Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

WSU researchers find way to make cancer cells more mortal

19.07.2010
Washington State University researchers have discovered a way to help cancer cells age and die, creating a promising avenue for slowing and even stopping the growth of tumors.

"Hopefully, we can make cancer cells die like normal cells," says Weihang Chai, an assistant professor in the WSU School of Molecular Biosciences and WWAMI medical education program in Spokane. "Basically, you make the cancer cell go from immortal to mortal."

Normal cells lose a little bit of their DNA every time they reproduce as the molecule's strands lose part of their protective tips, called telomeres. Eventually, the telomeres become too short, signaling to the cell to stop replicating and growing.

But cancer cells have a mechanism to keep their DNA strands from shortening, giving them a near eternal life. This is because the enzyme telomerase extends one strand of the cancer cell's DNA while other proteins help extend the second strand.

Chai and her colleagues, writing in the current issue of The EMBO Journal, say they have found a regulatory protein that controls the production of that second strand. They have also found a protein required to synthesize it.

If that second strand of DNA cannot be lengthened, says Chai, it behaves like a normal cell and dies a normal death. She says her team will now focus on developing a strategy to block the regulatory protein's function.

Chai's work is funded by the National Institutes of Health, the American Cancer Society and Washington State.

Robert Strenge | EurekAlert!
Further information:
http://www.wsu.edu

More articles from Life Sciences:

nachricht Navigational view of the brain thanks to powerful X-rays
18.10.2017 | Georgia Institute of Technology

nachricht Separating methane and CO2 will become more efficient
18.10.2017 | KU Leuven

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Neutron star merger directly observed for the first time

University of Maryland researchers contribute to historic detection of gravitational waves and light created by event

On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...

Im Focus: Breaking: the first light from two neutron stars merging

Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.

Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ASEAN Member States discuss the future role of renewable energy

17.10.2017 | Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

 
Latest News

Osaka university researchers make the slipperiest surfaces adhesive

18.10.2017 | Materials Sciences

Space radiation won't stop NASA's human exploration

18.10.2017 | Physics and Astronomy

Los Alamos researchers and supercomputers help interpret the latest LIGO findings

18.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>