Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Zebrafish Discovery May Shed Light on Human Kidney Function

21.02.2014
Researchers say the discovery of how sodium ions pass through the gill of a zebrafish may be a clue to understanding a key function in the human kidney.

The findings from a collaboration between Mayo Clinic and the Tokyo Institute of Technology appear in the online issue of the American Journal of Physiology-Regulatory, Integrative and Comparative Physiology.

The researchers discovered a protein responsible for gas exchanges in the fish gill structure. Specifically they studied and characterized the Na+/H+ (sodium/hydrogen) exchanger named NHE3, responsible for controlling sodium and hydrogen ions across the gill. The researchers also directly demonstrated that NHE3 can function as a Na+/NH4+ (sodium/ammonium) exchanger.

“This is significant because the fish tends to mimic the process in humans,” says Michael Romero, Ph.D., a Mayo Clinic physiologist who works in nephrology. “This is the true beauty of comparative physiology-– a lot of the organs function by very similar processes, down to ionic transfer.”

In this case the protein allows the sodium ions to be absorbed from the forming urine while at the same time discarding waste from normally functioning cells, thus keeping the body in balance and serving as an energy saving system. The researchers say the same NHE3 protein performs a similar function in the intestine, pancreas, liver, lungs and reproductive system.

The gill is used in the fish as a transport system: sodium ions are nutrients and ammonium carries away waste. It’s a key process allowing zebrafish to extract sodium ions from fresh water. In humans, NHE3 is involved in the acid-waste control system in the kidney, but there hasn’t been a good analysis of that process in humans. Part of this acid-control process in the human kidney is “ammoniagenesis” which requires the initial part of the kidney tubule (proximal tubule) to export ammonia/ammonium. Physiologically, it has been assumed that NHE3 can perform a Na+/NH4+ exchange, but this has never been experimentally demonstrated.

Ammoniagenesis and increased renal sodium bicarbonate absorption are partly under the control of the renin-angiotensin-aldosterone system (RAAS), which means that this work enhances understanding of human hypertension. Researchers say their results in fish can be a clue or starting point for analyzing the process in people. Researchers say they hope to continue their work in other species and ultimately further describe the process in humans.

The research was funded by both institutions. Co-authors include Yusuke Ito, Akira Kato, Ph.D., and Shighisa Hirose, Ph.D., all of the Tokyo Institute of Technology; and Taku Hirata, Ph.D., of Mayo Clinic. Yusuke Ito was a visiting graduate student at Mayo Clinic. Dr. Akira Kato is a visiting research collaborator with Dr. Romero at Mayo Clinic.

About Mayo Clinic
Recognizing 150 years of serving humanity in 2014, Mayo Clinic is a nonprofit worldwide leader in medical care, research and education for people from all walks of life. For more information, visit 150years.mayoclinic.org, http://www.mayoclinic.org and newsnetwork.mayoclinic.org.
MEDIA CONTACT:
Bob Nellis, Mayo Clinic Public Affairs, 507-284-5005, newsbureau@mayo.edu

Bob Nellis | EurekAlert!
Further information:
http://newsnetwork.mayoclinic.org/discussion/zebrafish-discovery-may-shed-light-on-human-kidney-function

More articles from Life Sciences:

nachricht Tracking the American Woodcock
28.07.2015 | University of Arkansas, Fayetteville

nachricht Possible Path Toward First Anti-MERS Drugs
28.07.2015 | American Crystallographic Association (ACA)

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Superfast fluorescence sets new speed record

Plasmonic device has speed and efficiency to serve optical computers

Researchers have developed an ultrafast light-emitting device that can flip on and off 90 billion times a second and could form the basis of optical computing.

Im Focus: Unlocking the rice immune system

Joint BioEnergy Institute study identifies bacterial protein that is key to protecting rice against bacterial blight

A bacterial signal that when recognized by rice plants enables the plants to resist a devastating blight disease has been identified by a multi-national team...

Im Focus: Smarter window materials can control light and energy

Researchers in the Cockrell School of Engineering at The University of Texas at Austin are one step closer to delivering smart windows with a new level of energy efficiency, engineering materials that allow windows to reveal light without transferring heat and, conversely, to block light while allowing heat transmission, as described in two new research papers.

By allowing indoor occupants to more precisely control the energy and sunlight passing through a window, the new materials could significantly reduce costs for...

Im Focus: Simulations lead to design of near-frictionless material

Argonne scientists used Mira to identify and improve a new mechanism for eliminating friction, which fed into the development of a hybrid material that exhibited superlubricity at the macroscale for the first time. Argonne Leadership Computing Facility (ALCF) researchers helped enable the groundbreaking simulations by overcoming a performance bottleneck that doubled the speed of the team's code.

While reviewing the simulation results of a promising new lubricant material, Argonne researcher Sanket Deshmukh stumbled upon a phenomenon that had never been...

Im Focus: NASA satellite camera provides 'EPIC' view of Earth

A NASA camera on the Deep Space Climate Observatory (DSCOVR) satellite has returned its first view of the entire sunlit side of Earth from one million miles away.

The color images of Earth from NASA's Earth Polychromatic Imaging Camera (EPIC) are generated by combining three separate images to create a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

3rd Euro Bio-inspired - International Conference and Exhibition on Bio-inspired Materials

23.07.2015 | Event News

Clash of Realities – International Conference on the Art, Technology and Theory of Digital Games

10.07.2015 | Event News

World Conference on Regenerative Medicine in Leipzig: Last chance to submit abstracts until 2 July

25.06.2015 | Event News

 
Latest News

Possible Path Toward First Anti-MERS Drugs

28.07.2015 | Life Sciences

Smart Hydrogel Coating Creates “Stick-slip” Control of Capillary Action

28.07.2015 | Materials Sciences

Are Fish Getting High on Cocaine?

28.07.2015 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>