Kirsten Müller-Vahl, from Hanover Medical School, led a team of researchers who used normal MRI scanning and the new MTI technique to investigate the brains of 19 Tourette's patients and 20 controls.
They identified alterations in the frontal lobe of the Tourette's group that they suggest may be responsible for the pathology of the syndrome. Müller-Vahl said, "Our in vivo findings, using two sensitive and unbiased techniques, support the hypothesis that alterations in frontostriatal circuitries underlie Tourette's pathology".
The MTI technique used by the researchers has never before been applied to the study of Tourette's. It is a refinement of the nuclear magnetic resonance technique and allows for the detection of changes invisible to conventional MRI scanners. Tissue alterations in comparison to controls were detected in brain areas involved in the selection, programming, initiation, and control of movement. The authors conclude, "We suggest that Tourette's is primarily caused by a dysfunction in prefrontal cortex areas rather than the basal ganglia, as has been previously thought".
Tourette's syndrome is estimated to affect between 1-10 children per 1000 and, although the severity of a person's tics tends to decline with age, as many as 1% of the adult population may have some form of tic disorder. Symptoms include various facial, phonic and other motor tics - the well-known propensity for 'un-voluntary' swearing is in fact relatively uncommon, only affecting about 10% of Tourette's patients.
Graeme Baldwin | EurekAlert!
'Neuron-reading' nanowires could accelerate development of drugs for neurological diseases
12.04.2017 | University of California - San Diego
PET radiotracer design for monitoring targeted immunotherapy
10.04.2017 | Society of Nuclear Medicine
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
20.04.2017 | Event News
18.04.2017 | Event News
03.04.2017 | Event News
24.04.2017 | Physics and Astronomy
24.04.2017 | Materials Sciences
24.04.2017 | Life Sciences