Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Wrong-time eating reduces fertility in fruit flies

08.06.2011
Penn study points to fertility-metabolism connection

Dieticians will tell you it isn't healthy to eat late at night: it's a recipe for weight gain. In fruit flies, at least, there's another consequence: reduced fertility.

That's the conclusion of a new study this week in Cell Metabolism by researchers at the Perelman School of Medicine at the University of Pennsylvania, in which they manipulated circadian rhythms in fruit flies and measured the affect on egg-laying capacity.

Lead author Amita Sehgal, PhD, John Herr Musser Professor of Neuroscience, stresses, though, that what is true in flies grown in a lab does not necessarily hold for humans, and any potential link between diet and reproduction would have to be independently tested.

"I wouldn't say eating at the wrong time of the day makes people less fertile, though that is the implication," says Sehgal, who is also a Howard Hughes Medical Institute Investigator. "I would say that eating at the wrong time of the day has deleterious consequences for physiology."

It's All Connected

Many aspects of animal biology cycle over the course of a day. Sleep and wakefulness, activity and rest, body temperature, and more, all fluctuate in a pattern called a circadian rhythm. Disruption of these rhythms has been shown to negatively affect physiology. Shift workers, for instance, often suffer from psychological and metabolic issues that colleagues on normal hours do not. Rodents with disrupted circadian rhythms are more likely to develop obesity.

For a while, Sehgal explains, researchers believed animals had a single master molecular clock, located in the brain, that controlled activity throughout the body. In recent years, however, they have come to understand that some individual organs also have their own, independent clocks, like townspeople who wear a wristwatch and keep it synchronized with the clock in city hall.

The mammalian liver is one organ that has its own independent clock. In 2008, Sehgal's team discovered that the fruit fly equivalent of the liver, called the fat body, has its own clock, which controls eating and food storage. They wanted to know what would happen if the fat body clock became desynchronized from the master clock in the brain.

Decoupling Clocks

First, her team asked which fly genes are controlled specifically by the fat body clock. Using gene chip microarrays, they identified 81 genes related to lipid and carbohydrate metabolism, the immune system, and reproduction that fit those criteria.

Next, the researchers attempted to decouple the fat body and central clocks by keeping the flies in constant darkness (to eliminate effects of light on these clocks) and feeding them at times when they don't normally eat. They found the two clocks could be desynchronized: disrupting the animals' feeding cycles altered the cycling of genes controlled by the fat-body clock, but not those regulated by the central clock itself itself.

Finally, the team addressed the functional consequences of this desynchronization, by counting the number of eggs the flies laid under different conditions. Flies fed at the "right" time of the day deposited about 8 eggs per day, compared to about 5 when they fed at the "wrong" time.

"Circadian desynchrony caused by feeding at the 'wrong' time of day leads to a defect in overall reproductive capacity," the authors wrote.

The next question to pursue, Sehgal says, is finding the molecular mechanism that controls this phenomenon: How does the fat body communicate with the ovaries. And, more importantly, is this effect restricted to fruit flies, or does it also occur in higher organisms, including humans.

The research was funded by the Howard Hughes Medical Institute and the National Institute of Neurological Disorders and Stroke and the National Heart, Lung, and Blood Institute.

Other authors include Penn postdoctoral fellows Kanyan Xu, Justin R. DiAngelo, and Michael E. Hughes, as well as John B. Hogenesch, associate professor of Pharmacology.

Penn Medicine is one of the world's leading academic medical centers, dedicated to the related missions of medical education, biomedical research, and excellence in patient care. Penn Medicine consists of the Raymond and Ruth Perelman School of Medicine at the University of Pennsylvania (founded in 1765 as the nation's first medical school) and the University of Pennsylvania Health System, which together form a $4 billion enterprise.

Penn's Perelman School of Medicine is currently ranked #2 in U.S. News & World Report's survey of research-oriented medical schools and among the top 10 schools for primary care. The School is consistently among the nation's top recipients of funding from the National Institutes of Health, with $507.6 million awarded in the 2010 fiscal year.

The University of Pennsylvania Health System's patient care facilities include: The Hospital of the University of Pennsylvania -- recognized as one of the nation's top 10 hospitals by U.S. News & World Report; Penn Presbyterian Medical Center; and Pennsylvania Hospital – the nation's first hospital, founded in 1751. Penn Medicine also includes additional patient care facilities and services throughout the Philadelphia region.

Penn Medicine is committed to improving lives and health through a variety of community-based programs and activities. In fiscal year 2010, Penn Medicine provided $788 million to benefit our community.

Karen Kreeger | EurekAlert!
Further information:
http://www.uphs.upenn.edu

More articles from Life Sciences:

nachricht Newly discovered bacteria-binding protein in the intestine
08.12.2016 | University of Gothenburg

nachricht The balancing act: An enzyme that links endocytosis to membrane recycling
07.12.2016 | National Centre for Biological Sciences

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

Decoding cement's shape promises greener concrete

08.12.2016 | Materials Sciences

Will Earth still exist 5 billion years from now?

08.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>