A polymer inspired by the lipids in cell membranes is proving an invaluable biomaterial. Like the cell membrane, the polymer 2-methacryloyloxyethyl phosphorylcholine (MPC) can provide a surface for biological reactions to take place, but it can also suppress unfavourable processes.
In their recently published review article, Yasuhiko Iwasaki at Kansai University and Kazuhiko Ishihara at the University of Tokyo in Japan describe how developments in synthesis techniques by showing that the 2-methacryloyloxyethyl phosphorylcholine (MPC) have liberated the polymer’s potential for a huge range of medical and biological applications.
In fact the polymers were already attracting interest in the early 1970s. However until more facile synthesis techniques were developed investigations were limited and the polymer was little understood. By 1999 MPC polymers were being produced on an industrial scale, allowing more substantial studies. MPC is easily polymerized in a range of architectures. The chemical can suppress reactions such as protein adsorption and cell adhesion and has a high and readily adjustable solubility in water. These versatile properties lend MPC polymers to a range of applications.
The authors also describe methods for generating the polymer for effective use in non-fouling coatings. Formed into poly(MPC) brush structures with specified chain architectures, they can also be used as surfaces for controlling cell functions. In addition, the researchers explain how surface modifications with MPC polymers are effective in improving blood compatibility. The polymers can suppress protein adsorption, platelet adhesion, and platelet activation at blood-contacting surfaces and they can also be solute permeable. As such they are well suited for coating cardiovascular applications such as stents, cardiopulmonary bypasses, and ventricular assist devices.
Based on the fact that “MPC and various kinds of MPC polymers are now available commercially worldwide, and many medical devices treated with MPC polymers are used in clinics,” they underline how far research into applications of MPC has advanced, and indicate how many possibilities remain for exploiting the chemical further.
Mikiko Tanifuji, National Institute for Materials Science, Tsukuba, Japan
Yasuhiko Iwasaki (1) and Kazuhiko Ishihara (2) Cell membrane-inspired phospholipid polymers for developing medical devices with excellent biointerfaces, Science and Technology of Advanced Materials Vol. 13 (2012) p. 064101 (doi:10.1088/1468-6996/13/6/064101).
1. Department of Chemistry and Materials Engineering, Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35 Yamate-cho, Suita-shi, Osaka 564-8680, Japan
*E-mail address: email@example.com
2. Department of Materials Engineering, School of Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan
*E-mail address: firstname.lastname@example.org
Mikiko Tanifuji | Source: Research asia research news
Further information: www.nims.go.jp
Further Reports about: 2-methacryloyloxyethyl > Advanced Investigator Grant > Biopolymer > cell membrane > CHEMISTRY > Ferchau Engineering > information technology > Materials Engineering > Materials Science > medical devices > MPC
More articles from Materials Sciences:
A new material for solar panels could make them cheaper, more efficient
12.12.2013 | DOE/Argonne National Laboratory
Pioneering Path to Electrical Conductivity in ‘Tinker Toy’ Materials to Appear in Science
11.12.2013 | Sandia National Laboratories
A unique solar panel design made with a new ceramic material points the way to potentially providing sustainable power cheaper, more efficiently, and requiring less manufacturing time.
It also reaches a four-decade-old goal of discovering a bulk photovoltaic material that can harness energy from visible and infrared light, not just ultraviolet light.
Scaling up this new design from its tablet-size prototype to a full-size solar panel would be a large step toward making solar power affordable compared with ...
Atlantische Flohkrebse pflanzen sich jetzt auch in arktischen Gewässern fort
Biologen des Alfred-Wegener-Institutes, Helmholtz-Zentrum für Polar- und Meeresforschung (AWI), haben zum ersten Mal nachgewiesen, dass sich in den arktischen Gewässern westlich Spitzbergens auch Flohkrebse aus dem wärmeren Atlantik fortpflanzen.
Diese überraschende Entdeckung deute auf einen möglichen Wandel der arktischen Zooplankton-Gemeinschaft hin, berichten die Wissenschaftler und Wissenschaftlerinnen in der Fachzeitschrift Marine Ecology ...
The molecular architecture of three key proteins and their complexes reveals how plants fine-tune their immune response to pathogens
Plants rarely get sick in their natural environment. When the threat of infection arises, a quick decision is made about the necessary countermeasures. The course is set by a protein which forms complexes with its partner proteins for this purpose.
Jane Parker from the Max Planck Institute for Plant Breeding ...
Researchers studying speciation of butterfly orchids on the Azores have been startled to discover that the answer to a long-debated question "Do the islands support one species or two species?" is actually "three species".
Hochstetter's Butterfly-orchid, newly recognized following application of a battery of scientific techniques and reveling in a complex taxonomic history worthy of Sherlock Holmes, is arguably Europe's rarest orchid species. Under threat in its mountain-top retreat, the orchid urgently requires conservation recognition.
A lavishly illustrated publication, titled "Systematic revision of Platanthera in ...
Researchers from Brown University and the University of Hawaii have found some mineralogical surprises in the Moon's largest impact crater.
Data from the Moon Mineralogy Mapper that flew aboard India's Chandrayaan-1 lunar orbiter shows a diverse mineralogy in the subsurface of the giant South Pole Aitken basin.
The differing mineral signatures could be reflective of the minerals dredged up at the time of the giant impact 4 billion years ago, ...
12.12.2013 | Life Sciences
12.12.2013 | Earth Sciences
12.12.2013 | Studies and Analyses
11.12.2013 | Event News
10.12.2013 | Event News
05.12.2013 | Event News