Whether from surgery or battle wounds, ugly scars can affect body and mind. Now a new research report appearing online in the FASEB Journal offers a new strategy to reduce or eliminate scars on the skin.
Specifically, scientists from NYU describe how agents that block receptors for adenosine (a molecule generated from ATP which is used by the body to provide energy to muscles) can be applied topically to healing wounds to reduce scar size, yielding skin that feels more like the original, unscarred skin.
"Scars can be disfiguring and, if extensive enough, can lead to diminished function and quality of life," said Bruce N. Cronstein, M.D., a researcher involved in the work from the Division of Translational Medicine in the Department of Medicine at New York University School of Medicine in New York, NY. "We hope that our findings may lead to new agents that diminish scarring and disfigurement following burns, wounds, or even illnesses that destroy skin and lead to a better quality of life for victims of these traumas."
When the skin or other tissues are wounded, ATP leaks from the damaged cells and is then converted to adenosine which promotes healing. Scars form when adenosine continues to be produced at the wound site after the injury is healed, leading to larger, thicker scars than what may have otherwise been there. To study the possibility of reducing scar sizes, Cronstein and colleagues studied wounds on the backs of mice. After the wound closed, the adenosine A2A receptor antagonist was applied. They found that the adenosine A2A receptor agonist prevented excessive scar tissue in the treated mice.
"The vast majority of scars are hardly noticeable, if they can be seen at all," said Gerald Weissmann, M.D., Editor-in-Chief of the FASEB Journal, "but for some, scars can severely disfigure not only the body, but the mind. Finding ways to prevent scarring after wounds or surgery has the potential to improve the quality of life for those who suffer the slings and arrows of outrageous fortune, now and for generations to come."
Receive monthly highlights from the FASEB Journal by e-mail. Sign up at http://www.faseb.org/fjupdate.aspx. The FASEB Journal is published by the Federation of the American Societies for Experimental Biology (FASEB) and is among the most cited biology journals worldwide according to the Institute for Scientific Information. In 2010, the journal was recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century. FASEB is composed of 26 societies with more than 100,000 members, making it the largest coalition of biomedical research associations in the United States. Celebrating 100 Years of Advancing the Life Sciences in 2012, FASEB is rededicating its efforts to advance health and well-being by promoting progress and education in biological and biomedical sciences through service to our member societies and collaborative advocacy.
Details: Miguel Perez-Aso, Luis Chiriboga, and Bruce N. Cronstein. Pharmacological blockade of adenosine A2A receptors diminishes scarring. FASEB J doi:10.1096/fj.12-209627 ; http://www.fasebj.org/content/early/2012/07/05/fj.12-209627.abstract
Cody Mooneyhan | EurekAlert!
Flow of cerebrospinal fluid regulates neural stem cell division
22.05.2018 | Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt
Chemists at FAU successfully demonstrate imine hydrogenation with inexpensive main group metal
22.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
02.05.2018 | Event News
13.04.2018 | Event News
12.04.2018 | Event News
18.05.2018 | Power and Electrical Engineering
18.05.2018 | Information Technology
18.05.2018 | Information Technology