Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Chest CT helps predict cardiovascular disease risk

27.05.2014

Incidental chest computed tomography (CT) findings can help identify individuals at risk for future heart attacks and other cardiovascular events, according to a new study published online in the journal Radiology.


Here are examples of cardiovascular chest CT findings. A, Ascending thoracic aorta diameter measurement. B, Cardiac diameter measurement. C, Calcifications in the left anterior descending coronary artery and the descending thoracic aorta (arrows). D, Calcifications on the mitral valve (arrow).

Credit: Radiological Society of North America

"In addition to diagnostic purposes, chest CT can be used for the prediction of cardiovascular disease," said Pushpa M. Jairam, M.D., Ph.D., from the University Medical Center Utrecht, in Utrecht, the Netherlands. "With this study, we have taken a new perspective by providing a different approach for cardiovascular disease risk prediction strictly based on information readily available to the radiologist."

Currently, individuals at high risk for cardiovascular events are identified through risk stratification tools based on conventional risk factors, such as age, gender, blood pressure, cholestorol levels, diabetes, smoking status or other factors thought to be related to heart disease. However, a substantial number of cardiovascular events occur in individuals with no conventional risk factors, or in patients with undetected or underdiagnosed risk factors.

... more about:
»CT »Chest »RSNA »Radiological »cardiovascular »conventional

"Extensive literature has clearly documented the uncertainty of prediction models based on conventional risk factors," Dr. Jairam said. "With this study, we address to some extent, the need for a shift in cardiovascular risk assessment from conventional risk factors to direct measures of subclinical atherosclerosis."

Through the use of chest CT, radiologists are routinely confronted with findings that are unsuspected or unrelated to the CT indication, known as incidental findings. Incidental findings indicating early signs of atherosclerosis are quite common and could play a role in a population-based screening approach to identify individuals at high risk for cardiovascular events. However, there is currently no guidance on how to weigh these findings in routine practice.

Dr. Jairam and colleagues set out to develop and validate an imaging-based prediction model to more accurately assess the contribution of incidental findings on chest CT in detecting patients at high risk for cardiovascular disease.

The retrospective study looked at follow-up data from 10,410 patients who underwent diagnostic chest CT for non-cardiovascular indications. During a mean follow-up period of 3.7 years, 1,148 cardiovascular events occurred among these patients.

CT scans from these patients and from a random sampling of 10 percent of the remaining patients in the group were visually graded for several cardiovascular findings. The final prediction model included age, gender, CT indication, left anterior descending coronary artery calcifications, mitral valve calcifications, descending aorta calcifications and cardiac diameter. The model was found to have accurately placed individuals into clinically relevant risk categories.

The results showed that radiologic information may complement standard clinical strategies in cardiovascular risk screening and may improve diagnosis and treatment in eligible patients.

"Our study provides a novel strategy to detect patients at high risk for cardiovascular disease, irrespective of the conventional risk factor status, based on freely available incidental information from a routine diagnostic chest CT," Dr. Jairam said. "The resulting prediction rule may be used to assist clinicians to refer these patients for timely preventive cardiovascular risk management."

Dr. Jairam cautions that a prospective, multicenter trial is needed to validate the impact of these findings.

###

"Incidental Imaging Findings from Routine Chest CT Used to Identify Subjects at High Risk of Future Cardiovascular Events." Collaborating with Dr. Jairam were Martijn J.A. Gondrie, M.D., Ph.D., Diederick E. Grobbee, M.D., Ph.D., Willem P. Th. M. Mali, M.D., Ph.D., Peter C. A. Jacobs, M.D., Ph.D., and Yolanda van der Graaf, M.D., Ph.D.

This report is a part of the PROVIDI study and is funded by the Netherlands Organization for Scientific Research-Medical Sciences (NWO-MW).

Radiology is edited by Herbert Y. Kressel, M.D., Harvard Medical School, Boston, Mass., and owned and published by the Radiological Society of North America, Inc..

RSNA is an association of more than 53,000 radiologists, radiation oncologists, medical physicists and related scientists promoting excellence in patient care and health care delivery through education, research and technologic innovation. The Society is based in Oak Brook, Ill. (RSNA.org)

For patient-friendly information on chest CT, visit RadiologyInfo.org.

Linda Brooks | Eurek Alert!

Further reports about: CT Chest RSNA Radiological cardiovascular conventional

More articles from Medical Engineering:

nachricht Speedy computation enables scientists to reconstruct an animal's development cell by cell
21.07.2014 | Howard Hughes Medical Institute

nachricht Capturing cancer: a powerful new technique for early diagnosis
15.07.2014 | Arizona State University

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Anzeige

Anzeige

Event News

9th European Wood-Based Panel Symposium 2014 – meeting point for the wood-based material branch

24.07.2014 | Event News

“Lens on Life” - Artists and Scientists Explore Cell Divison

08.07.2014 | Event News

First International Conference on Consumer Research | ICCR 2014: Early bird deadline July 31, 2014

08.07.2014 | Event News

 
Latest News

Female bonobos start up early

28.07.2014 | Life Sciences

First national study finds trees saving lives, reducing respiratory problems

28.07.2014 | Health and Medicine

Kidney transplant drug halves the early risk of rejection and allows less toxic treatment

28.07.2014 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>