The new technique offers better imaging of smaller tumors and may also improve surgical options when fertility-sparing procedures are being considered.
"Small lesions are often difficult to image, but imaging their full extent is important in surgical planning," said study author Nandita deSouza, F.R.C.R., professor and co-director of the Cancer Research UK Clinical Magnetic Resonance Research Group at The Institute of Cancer Research in London, U.K. "By adding this technique to image the diffusion, or movement, of water within tissue, we can improve the accuracy of detecting small tumors."
The American Cancer Society estimates that 11,070 American women will be diagnosed with invasive cervical cancer in 2008. Largely attributable to increased use of the Pap test, cervical cancer death rates declined 74 percent between 1955 and 1992 and continue to decline by nearly 4 percent annually.
"Cervical cancers increasingly are being picked up at an earlier stage," deSouza said. "This procedure causes no more discomfort than a Pap test and the diffusion-weighted imaging itself only takes 84 seconds." The entire procedure takes approximately 15 minutes.
In the 22-month study period, 59 women, ages 24 to 83, were accepted for inclusion into the study and placed into two groups. Group 1 consisted of 20 women awaiting biopsies due to abnormal cervical tissue development at screening and 18 women who had invasive cervical cancer confirmed by biopsy. Group 2 consisted of 21 women in whom it was necessary to evaluate the presence of the invasive disease.
The patients underwent high-resolution MRI with the addition of a ring coil inserted into the vagina and positioned around the cervix. The coil was designed specifically to image the cervix and enabled measurement of diffusion of water within the tissue cells. The researchers found that the diffusion of water was reduced in cancerous tissue compared to normal tissue.
"Measurement of water diffusion enabled us to differentiate cervical cancers from the normal glandular lining of the cervix," deSouza said. "Use of these measurements in conjunction with conventional MRI makes detection of early stage cervical cancer easier. I am hopeful that this technique will be used routinely in the future in patients with suspected small tumors."
Linda Brooks | EurekAlert!
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University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...
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