Forum for Science, Industry and Business
Sponsored by:     Siemens  n-tv 
Search our Site:

Topic (optional):

 

Home Reports Life Sciences Content

Asthma -- obesity connection

next article
17.07.2006

A new asthma gene provides an unexpected link between asthma and obesity according to a research team at Sydney's Garvan Institute, who are also part of the Cooperative Research Centre for Asthma and Airways.

 

Bennett Shum and colleagues have found that a fatty acid binding protein called aP2, which is already known for its role in diabetes and obesity, is also present in the lung where it is crucial in controlling inflammation in asthma.


About one in ten adults and one in six children in Australia now suffer from asthma. Its incidence in Western countries increased markedly over the last 20 years and has purportedly been linked to the rise in obesity.

"There's up to three times the risk of being asthmatic if you are obese: the more obese, the greater the risk. We know that obese asthmatics who lose weight have large improvements in their asthma," says asthma project leader Dr Michael Rolph.

Various triggers such as dust mites and pollen bring on asthma attacks, which are characterized by inflammation of the airways, a tightening of the surrounding muscles, and excess mucus production.

The scientists used a technique called gene profiling to discover novel genes that regulate airway inflammation and found very high levels of aP2 in human lung cells that had been tricked into thinking they were undergoing an asthma attack.

"We were really surprised to find aP2 in the lung", said Shum. "So, we then looked at what would happen when we removed this gene in mouse models: mice without aP2 are protected from asthma attacks".

"These findings suggest that blocking aP2 function is a novel approach for asthma treatment and other inflammatory lung diseases," he added.

Dr. Branwen Morgan | Source: EurekAlert!
Further information: www.garvan.org.au
www.researchaustralia.com.au/

next article

More articles from Life Sciences:

nachricht First reconstitution of an epidermis from human embryonic stem cells
23.11.2009 | INSERM (Institut national de la santé et de la recherche médicale)

nachricht Causative gene of a rare disorder discovered by sequencing only protein-coding regions of genome
23.11.2009 | University of Washington

All articles from Life Sciences >>>

B2B Search

Product / Service
Company / Organisation

Latest News

UCSB physicists move 1 step closer to quantum computing

23.11.2009 | Physics and Astronomy

Fat around the middle increases the risk of dementia

23.11.2009 | Studies and Analyses

New discovery about the formation of new brain cells

23.11.2009 | Health and Medicine

VideoLinks

Event News

Multidisciplinary meeting on Urological Cancers aims to benefit cancer patients

20.11.2009 | Event News

'Golden Age' for clinical psychology in Northern Ireland

20.11.2009 | Event News

New Perspectives in Marine Anti-Fouling Research

11.11.2009 | Event News