Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Early detection of increased thrombosis risk: New antithrombin test by Siemens Healthcare for the European markets

Siemens Healthcare has developed Innovance Antithrombin, a new test for determining congenital and acquired antithrombin deficiency. Insufficient levels of protein in blood can lead to increased thrombophilia.

Reason: Antithrombin ensures balanced blood coagulation by reducing the activity of thrombin and coagulation factor Xa which are responsible for blood coagulation. Innovance Antithrombin detects insufficient antithrombin activity, enabling the early detection of an increased risk of thrombosis in patients.

Innovance Antithrombin by Siemens Healthcare is a new chromogenic test for the automatic quantification of functionally active antithrombin in human citrated plasma. In contrast to antithrombin activity tests based on the inhibition of the coagulation factor thrombin, Innovance Antithrombin determines the activity of the antithrombin protein through the inhibition of coagulation factor Xa. This prevents distortion of the test result if a patient was given specific medication to prevent or treat thromboses, such as hirudin or other thrombin inhibitors.

Innovance Antithrombin can be used with the automatic coagulation measuring devices from Siemens such as BCS and BCS XP as well as Sysmex CA-500, Sysmex CA-1500 and Sysmex CA-7000.

The new test by Siemens is also suitable for diagnosing congenital or acquired antithrombin deficiencies which are known to be linked with an increased risk of thrombosis. Antithrombin deficiencies manifest themselves in reduced activity of the antithrombin protein. Two types of congenital antithrombin deficiencies are distinguished: in case of deficiency type I, the total quantity of existing antithrombin protein is reduced, whereas in case of deficiency type II, the protein concentration is normal, but the protein is defective in respect of its inhibitor function.

Acquired antithrombin deficiency exists if less antithrombin protein is produced or more is spent than usual. This may result, for example, from liver diseases, DIC (disseminated intravascular coagulation), sepsis, acute hemolytic transfusion reaction, nephrotic syndrome or major surgical interventions. The test can also serve for monitoring the substitution therapy with antithrombin concentrates.

The test kit components of Innovance Antithrombin are ready for use and therefore especially fast and easy to use. The test is based on a chromogenic measurement principle. Citrated plasma is mixed with a surplus of coagulation factor Xa. If heparin is present, part of coagulation factor Xa is bonded and deactivated by the antithrombin present in the specimen. Surplus, uninhibited coagulation factor Xa then splits a chromogenic substrate. In this process, coloring is released, the concentration of which is detected with a photometer.

The higher the concentration of the produced coloring, the higher was the quantity of uninhibited coagulation factor Xa and the lower was the concentration of functionally active antithrombin originally present in the plasma specimen.

The Siemens Healthcare Sector is one of the world’s largest healthcare solution providers. The company defines itself as a medical solution provider with core competences and innovative strengths in diagnostic and therapeutic technologies as well as knowledge processing, including information technology and system integration. With its acquisitions in laboratory diagnostics, Siemens Healthcare is the first integrated healthcare company that combines imaging and lab diagnostics, therapy solutions and medical information technology and also supplements these with consultation and services. Siemens Healthcare provides solutions for the entire supply chain under one umbrella – from prevention, early detection and diagnosis to therapy and aftercare. In addition, Siemens Healthcare is the global brand leader for innovative hearing aids. Siemens Healthcare currently has around 49,000 employees worldwide and is represented in more than 130 countries. During fiscal 2008 (ending on September 30), Siemens Healthcare achieved a total sales volume of 11.17 billion euros and incoming orders totaling 11.78 billion euros. The Group earnings amounted to 1.23 billion euros.

Marion Bludszuweit | Siemens Healthcare
Further information:

More articles from Medical Engineering:

nachricht Münster researchers make a fly’s heartbeat visible / Software automatically recognizes pulse
12.03.2018 | Westfälische Wilhelms-Universität Münster

nachricht 3-D-written model to provide better understanding of cancer spread
05.03.2018 | Purdue University

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Mars' oceans formed early, possibly aided by massive volcanic eruptions

Oceans formed before Tharsis and evolved together, shaping climate history of Mars

A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...

Im Focus: Tiny implants for cells are functional in vivo

For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.

In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Virtual reality conference comes to Reutlingen

19.03.2018 | Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

Latest News

Physicists made crystal lattice from polaritons

20.03.2018 | Physics and Astronomy

Mars' oceans formed early, possibly aided by massive volcanic eruptions

20.03.2018 | Physics and Astronomy

Thawing permafrost produces more methane than expected

20.03.2018 | Earth Sciences

Science & Research
Overview of more VideoLinks >>>