A group of Canadian and European researchers have unlocked the mystery of a gene with the potential to both regulate and block ovulation. The new study – a collaboration between the Université de Montréal in Canada and the Institut de génetique et biologie moléculaire et cellulaire of the Université de Louis Pasteur, Strasbourg, France – is published in the latest issue of the journal Genes & Development.
"Our findings demonstrate that the Lrh1 gene is essential in regulating ovulation," said Bruce D. Murphy, director the Animal Research Centre at the Faculty of Veterinary Medicine and an adjunct professor of and obstetrics and gynaecology at the Faculty of Medicine of the Université de Montréal. "Until this point, the role of Lrh1 in female fertility was unclear, but we have found the gene regulates multiple mechanisms of ovulation and may affect fertilization."
To reach their conclusions, the research team developed a new type of genetically modified mouse whose Lrh1 gene was selectively blocked in the ovary. They found that deletion of the Lrh1 gene effectively stopped ovulation. "This discovery means we can envision new contraceptives that selectively stop ovulation," said Dr. Murphy. "If created, these new contraceptives would be more effective and produce less side-effects than current steroid-based forms of birth control."
What's more, the findings could lead to the development of pharmaceuticals that activate the Lrh1 gene, which may prove critical in giving infertile couples hope in producing children. "This is an important development, since 15 percent of couples are infertile," said Dr. Murphy. "The widespread role of this gene in the ovary indicates that it may be targeted to stimulate ovulation and, eventually, conception."
Sylvain-Jacques Desjardins | Source: EurekAlert!
Further information: www.umontreal.ca
www.medvet.umontreal.ca
More articles from Life Sciences:
Scientists Unravel Evolution of Highly Toxic Box Jellyfish
20.11.2009 | NOAA Fisheries Northeast Fisheries Science Center
Texas A&M Researchers Examine How Viruses Destroy Bacteria
20.11.2009 | Texas A&M University
Scientists Unravel Evolution of Highly Toxic Box Jellyfish
20.11.2009 | Life Sciences
When good companies do bad things: Examining illegal corporate behavior
20.11.2009 | Business and Finance
UCR plant scientist's research spawns new discoveries showing how crops survive drought
20.11.2009 | Agricultural and Forestry Science
Multidisciplinary meeting on Urological Cancers aims to benefit cancer patients
20.11.2009 | Event News
'Golden Age' for clinical psychology in Northern Ireland
20.11.2009 | Event News
New Perspectives in Marine Anti-Fouling Research
11.11.2009 | Event News