Forum for Science, Industry and Business
Sponsored by:     Siemens  n-tv 
Search our Site:

Topic (optional):

 

Home Reports Life Sciences Content

Could schizophrenia arise from a single defect?

next article
17.02.2005

 


Researchers have long puzzled over the apparently multiple causes of complex developmental disorders such as schizophrenia. Individuals seem to be predisposed to the disease by a tragic, mysterious combination of genetics, prenatal trauma, viral infection, and early experience. And its array of symptoms--including hallucinations, delusions, paranoia, and antisocial behavior--has defied simple explanation.

In experiments with rats, however, researchers led by led by Gerard J.M. Martens of the Nijmegen Center for Molecular Life Sciences (NCMLS) have demonstrated that such seemingly diverse combinations of symptoms can arise from a subtle imbalance in the activity of a single gene whose protein plays a key role in neural development.


The researchers studied the genetic differences between rats bred to be either resistant or susceptible to the drug apomorphine. A long history of studies has revealed that apomorphine-susceptible rats show many behavioral and biochemical differences from normal rats. What’s more, the tendency to develop these differences depends on their exposure to stress in early life.

To search for genetic differences between the two types of rats, the researchers used microarrays, or so-called "gene chips," to analyze the activity of thousands of genes in the rats’ brains. To their surprise, they discovered only a single genetic difference between the two groups of rats. The levels of activity of a gene called Aph-1b tended to be lower in the susceptible rats than in the non-susceptible rats. Importantly, this gene produces a protein that is a component of an enzyme called g-secretase, which plays a role in regulating many processes in the developing brain. The researchers found that, as a result of this lower level of Aph-1b protein, g-secretase showed reduced activity in the brains of the susceptible rats.

What’s more, when the researchers tested various behaviors of "sublines" of rats with different levels of Aph-1b, they found that their behaviors correlated with those levels--termed a "gene dosage effect."

"Thus, a subtle imbalance in the expression of a single gene product that is involved in a wide variety of developmental signaling pathways may well constitute the molecular basis of a complex phenotype that is generally believed to have a multifactorial background," concluded the scientists.

Heidi Hardman | Source: EurekAlert!
Further information: www.cell.com

next article

More articles from Life Sciences:

nachricht Scientists Unravel Evolution of Highly Toxic Box Jellyfish
20.11.2009 | NOAA Fisheries Northeast Fisheries Science Center

nachricht Texas A&M Researchers Examine How Viruses Destroy Bacteria
20.11.2009 | Texas A&M University

All articles from Life Sciences >>>

B2B Search

Product / Service
Company / Organisation

Latest News

Scientists Unravel Evolution of Highly Toxic Box Jellyfish

20.11.2009 | Life Sciences

When good companies do bad things: Examining illegal corporate behavior

20.11.2009 | Business and Finance

UCR plant scientist's research spawns new discoveries showing how crops survive drought

20.11.2009 | Agricultural and Forestry Science

VideoLinks

Event News

Multidisciplinary meeting on Urological Cancers aims to benefit cancer patients

20.11.2009 | Event News

'Golden Age' for clinical psychology in Northern Ireland

20.11.2009 | Event News

New Perspectives in Marine Anti-Fouling Research

11.11.2009 | Event News