University of Alberta researchers discovered that a zebrafish's stem cells can selectively regenerate damaged photoreceptor cells.
Lead U of A researcher Ted Allison says that for some time geneticists have known that unlike humans, stem cells in zebrafish can replace damaged cells involved in many components of eyesight. Rods and cones are the most important photoreceptors. In humans, rods provide us with night vision while cones give us a full colour look at the world during the day-time.
What was not known says Allison was whether stem cells could be instructed to only replace the cones in its retina. This could have important implications for human eyesight.
"This is the first time in an animal research model that stem cells have only repaired damaged cones," said Allison. "For people with damaged eyesight repairing the cones is most important because it would restore day-time colour vision.
The researchers say that to date almost all success in regenerating photoreceptor cells has been limited to rods not cones. Most of these previous experiments were conducted on nocturnal rodents, animals that require good night vision so they have far more rods than cones.
"This shows us that when cones die in a cone-rich retina, it is primarily cones that regenerate," said Allison. "This suggests the tissue environment provides cues to instruct stem cell how to react."
The researchers say this shows some hope for stem cell therapy that could regenerate damaged cones in people, especially in the cone-rich regions of the retina that provide daytime/colour vision.
Allison says the next step for his team is to identify the particular gene in zebrafish gene that activates repair of damaged cones.
The research was led by U of A Biological Sciences researcher Ted Allison. The researcher's website can be found at www.biology.ualberta.ca/Allison_Lab. The research was funded by the Natural Sciences and Engineering Council of Canada (NSERC). The paper was published Jan. 30 in the journal PLOS ONE.
Brian Murphy | EurekAlert!
Nanoparticle Exposure Can Awaken Dormant Viruses in the Lungs
16.01.2017 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Cholera bacteria infect more effectively with a simple twist of shape
13.01.2017 | Princeton University
Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.
As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...
At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).
Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...
Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.
The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...
UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration
"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...
Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.
Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...
10.01.2017 | Event News
09.01.2017 | Event News
05.01.2017 | Event News
16.01.2017 | Power and Electrical Engineering
16.01.2017 | Information Technology
16.01.2017 | Power and Electrical Engineering