Stimuli-responsive or ‘smart’ polymeric nanofibers have attracted increasing attention. The nanoscale structures give rise to high sensitivity to stimuli while they can also be manipulated easily as macroscopic materials.
Now researchers at the University of Tsukuba and the National Institute of Materials Science in Japan have demonstrated how they can be used to host magnetic nanoparticles to exploit hyperthermal effects for treating cancer while avoiding the usual side-effects. The incorporation of doxorubicin in the nanofibers as well allows controlled release of the anticancer drug as an additional mechanism for killing cancer cells.
Magnetic nanoparticles can kill cancer cells through the heat generated by induction when subjected to an alternating magnetic field. Such hyperthermal treatments have also been shown to improve the efficacy of anticancer drugs. However the nanoparticles can also lead to impaired mitochondrial function, inflammation, and DNA damage. Incorporating the nanoparticles into nanofibers may provide a solution.
Young-Jin Kim , Mitsuhiro Ebara , and Takao Aoyagi electrspun the fibers from a solution of the polymer poly(NIPAAm- co -HMAAm) mixed with a solution of magnetic nanoparticles and doxorubicin. The heating caused by the nanoparticles when switching on an alternating magnetic field caused hyperthermal effects, as well as reversible deswelling and deformation of the fibers, which released the drug molecules. Investigations in vitro and in cell lines demonstrated effective killing of cancer cells, which was greatly reduced for hyperthermal treatments alone in the absence of doxorubicin.
“The doxorubicin/magnetic-nanoparticles nanofi ber induced the apoptosis of cancer cells due to a synergistic effect of chemotherapy and hyperthermia,” say the authors. The work demonstrates how smart nanofibers have potential for use as a manipulative material that combines hyperthermia and drug release treatments that can be controlled with the simple switching on or off of an alternating magnetic field.
International Center for Materials Nanoarchitectonics(WPI-MANA)
1-1 Namiki, Tsukuba-shi Ibaraki, 305-0044 Japan
Email: Jonathan.Hillnims.go.jp and ARIGA.Katsuhikonims.go.jp
A smart hyperthermia nanofi ber with switchable drug release for inducing cancer apoptosis Young-Jin Kim1,2, Mitsuhiro Ebara1 , and Takao Aoyagi1,2 *,2013 Adv. Funct. Mater. doi: 10.1002/adfm.201300746 .
1. Materials and Science Engineering Graduate School of Pure and Applied Science University of Tsukuba 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8577, Japan
2. Biomaterials Unit International Center for Materials Nanoarchitectonics (WPI-MANA) National Institute for Materials Science (NIMS) 1-1 Namiki, Tsukuba, Ibaraki 305-0044, Japan
*Corresponding author: AOYAGI.Takao@nims.go.jp
Adarsh Sandhu | Source: Research asia research news
Further information: www.nims.go.jp/mana/
More articles from Materials Sciences:
New optimized coatings for implants reduce risk of infection
19.12.2013 | Aalto University, Finland
Crystal film growth: nanosheets extend epitaxial growth applications
19.12.2013 | International Center for Materials Nanoarchitectonics (MANA)
Swimming microengines made from platinum and iron are highly efficient in removing organic pollutants from water using hydrogen peroxide.
Researchers from the Max Planck Institute for Intelligent Systems in Stuttgart have developed a new method for the active degradation of organic pollutants in solution by using swimming microengines.
The mobile microcleaners consist of an outer iron and an inner platinum layer, thereby combining two functionalities. Hydrogen peroxide, which must be ...
A 12-year study of massive stars has reaffirmed that our Galaxy has four spiral arms, following years of debate sparked by images taken by NASA's Spitzer Space Telescope that only showed two arms.
The new research, which is published online today [17 December] in the Monthly Notices of the Royal Astronomical Society, is part of the RMS Survey, which was launched by academics at the University of Leeds.
Astronomers cannot see what our Galaxy, which is called the Milky Way, looks like because we ...
In collaboration with the University of Basel, an international team of researchers has observed a strong energy loss caused by frictional effects in the vicinity of charge density waves.
This may have practical significance in the control of nanoscale friction. The results have been published in the scientific journal Nature Materials.
Friction is often seen as an adverse phenomenon that leads to wear and causes energy loss. Conversely, however, too little friction can be a disadvantage as well – ...
A new type of transistor that could make possible fast and low-power computing devices for energy-constrained applications such as smart sensor networks, implantable medical electronics and ultra-mobile computing is feasible, according to Penn State researchers.
Called a near broken-gap tunnel field effect transistor (TFET), the new device uses the quantum mechanical tunneling of electrons through an ultrathin energy barrier to provide high current at low voltage.
Penn State, the National Institute of Standards and Technology and IQE, a specialty wafer manufacturer, jointly presented their findings at ...
The team of Johannes Zuber at the IMP in Vienna, Austria, managed to overcome remaining key limitations of RNA interference (RNAi) - a unique method to specifically shut off genes.
By using an optimized design, the scientists were able to inhibit genes with greatly enhanced efficiency and accuracy. The new method facilitates the search for drug targets and improves the interpretation of experimental results.
The IMP will make this „RNAi toolkit“ available to researchers. Results of the study are published in ...
19.12.2013 | Life Sciences
19.12.2013 | Health and Medicine
19.12.2013 | Materials Sciences
19.12.2013 | Event News
11.12.2013 | Event News
10.12.2013 | Event News