The new patch can quicken drug delivery time while cutting waste, and can likely minimize side-effects in some cases, notable in vaccinations and cancer therapy.
News of the delivery technology was published in a recent issue of the scientific journal, Advanced Materials.
Leading development of the flexible patch was Lissett Bickford, now an assistant professor and researcher of biomedical engineering and the mechanical engineering, both part of the Virginia Tech College of Engineering. Work on the technology was completed while Bickford was a post-doctoral research associate at the University of North Carolina Chapel Hill.
Microneedle patch technology used on the skin has existed for several years, each patch containing an array of hundreds of micron-sized needles that pierce the skin and dissolve, delivering embedded therapeutics. However, because of their rigid chemical makeup, the patches proved difficult in fully piercing into the skin, creating a waste of drug material and a slowed delivery time. Additionally, the patches also have been difficult to produce in bulk; typical fabrication procedures have required centrifugation.
Bickford, with her research team, including Chapel Hill graduate student Katherine A. Moga, were able to develop a new flexible microneedle patch that forms to the skin directly – think a regular household bandage – and then fully pierces the skin and dissolves. Bickford said the softer, more malleable and water-soluble material also allows for more precise control over the shape, size, and composition of the patch, with little to no waste.
The nanoparticle, micro-molding patch is based on Particle Replication In Non-wetting Templates (PRINT for short) technology, developed by University of North Carolina researcher and professor Joseph DeSimone. Unlike other methods for making these patches, the new technology allows for quicker and greater wide-scale production, reducing related costs.
Research and work on the new patch was funded by the National Institutes of Health and Chapel Hill's University Cancer Research Fund. Advanced Materials wrote of the breakthrough in its July issue.
Bickford earned her bachelor's degree in mechanical engineering from Texas A&M University in 1998, followed by a master's degree in biomedical engineering from The University of Texas Austin inn 2001; and a doctoral degree in bioengineering from Rice University in 2010.
At Virginia Tech, she is director and principal investigator of the Translational Oncology & Nano/Pharmacoengineering Laboratory where she focuses on the development of cost-effective tools for cancer diagnosis and treatment.
Steven Mackay | Source: EurekAlert!
Further information: www.vt.edu
Further Reports about: Advanced Investigator Grant > Advanced Materials > biomedical engineering > Drug Delivery > Ferchau Engineering > flexible microneedle patch > medical engineering > regular household bandage
More articles from Materials Sciences:
Berkeley Lab Researchers Create a Nonlinear Light-generating Zero-Index MetaMaterial
06.12.2013 | DOE/Lawrence Berkeley National Laboratory
Accelerated corrosion testing of silver provides clues about performance in atmospheric conditions
04.12.2013 | NACE International
International team of scientists develops new feedback method for optimizing the laser pulse shapes used in the control of chemical reactions
In many ways, traditional chemical synthesis is similar to cooking. To alter the final product, you can change the ingredients or their ratio, change the method of mixing ingredients, or change the temperature or pressure of the environment of the ingredients.
Like an accomplished chef, chemists have become very skilled ...
A genetic defect protects mice from infection with influenza viruses
A new study published in the scientific journal PLOS Pathogens points out that mice lacking a protein called Tmprss2 are no longer affected by certain flu viruses.
The discovery was made by researchers from the Helmholtz Centre for Infection Research (HZI) in Braunschweig in collaboration with colleagues from Göttingen and ...
The Light: Global study gets underway with online user survey
Light has a fundamental impact on our sense of well-being and performance. In cooperation with Zumtobel, a supplier of lighting solutions, Fraunhofer IAO has launched a global user survey of lighting quality in offices. The objective is to identify the best lighting conditions for a variety of spaces and lighting ...
Quantum entanglement, a perplexing phenomenon of quantum mechanics that Albert Einstein once referred to as “spooky action at a distance,” could be even spookier than Einstein perceived.
Physicists at the University of Washington and Stony Brook University in New York believe the phenomenon might be intrinsically linked with wormholes, hypothetical features of space-time that in popular science fiction can provide a much-faster-than-light shortcut from one part of the universe to another.
But here’s the catch: One couldn’t actually ...
A star is formed when a large cloud of gas and dust condenses and eventually becomes so dense that it collapses into a ball of gas, where the pressure heats the matter, creating a glowing gas ball – a star is born.
New research from the Niels Bohr Institute, among others, shows that a young, newly formed star in the Milky Way had such an explosive growth, that it was initially about 100 times brighter than it is now. The results are published in the scientific journal, Astrophysical Journal Letters.
The young ...
06.12.2013 | Materials Sciences
06.12.2013 | Life Sciences
06.12.2013 | Life Sciences
05.12.2013 | Event News
04.12.2013 | Event News
12.11.2013 | Event News