The resulting products are expected to dramatically advance diabetes treatment in India, by offering a portable, discreet, quick and easy insulin dosage system for users on the move.
The DuPont components used in the reusable pen (left to right): The gray clip and dose dial (Crastin®), the green thumb pad, black drive shaft and inner housing, green piston rod cap (Zytel®) and white locking sleeve (within inner housing) and clutch tube (both Delrin®).
The insulin pen design is the size of a marker pen and is manufactured entirely from plastic, whereby a number of the key components, required for the accurate dose setting and delivery of the insulin, are moulded from engineering thermoplastics from DuPont. DuPont™ Delrin® acetal homopolymer resin, a common choice for safety components to obtain highest device reliability, is used for the clutch tube and locking sleeve. DuPont™ Zytel® nylon resin has been selected for the drive shaft, inner housing, thumb pad and piston rod cap.
“For the intricate system of ratchets and gears used within the pen’s delivery mechanism, we needed a material such as Delrin® that could deliver excellent dimensional stability in combination with resistance to creep and a certain level of natural lubricity,” explains IDC’s Managing Director, Stephen Knowles. “Moreover, where many mechanical movements must occur in an exact sequence, there are components that need the combination of very high impact strength, elastic modulus and tensile strength. For these we chose Zytel®.”
A further DuPont material, DuPont™ Crastin® PBT polyester resin, is used for the pen’s dose dial and clip. These parts had initially been specified in Zytel®, however testing revealed that the nylon would absorb moisture in the extremely humid conditions prevalent in India, which in turn would have a detrimental effect on dose accuracy. “We quickly needed an alternative material with the same functional properties and that could be used in the same tools,” explains Knowles. “Fortunately, DuPont was able to ship us samples of Crastin® to Thailand for testing within a week, and we found it to be the perfect alternative!” The polyester resin’s visual appeal and suitability for printing were further benefits to be gained from the change of material.
The overall project was coordinated across Europe and Asia by IDC: the production of high-precision tooling was carried out in Taiwan, testing to ISO standards was conducted in Holland, while the Indian moulder, Shaily Engineering Plastics Limited were responsible for production manufacturing. DuPont representatives in each continent were heavily involved in the project’s completion and ultimate success, as Stephen Knowles acknowledges: “The breadth of material offering from a single source, plus the readily available, local technical support were the greatest benefits of working with DuPont. Familiar with their products from previous projects, we knew what to expect in terms of material performance and quality. But when a problem does occur, they had the back-up and resources to solve it quickly!”
The DuPont Engineering Polymers business manufactures and sells Crastin® PBT and Rynite® PET thermoplastic polyester resins, Delrin® acetal resins, Hytrel® thermoplastic polyester elastomers, DuPont™ ETPV engineering thermoplastic vulcanizates, Minlon® mineral reinforced nylon resins, Thermx® PCT polycyclohexylene dimethyl terephthalate, Tynex® filaments, Vespel® parts and shapes, Zenite® LCP liquid crystal polymers, Zytel® nylon resins and Zytel® HTN high-performance polyamides. These products serve global markets in the aerospace, appliance, automotive, consumer, electrical, electronic, healthcare, industrial, sporting goods and many other diversified industries.
DuPont is a science-based products and services company. Founded in 1802, DuPont puts science to work by creating sustainable solutions essential to a better, safer, healthier life for people everywhere. Operating in more than 70 countries, DuPont offers a wide range of innovative products and services for markets including agriculture and food; building and construction; communications; and transportation.
The DuPont Oval, DuPont™, The miracles of science™ Crastin®, Delrin® and Zytel® are registered trademarks or trademarks of E.I. du Pont de Nemours and Company or its affiliates.
Horst Ulrich Reimer | Du Pont
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