Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

3D Mammography finds more invasive cancers and reduces unnecessary recalls

25.06.2014

Donna Plecha, M.D., of University Hospitals Case Medical Center co-authored largest 3D study to date of nearly half a million women, published in JAMA

3D Mammography finds significantly more invasive cancers and reduces unnecessary recalls, according to a large, retrospective study published in June 25 issue of the Journal of the American Medical Association (JAMA). The study features data from University Hospitals Case Medical Center Seidman Cancer Center.

The study, the largest of its kind, focused on the impact of 3D mammography at a diverse range of sites across the U.S, looking at nearly half a million mammograms at 13 sites.

Key Findings:

  • 41% increase in invasive cancer detected with 3D mammography
  • 15% decrease in unnecessary recalls for false alarms
  • A 29% increase in the detection of all breast cancers

"This study confirms what we already know: 3D mammography finds more of the invasive, harmful cancers we want found and saves women the anxiety and cost of having additional exams for what turns out to be a false alarm," said the study's co-author Donna Plecha, MD, Director of Breast Imaging at UH Case Medical Center. "We already knew that breast screening saves lives and this study provides us with firm data that 3D mammography is a better test for detecting breast cancer early when it is treatable."

Hologic 3D mammography (breast tomosynthesis) was used exclusively in the study, as they are the only FDA-approved 3D mammography manufacturer. University Hospitals Case Medical Center was involved in the initial research on tomosynthesis and has offered 3D mammography since 2011.

The system combines advanced digital mammography and tomosynthesis-generated images to provide a more detailed, highly focused picture of the breast. These images are then used to produce a series of one-millimeter thick slices that can be viewed as a 3D reconstruction of the breast. Women see little difference between a conventional 2D mammogram and a 3D mammogram. The exam takes just a few seconds longer and the positioning is the same. The real difference is in the information available to the doctor.

The technology gives radiologists the ability to identify and characterize individual breast structures and clearly see features which might be obscured in a traditional 2D mammogram by overlapping normal breast anatomy that may mimic or mask a tumor. Dense tissue and overlapping tissue structures may lead to false positive or false negative results with standard mammography.

Breast cancer is a significant health problem and statistics indicate that one in eight women will develop the disease in her lifetime. The stage at which the cancer is discovered influences a woman's chance of survival and annual mammography after the age of 40 enables physicians to identify the smallest abnormalities. In fact, when breast cancer is detected early and confined to the breast, the five-year survival rate is 97 percent.

"Breast cancers caught in the initial stages by mammography are more likely to be cured and are less likely to require chemotherapy or as extensive surgery," said Dr. Plecha, who is also Assistant Professor at Case Western Reserve University School of Medicine. "This study shows that 3D mammography is a more effective screening tool, and we must make it accessible to all women."

###

The study, led by Dr. Sarah Friedewald at Advocate Lutheran Hospital in Park Ridge, Il, was published in advance of print on the JAMA website: http://jama.jamanetwork.com/journal.aspx .

About University Hospitals

University Hospitals, the second largest employer in Northeast Ohio with 25,000 employees, serves the needs of patients through an integrated network of 12 hospitals, 26 outpatient centers and primary care physician offices in 16 counties. At the core of our $3.5 billion health system is University Hospitals Case Medical Center, one of only 18 hospitals in the country to have been named to U.S. News & World Report's most exclusive rankings list: the Best Hospitals 2013-14 Honor Roll. The primary affiliate of Case Western Reserve University School of Medicine, UH Case Medical Center is home to some of the most prestigious clinical and research centers of excellence in the nation, including cancer, pediatrics, women's health, orthopaedics, radiology, neuroscience, cardiology and cardiovascular surgery, digestive health, transplantation and genetics. Its main campus includes UH Rainbow Babies & Children's Hospital, ranked among the top children's hospitals in the nation; UH MacDonald Women's Hospital, Ohio's only hospital for women; and UH Seidman Cancer Center, part of the NCI-designated Case Comprehensive Cancer Center at Case Western Reserve University. For more information, go to http://www.uhhospitals.org

Alicia Reale | Eurek Alert!

Further reports about: Cancer Medicine Reserve breast difference images invasive mammogram mammography

More articles from Medical Engineering:

nachricht Biocompatible 3-D tracking system has potential to improve robot-assisted surgery
17.02.2017 | Children's National Health System

nachricht Real-time MRI analysis powered by supercomputers
17.02.2017 | University of Texas at Austin, Texas Advanced Computing Center

All articles from Medical Engineering >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Multicrystalline Silicon Solar Cell with 21.9 % Efficiency: Fraunhofer ISE Again Holds World Record

20.02.2017 | Power and Electrical Engineering

Biocompatible 3-D tracking system has potential to improve robot-assisted surgery

17.02.2017 | Medical Engineering

Real-time MRI analysis powered by supercomputers

17.02.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>