This finding, the first of its kind and led by UC’s Bruce Yacyshyn, MD, is being presented via podium presentation by staff from Walter Reed National Military Medical Center at Digestive Disease Week 2013, being held May 18-21 in Orlando, Fla.
The DoDSR is a biological repository operated by the U.S. Department of Defense and contains over 50 million human serum specimens, collected primarily from applicants to and members of the U.S. uniformed services.
"With collaborators from Walter Reed, we were able to identify all of the active duty service men and women who developed IBD and then used the repository to go back and look at various biomarkers to see what each person had in common,” says Yacyshyn, a professor of medicine at the UC College of Medicine and UC Health gastroenterologist.
IBD is a group of inflammatory conditions of the colon and small intestine. The main types of IBD are Crohn's disease and ulcerative colitis; inflammatory bowel diseases are considered autoimmune diseases in which the body's own immune system attacks elements of the digestive system.
In this study, researchers used the repository to identify 50 cases of Crohn’s disease and 50 cases of ulcerative colitis. They analyzed proteins from three samples per case—two taken before and one after diagnosis—using a statistical analysis format.
Certain proteins were found in elevated levels in samples from patients who developed IBD.
"The selection of proteins we chose to analyze was based on a prior study conducted at UC,” Yacyshyn says. "Although the presence of proteins in those who develop Crohn’s disease varies from those present in ulcerative colitis patients, we were able to show that there were elevated levels of certain proteins in patients who developed IBD.”
"Future large validation studies are needed to confirm the presence of biomarkers to guide in diagnosis, prevention and management of these patients,” he adds.
Yacyshyn and his collaborators in the division of digestive diseases and at Cincinnati Children’s Hospital Medical Center are hoping to study this further in a pediatric population and have requested funding from the Crohn’s and Colitis Foundation.
"This could change the way we currently screen for and treat IBD, which could improve prevention strategies, patient outcomes and their overall quality of life,” he says.
This study was investigator-initiated.
Katie Pence | Source: EurekAlert!
Further information: www.uc.edu
More articles from Life Sciences:
Estrogen: Not just produced by the ovaries
05.12.2013 | University of Wisconsin-Madison
Iranian biodiversity was underestimated, several new candidate species found
05.12.2013 | Stiftung Zoologisches Forschungsmuseum Alexander Koenig, Leibniz-Institut für Biodiversität der Tiere
The Light: Global study gets underway with online user survey
Light has a fundamental impact on our sense of well-being and performance. In cooperation with Zumtobel, a supplier of lighting solutions, Fraunhofer IAO has launched a global user survey of lighting quality in offices. The objective is to identify the best lighting conditions for a variety of spaces and lighting ...
Quantum entanglement, a perplexing phenomenon of quantum mechanics that Albert Einstein once referred to as “spooky action at a distance,” could be even spookier than Einstein perceived.
Physicists at the University of Washington and Stony Brook University in New York believe the phenomenon might be intrinsically linked with wormholes, hypothetical features of space-time that in popular science fiction can provide a much-faster-than-light shortcut from one part of the universe to another.
But here’s the catch: One couldn’t actually ...
A star is formed when a large cloud of gas and dust condenses and eventually becomes so dense that it collapses into a ball of gas, where the pressure heats the matter, creating a glowing gas ball – a star is born.
New research from the Niels Bohr Institute, among others, shows that a young, newly formed star in the Milky Way had such an explosive growth, that it was initially about 100 times brighter than it is now. The results are published in the scientific journal, Astrophysical Journal Letters.
The young ...
EPFL scientists have shown how to achieve a dramatic increase in the capacity of optical fibers; Their simple, innovative solution reduces the amount of space required between the pulses of light that transport data
Optical fibers carry data in the form of pulses of light over distances of thousands of miles at amazing speeds. They are one of the glories of modern telecommunications technology.
However, their capacity is limited, because the pulses of light need to be lined up one after the other in ...
NASA's Hurricane and Severe Storms Sentinel airborne mission known as HS3 wrapped up for the 2013 Atlantic Ocean hurricane season at the end of September, and had several highlights. HS3 will return to NASA’s Wallops Flight Facility in Wallops Island, Va., for the 2014 Atlantic hurricane season.
During the 2013 mission, two unmanned Global Hawks flew from Wallops for the first time. The mission highlights included studying the Saharan Air Layer, following the genesis of a tropical storm, finding a unique hybrid core or center circulation in a redeveloped storm, obtaining measurements on the strongest side of ...
05.12.2013 | Health and Medicine
05.12.2013 | Ecology, The Environment and Conservation
05.12.2013 | Information Technology
05.12.2013 | Event News
04.12.2013 | Event News
12.11.2013 | Event News