Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Where cancer cells hide from the immune system

27.03.2014

FAU researchers have discovered that tumour cells can hide from antibody therapy in bone marrow

Scientists from the Division of Genetics at Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) in collaboration with Universitätsklinikum Erlangen have made a breakthrough discovery in cancer research.

For the first time, scientists have been able to simulate the complexity of the human immune system and investigate where cancer cells hide when attacked by the immune system. This research is especially relevant for destroying cancer cells through antibody therapy and shows ways that cancer treatment can be improved today. The researchers recently published their findings in the renowned journal Cell Reports.*

Antibodies that are manufactured specifically to fight cancer cells are an essential part of treating breast cancer and lymphoma. They can detect and mark cancer cells in the body so that the malfunctioning cells can be destroyed by the immune system.

... more about:
»FAU »Genetics »MIT »chemotherapy »effects »immune »therapy »tumour

However, some cells may survive attacks by the immune system. In the worst case, this can cause tumours to return. 'A key question in cancer therapy is to find out where tumour cells can hide from the immune system,' states Prof. Dr. Falk Nimmerjahn from the Division of Genetics at FAU. 'If we know the answer to this, we can improve current drugs to target where the malformed cells are hiding'.

Two research teams, one from FAU and the other from the Massachusetts Institute of Technology (MIT, Cambridge) (Pallasch et al. Cell), have independently made important breakthroughs in this area. Both research teams were able to show that the effects of antibodies used in human cancer therapy are weakened if tumour cells are found in bone marrow.

'This gives us a unique opportunity to find out how we can improve the antibodies currently used in cancer treatment to remove all tumour cells so that there is actually a chance of curing patients,' says Dr. Anja Lux, research team leader, Division of Genetics, FAU. The significance of these findings is demonstrated by the ability of both research teams to simulate the complexity of the human immune system in their experiments which indicates that the results can be applied to humans with a greater probability.

Further preliminary investigations at MIT lead researchers to believe that a combination of chemotherapy and antibody therapy can lead to greater success in destroying cancer cells in bone marrow. This is an interesting preliminary result which the researchers in Erlangen are intending to take a step further.

'Now that we know where the cancer cells are hiding, we can improve antibody therapy to better activate immune cells in the bone marrow,' explains Prof. Nimmerjahn. This will help to avoid the harmful side effects of chemotherapy, reduce risk for patients and increase chances of curing patients.

References:
*Lux et al., Cell Reports 7, 1-13, 2014; doi:
Pallasch et al., Cell 156, 590-602, 2014

Contact for media:
Prof. Dr. Falk Nimmerjahn
falk.nimmerjahn@fau.de

Blandina Mangelkramer | idw - Informationsdienst Wissenschaft
Further information:
http://www.fau.de/

Further reports about: FAU Genetics MIT chemotherapy effects immune therapy tumour

More articles from Life Sciences:

nachricht Protein Shake-Up
27.03.2015 | Oak Ridge National Laboratory

nachricht How did the chicken cross the sea?
27.03.2015 | Michigan State University

All articles from Life Sciences >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Experiment Provides the Best Look Yet at 'Warm Dense Matter' at Cores of Giant Planets

In an experiment at the Department of Energy's SLAC National Accelerator Laboratory, scientists precisely measured the temperature and structure of aluminum as...

Im Focus: Energy-autonomous and wireless monitoring protects marine gearboxes

The IPH presents a solution at HANNOVER MESSE 2015 to make ship traffic more reliable while decreasing the maintenance costs at the same time. In cooperation with project partners, the research institute from Hannover, Germany, has developed a sensor system which continuously monitors the condition of the marine gearbox, thus preventing breakdowns. Special feature: the monitoring system works wirelessly and energy-autonomously. The required electrical power is generated where it is needed – directly at the sensor.

As well as cars need to be certified regularly (in Germany by the TÜV – Technical Inspection Association), ships need to be inspected – if the powertrain stops...

Im Focus: 3-D satellite, GPS earthquake maps isolate impacts in real time

Method produced by UI researcher could improve reaction time to deadly, expensive quakes

When an earthquake hits, the faster first responders can get to an impacted area, the more likely infrastructure--and lives--can be saved.

Im Focus: Atlantic Ocean overturning found to slow down already today

The Atlantic overturning is one of Earth’s most important heat transport systems, pumping warm water northwards and cold water southwards. Also known as the Gulf Stream system, it is responsible for the mild climate in northwestern Europe. 

Scientists now found evidence for a slowdown of the overturning – multiple lines of observation suggest that in recent decades, the current system has been...

Im Focus: Robot inspects concrete garage floors and bridge roadways for damage

Because they are regularly subjected to heavy vehicle traffic, emissions, moisture and salt, above- and underground parking garages, as well as bridges, frequently experience large areas of corrosion. Most inspection systems to date have only been capable of inspecting smaller surface areas.

From April 13 to April 17 at the Hannover Messe (hall 2, exhibit booth C16), engineers from the Fraunhofer Institute for Nondestructive Testing IZFP will be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Conference On Regenerative Medicine 2015: Registration And Abstract Submission Now Open

25.03.2015 | Event News

University presidents from all over the world meet in Hamburg

19.03.2015 | Event News

10. CeBiTec Symposium zum Big Data-Problem

17.03.2015 | Event News

 
Latest News

Two Most Destructive Termite Species Forming Superswarms in South Florida

27.03.2015 | Agricultural and Forestry Science

ORNL-Led Team Demonstrates Desalination with Nanoporous Graphene Membrane

27.03.2015 | Materials Sciences

Coorong Fish Hedge Their Bets for Survival

27.03.2015 | Ecology, The Environment and Conservation

VideoLinks
B2B-VideoLinks
More VideoLinks >>>