Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Engineers complete first comprehensive mesh-free numerical simulation of skeletal muscle tissue

01.10.2014

Engineers complete first comprehensive mesh-free numerical simulation of skeletal muscle tissue

Engineers at the University of California, San Diego, have completed the first comprehensive numerical simulation of skeletal muscle tissue using a method that uses the pixels in an image as data points for the computer simulation—a method known as mesh-free simulation.


From left: Distribution of maximum stress in the 3D model; and a cross-section

showing maximum stress.

The researchers, led by J.S. Chen, the William Prager Professor of structural engineering at the Jacobs School of Engineering at UC San Diego, presented their findings on the development of this method at the CompIMAGE'14 conference in Pittsburgh this month. Chen also gave a keynote speech about the work.

Chen’s group has now expanded the use of mesh-free simulation methods to investigate aging and disorders impacting muscle functions, such as muscular dystrophy. “Another area of application for this framework would be the simulation of tissue injuries caused by extreme events such as blasts, car crashes and sport collisions”. Chen said. This will require adding the mechanics of tissue damage to the simulation model, including how tissue behaves and functions under high velocity impact.

Traditionally, engineers rely on the reconstruction of the geometry captured by from CT scans or MRI images to create simulation models of biological materials, such as muscle tissue.  The reconstructed 3D geometry is then used to generate a mesh to describe the material’s structure—this is known as the conventional finite element method. This procedure is extremely time consuming and labor intensive.

Using the mesh-free method cuts back on the amount of time for the process of generating the simulation model because researchers don’t have to build a mesh for the structure they’re trying to simulate, said Ramya Rao Basava, the lead Ph.D. student on the study.

For this study, researchers in Chen’s group used Magnetic Resonance and Diffusion Tensor images for the mesh-free simulation. The images were obtained through the Department of Radiology at UC San Diego. The image data acquired was from 10 volunteers between the ages of 20 to 90. The younger subjects were mostly in their 20s and 30s, the older ones mostly in their 80s.

Chen’s research group used the simulation techniques they developed to look at how much force is generated from various muscle systems, and more specifically at how loss of force relates to loss of muscle volume due to aging. They found that the loss of force is greater than the loss of volume, which is consistent with prior physiological studies.

Chen is a leader in the field of computational mechanics, particularly mesh-free methods for structures and materials subjected to large deformation and damages.

Chen’s research group has advanced mesh-free method research to achieve high accuracy and efficiency in simulating a wide range of engineering and scientific problems that are difficult or impossible to simulate via mesh-based methods, for example, fragment-impact modeling for homeland security applications, landslide simulations in natural disaster predictions, manufacturing processes and contact-impact modeling in the automotive industry, multi-scale materials modeling in material science applications and modeling of DNA-protein interaction, among others. Recently, his research group has started venturing into the field of simulation for biological materials such as muscle tissue.

Chen is also the faculty director of UC San Diego’s new Center for Extreme Events Research, which has been established to offer solutions to a wide range of challenges associated with extreme events, such as blasts and landslides, and brings together unique experimental technologies and advances in computational methods. 

Media Contacts

Ioana Patringenaru
Jacobs School of Engineering
Phone: 858-822-0899
ipatrin@ucsd.edu

Ioana Patringenaru | Eurek Alert!
Further information:
http://www.jacobsschool.ucsd.edu/news/news_releases/release.sfe?id=1577

More articles from Medical Engineering:

nachricht UTSA study describes new minimally invasive device to treat cancer and other illnesses
02.12.2016 | University of Texas at San Antonio

nachricht Earlier Alzheimer's diagnosis may be possible with new imaging compound
02.11.2016 | Washington University School of Medicine

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>