Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

3D Mammography finds more invasive cancers and reduces unnecessary recalls

25.06.2014

Donna Plecha, M.D., of University Hospitals Case Medical Center co-authored largest 3D study to date of nearly half a million women, published in JAMA

3D Mammography finds significantly more invasive cancers and reduces unnecessary recalls, according to a large, retrospective study published in June 25 issue of the Journal of the American Medical Association (JAMA). The study features data from University Hospitals Case Medical Center Seidman Cancer Center.

The study, the largest of its kind, focused on the impact of 3D mammography at a diverse range of sites across the U.S, looking at nearly half a million mammograms at 13 sites.

Key Findings:

  • 41% increase in invasive cancer detected with 3D mammography
  • 15% decrease in unnecessary recalls for false alarms
  • A 29% increase in the detection of all breast cancers

"This study confirms what we already know: 3D mammography finds more of the invasive, harmful cancers we want found and saves women the anxiety and cost of having additional exams for what turns out to be a false alarm," said the study's co-author Donna Plecha, MD, Director of Breast Imaging at UH Case Medical Center. "We already knew that breast screening saves lives and this study provides us with firm data that 3D mammography is a better test for detecting breast cancer early when it is treatable."

Hologic 3D mammography (breast tomosynthesis) was used exclusively in the study, as they are the only FDA-approved 3D mammography manufacturer. University Hospitals Case Medical Center was involved in the initial research on tomosynthesis and has offered 3D mammography since 2011.

The system combines advanced digital mammography and tomosynthesis-generated images to provide a more detailed, highly focused picture of the breast. These images are then used to produce a series of one-millimeter thick slices that can be viewed as a 3D reconstruction of the breast. Women see little difference between a conventional 2D mammogram and a 3D mammogram. The exam takes just a few seconds longer and the positioning is the same. The real difference is in the information available to the doctor.

The technology gives radiologists the ability to identify and characterize individual breast structures and clearly see features which might be obscured in a traditional 2D mammogram by overlapping normal breast anatomy that may mimic or mask a tumor. Dense tissue and overlapping tissue structures may lead to false positive or false negative results with standard mammography.

Breast cancer is a significant health problem and statistics indicate that one in eight women will develop the disease in her lifetime. The stage at which the cancer is discovered influences a woman's chance of survival and annual mammography after the age of 40 enables physicians to identify the smallest abnormalities. In fact, when breast cancer is detected early and confined to the breast, the five-year survival rate is 97 percent.

"Breast cancers caught in the initial stages by mammography are more likely to be cured and are less likely to require chemotherapy or as extensive surgery," said Dr. Plecha, who is also Assistant Professor at Case Western Reserve University School of Medicine. "This study shows that 3D mammography is a more effective screening tool, and we must make it accessible to all women."

###

The study, led by Dr. Sarah Friedewald at Advocate Lutheran Hospital in Park Ridge, Il, was published in advance of print on the JAMA website: http://jama.jamanetwork.com/journal.aspx .

About University Hospitals

University Hospitals, the second largest employer in Northeast Ohio with 25,000 employees, serves the needs of patients through an integrated network of 12 hospitals, 26 outpatient centers and primary care physician offices in 16 counties. At the core of our $3.5 billion health system is University Hospitals Case Medical Center, one of only 18 hospitals in the country to have been named to U.S. News & World Report's most exclusive rankings list: the Best Hospitals 2013-14 Honor Roll. The primary affiliate of Case Western Reserve University School of Medicine, UH Case Medical Center is home to some of the most prestigious clinical and research centers of excellence in the nation, including cancer, pediatrics, women's health, orthopaedics, radiology, neuroscience, cardiology and cardiovascular surgery, digestive health, transplantation and genetics. Its main campus includes UH Rainbow Babies & Children's Hospital, ranked among the top children's hospitals in the nation; UH MacDonald Women's Hospital, Ohio's only hospital for women; and UH Seidman Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center at Case Western Reserve University. For more information, go to http://www.uhhospitals.org

Alicia Reale | Eurek Alert!

Further reports about: Cancer Medicine Reserve breast difference images invasive mammogram mammography

More articles from Medical Engineering:

nachricht UTSA study describes new minimally invasive device to treat cancer and other illnesses
02.12.2016 | University of Texas at San Antonio

nachricht Earlier Alzheimer's diagnosis may be possible with new imaging compound
02.11.2016 | Washington University School of Medicine

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>