 | Physics and Astronomy
19.03.2018 | Materials Sciences
19.03.2018 | Event News