Recycling or “scrap press”: physicians at the Ruhr-Universität have found out which molecular mechanisms decide about the fate of the import receptor Pex18. Pex18 is responsible for the import of proteins into specific cell components, namely peroxisomes. Two opposing regulatory circuits determine whether the receptor remains active or is broken down after the transport has been completed.
Peroxisomal protein transport model: The import receptor for peroxisomal PTS2 proteins is the two-part receptor complex Pex18/Pex7. After the PTS2 protein has been released into the interior of the peroxisome, the receptor is exported. Docking an ubiquitin (Ub) with Pex18 sends out the signal that the receptor can be recycled for new import reactions. The docking of the individual ubiquitins is determined by the E1 enzyme, the E2 enzyme Pex4p as well as the E3 enzymes Pex12/Pex10. If an ubiquitin chain forms at Pex18, the proteasome breaks down Pex18. Docking of the ubiquitin chain is effected through the E1 enzyme, the E2 enzyme Ubc4 as well as the E3 enzymes Pex2/Pex10.
© RUB, Grafik: Platta
Dr. Harald W. Platta | EurekAlert!
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