Population-based screening with full-field digital mammography (FFDM) is associated with lower recall and biopsy rates than screen film mammography (SFM), suggesting that FFDM may reduce the number of diagnostic workups and biopsies that do not lead to diagnosis of breast cancer, according to a new study published online in the journal Radiology.
Previous population-based studies comparing the accuracy of SFM versus FFDM have reported conflicting results, and reported recall rates—or the rate at which women are called back for additional tests—have varied widely. In addition, past performance evaluations of breast imaging screening technologies do not account for the transition phase of adoption.
For this study, data collected from the Norwegian Breast Cancer Screening Program (NBCSP) was used to compare performance measures and outcomes before, during and after the transition from SFM to FFDM.
"The program invites women age 50 to 69 years to mammographic screening every two years," said Solveig Hofvind, Ph.D., from the Cancer Registry of Norway and Oslo University College, in Oslo, Norway. "We analyzed performance measures in the program as run in a usual setting."
To examine the effect of transition from SFM to FFDM, researchers analyzed the rate of cases, the recall rate, the rate of screen-detected cancer, and the rate of interval cancers.
"The study includes results from women screened with SFM only, with both SFM and FFDM, and with FFDM only. These combinations make us able to compare early performance measures achieved when using digital mammography in a routine setting, in a proper way," Dr. Hofvind said.
A total of 1,837,360 NBCSP screening exams were performed from 1996 through 2010, with 58.8 years being the average age at the time of screening. The overall recall rate was 3.4 percent for SFM and 2.9 percent for FFDM. The biopsy rate was 1.4 percent for SFM and 1.1 percent for FFDM.
Both the rate of invasive screening-detected and interval breast cancer remained stable during the transition from SFM to FFDM and after FFDM was firmly established. The positive predictive value of recalled examinations and of biopsy procedures increased from 19.3 percent and 48.3 percent to 22.7 percent and 57.5 percent, respectively, after adoption of FFDM.
By studying the transition phase of screening modality, researchers discovered FFDM implementation led to lower rates of false positive screening exams and fewer biopsies with benign outcome.
"Mammographic Performance in a Population-based Screening Program: Before, during, and after the Transition from Screen-Film to Full-Field Digital Mammography." Collaborating with Dr. Hofvind were Per Skaane, M.D., Ph.D., Joann G. Elmore, M.D., Ph.D., Sofie Sebuødegård, B.Sc., Solveig Roth Hoff, M.D., Ph.D., and Christoph I. Lee, M.D., MSHS.
Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc.
RSNA is an association of more than 53,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)
For patient-friendly information on mammography, visit RadiologyInfo.org.
Linda Brooks | EurekAlert!
Innovative device allows 3-D imaging of the breast with less radiation
17.06.2016 | DOE/Thomas Jefferson National Accelerator Facility
The vascular bypass revolution
13.06.2016 | Université de Genève
R2D2, a joint project to analyze and development high-TRL processes and technologies for manufacture of flexible organic light-emitting diodes (OLEDs) funded by the German Federal Ministry of Education and Research (BMBF) has been successfully completed.
In contrast to point light sources like LEDs made of inorganic semiconductor crystals, organic light-emitting diodes (OLEDs) are light-emitting surfaces. Their...
High resolution rotational spectroscopy reveals an unprecedented number of conformations of an odorant molecule – a new world record!
In a recent publication in the journal Physical Chemistry Chemical Physics, researchers from the Max Planck Institute for the Structure and Dynamics of Matter...
Strands of cow cartilage substitute for ink in a 3D bioprinting process that may one day create cartilage patches for worn out joints, according to a team of engineers. "Our goal is to create tissue that can be used to replace large amounts of worn out tissue or design patches," said Ibrahim T. Ozbolat, associate professor of engineering science and mechanics. "Those who have osteoarthritis in their joints suffer a lot. We need a new alternative treatment for this."
Cartilage is a good tissue to target for scale-up bioprinting because it is made up of only one cell type and has no blood vessels within the tissue. It is...
Physicists in Innsbruck have realized the first quantum simulation of lattice gauge theories, building a bridge between high-energy theory and atomic physics. In the journal Nature, Rainer Blatt‘s and Peter Zoller’s research teams describe how they simulated the creation of elementary particle pairs out of the vacuum by using a quantum computer.
Elementary particles are the fundamental buildings blocks of matter, and their properties are described by the Standard Model of particle physics. The...
A year and a half on the outer wall of the International Space Station ISS in altitude of 400 kilometers is a real challenge. Whether a primordial bacterium...
09.06.2016 | Event News
24.05.2016 | Event News
20.05.2016 | Event News
28.06.2016 | Physics and Astronomy
28.06.2016 | Earth Sciences
28.06.2016 | Earth Sciences