Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

MRI Finds Tumors in Second Breast of Women Diagnosed with Cancer in One Breast

09.03.2010
Postmenopausal women, including those over 70 years old, who have been newly diagnosed with cancer in one breast have higher cancer detection rates when the other breast is scanned for tumors with MRI, compared to premenopausal women, say researchers at the Mayo Clinic campus in Florida.

They found that 3.8 percent of 425 women had breast cancer in the undiagnosed breast that had not been found with a clinical or mammographic examination; all were postmenopausal. In these women, detecting and treating cancer in both breasts at the same time may save costs, patient stress, and the potential toxicity that may come from having to treat cancer later in the second breast once it is discovered, the researchers say in the March/April issue of The Breast Journal.

Of particular interest to the researchers is their finding that patients 70 and older had a higher prevalence of cancer detected in the second breast by MRI than did younger patients in the study. MRI detected a cancer in the second breast in 5.4 percent of 129 elderly women included in the study.

"Our findings are not really surprising because we know that the risk of breast cancer increases as age increases," says the study's lead investigator, Johnny Ray Bernard Jr., M.D., a Radiation Oncologist at Mayo Clinic in Jacksonville. "Elderly women in good health potentially benefit from earlier detection, and we believe that screening of the undiagnosed breast with MRI should be considered in all postmenopausal women diagnosed with a breast cancer."

Since 2003, Mayo Clinic in Jacksonville has offered MRI imaging of both breasts in women with newly diagnosed breast cancer. In this study, Mayo researchers retrospectively reviewed the records of 425 women who underwent bilateral breast MRI between 2003 and 2007. The goal was to determine the prevalence of "contralateral" cancer detected by MRI, but not found by mammogram or clinical breast exams. Contralateral refers to the opposite breast where cancer was not diagnosed.

They concluded that postmenopausal status was the only statistically significant predictor of contralateral cancer detected by MRI. In 72 of the 425 women, MRI detected a suspicious lesion. A follow-up biopsy showed that 16 (22 percent) of the 72 women had contralateral breast cancer (stage 0-1) that had not been detected with typical screening methods. Of the 16 women diagnosed with a contralateral cancer, seven were 70 or older.

The researchers undertook the study, they say, because to their knowledge, no published studies in the medical literature that have examined the use of MRI to screen contralateral breasts in women diagnosed with breast cancer have included an analysis of women 70 and older.

It makes sense to look at women of this age, they say. Studies have shown that MRI of the breast has a higher cancer detection rate than clinical breast examination and mammography alone in women at high risk for developing breast cancer, according to Dr. Bernard. He added that women who have been diagnosed with breast cancer are at 2-to-6 times increased risk for developing a secondary, contralateral breast cancer, compared to women at average risk. "So the combination of older age and a personal breast cancer history possibly makes women aged 70 years or older with newly diagnosed breast cancer at even higher risk for developing a contralateral breast cancer," he says.

Dr. Bernard acknowledges that the routine use of breast MRI in all patients with a history of breast cancer at initial diagnosis is controversial, as is its use in elderly patients. But he says the findings from this study may help clarify the debate because it suggests that postmenopausal patients have the highest prevalence of contralateral breast cancer identified only by MRI, and not by mammogram or physical examination. "This could impact health care costs by limiting screening MRI to those groups likely to have higher detection rates, such as postmenopausal women in our study, and also could reduce costs by having both cancers treated at the same time instead of undergoing potentially toxic and expensive treatments twice — that is, once the contralateral cancer is finally detected by mammogram or physical exam," Dr. Bernard says.

The researchers also say there should be no age cutoff in use of MRI in these breast cancer patients. "We do feel that life span is underestimated in this older age group," he says.

No funding was provided for this study.

About Mayo Clinic
Mayo Clinic is the first and largest integrated, not-for-profit group practice in the world. Doctors from every medical specialty work together to care for patients, joined by common systems and a philosophy of "the needs of the patient come first." More than 3,700 physicians, scientists and researchers, and 50,100 allied health staff work at Mayo Clinic, which has campuses in Rochester, Minn; Jacksonville, Fla; and Scottsdale/Phoenix, Ariz.; and community-based providers in more than 70 locations in southern Minnesota., western Wisconsin and northeast Iowa. These locations treat more than half a million people each year. To obtain the latest news releases from Mayo Clinic, go to www.mayoclinic.org/news. For information about research and education, visit www.mayo.edu. MayoClinic.com (www.mayoclinic.com) is available as a resource for your health stories.

Kevin Punsky | EurekAlert!
Further information:
http://www.mayo.edu

More articles from Medical Engineering:

nachricht Surgery involving ultrasound energy found to treat high blood pressure
24.05.2018 | Queen Mary University of London

nachricht XXL computed tomography: a new dimension in X-ray analysis
17.05.2018 | Fraunhofer-Gesellschaft

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>